DegronMD

Uniprot ID: Q9NRU3

Source protein: Metal transporter CNNM1

Source gene: CNNM1

Class: DEG_SCF_FBW7_1

Location: 946:951

E3 ligase: FBXW7

DEGRON score: 0.5787

ASA_SCORE: 82.95

COIL: 0.7937

CONS_SCORE: 0.2798

DSS_SCORE: 0.9168

HELIX: 0.0197

FCONS_SCORE: 0.9772

RIG_SCORE: 0.7421

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P948H	TCGA-A5-A1OF	UCEC	TCGA	LTPLIT	DEG_SCF_FBW7_1	0.7694
p.P948H	TCGA-E6-A1LX	UCEC	TCGA	LTPLIT	DEG_SCF_FBW7_1	0.7694
p.P948H	TCGA-ER-A19N	SKCM	TCGA	LTPLIT	DEG_SCF_FBW7_1	0.7694
p.P948S	TCGA-IB-7651	PAAD	TCGA	LTPLIT	DEG_SCF_FBW7_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NRU3	Metal transporter CNNM1	DEG_SCF_FBW7_1	946:951	LTPLIT	FBXW7	0.5787	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons