DegronMD

Uniprot ID: P78527

Source protein: DNA-dependent protein kinase catalytic subunit

Source gene: PRKDC

Class: DEG_SCF_FBW7_2

Location: 3197:3202

E3 ligase: FBXW7

DEGRON score: 0.7342

ASA_SCORE: 68.6

COIL: 0.8522

CONS_SCORE: 0.2715

DSS_SCORE: 0.513

HELIX: 0.1088

FCONS_SCORE: 0.7365

RIG_SCORE: 0.7123

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E3194K	TCGA-95-7948	LUAD	TCGA	LTPLPE	DEG_SCF_FBW7_2	0.25
p.E3194K	DO25133	LUAD	ICGC	LTPLPE	DEG_SCF_FBW7_2	0.25
p.E3194D	TCGA-AP-A059	UCEC	TCGA	LTPLPE	DEG_SCF_FBW7_2	0.25
p.E3194D	TCGA-BA-5152	HNSC	TCGA	LTPLPE	DEG_SCF_FBW7_2	0.25
p.E3194D	DO14393	HNSC	ICGC	LTPLPE	DEG_SCF_FBW7_2	0.25
p.E3194D	DO41361	UCEC	ICGC	LTPLPE	DEG_SCF_FBW7_2	0.25
p.E3193Q	TCGA-D1-A17K	UCEC	TCGA	LTPLPE	DEG_SCF_FBW7_2	0.2222
p.E3193Q	DO42937	UCEC	ICGC	LTPLPE	DEG_SCF_FBW7_2	0.2222
p.L3196R	TCGA-QS-A5YQ	UCEC	TCGA	LTPLPE	DEG_SCF_FBW7_2	0.75
p.L3196R	DO49073	UCEC	ICGC	LTPLPE	DEG_SCF_FBW7_2	0.75
p.L3199V	DO472	BLCA	ICGC	LTPLPE	DEG_SCF_FBW7_2	0.6765
p.L3199F	DO218404	BRCA	ICGC	LTPLPE	DEG_SCF_FBW7_2	0.6981
p.S3190N	DO233732	GACA	ICGC	LTPLPE	DEG_SCF_FBW7_2	0.1389
p.T3197S	DO228941	LICA	ICGC	LTPLPE	DEG_SCF_FBW7_2	0.7116
p.E3193K	DO50753	LICA	ICGC	LTPLPE	DEG_SCF_FBW7_2	0.2222
p.M3205V	DO45127	LIRI	ICGC	LTPLPE	DEG_SCF_FBW7_2	0.6944
p.M3205R	DO220863	MELA	ICGC	LTPLPE	DEG_SCF_FBW7_2	0.6944
p.T3198S	SIDM01004	Chronic Myelogenous Leukemia	GDSC	LTPLPE	DEG_SCF_FBW7_2	0.8227
p.T3198S	SIDM00557	Neuroblastoma	GDSC	LTPLPE	DEG_SCF_FBW7_2	0.8227
p.T3198S	SIDM00615	Hepatocellular Carcinoma	GDSC	LTPLPE	DEG_SCF_FBW7_2	0.8227
p.T3198S	SIDM00234	Other Solid Cancers	GDSC	LTPLPE	DEG_SCF_FBW7_2	0.8227
p.T3198S	SIDM01197	Colorectal Carcinoma	GDSC	LTPLPE	DEG_SCF_FBW7_2	0.8227
p.T3198S	SIDM01005	Acute Myeloid Leukemia	GDSC	LTPLPE	DEG_SCF_FBW7_2	0.8227
p.T3198S	SIDM00569	Osteosarcoma	GDSC	LTPLPE	DEG_SCF_FBW7_2	0.8227
p.T3198S	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	LTPLPE	DEG_SCF_FBW7_2	0.8227
p.T3198S	SIDM00466	Ovarian Carcinoma	GDSC	LTPLPE	DEG_SCF_FBW7_2	0.8227
p.T3198S	SIDM00351	Oral Cavity Carcinoma	GDSC	LTPLPE	DEG_SCF_FBW7_2	0.8227
p.T3198S	SIDM00383	Gastric Carcinoma	GDSC	LTPLPE	DEG_SCF_FBW7_2	0.8227
p.T3198S	SIDM00294	Small Cell Lung Carcinoma	GDSC	LTPLPE	DEG_SCF_FBW7_2	0.8227
p.T3198S	SIDM00214	Colorectal Carcinoma	GDSC	LTPLPE	DEG_SCF_FBW7_2	0.8227
p.T3198S	SIDM00997	Thyroid Gland Carcinoma	GDSC	LTPLPE	DEG_SCF_FBW7_2	0.8227
p.T3198S	SIDM00580	Acute Myeloid Leukemia	GDSC	LTPLPE	DEG_SCF_FBW7_2	0.8227
p.T3198S	SIDM00397	Acute Myeloid Leukemia	GDSC	LTPLPE	DEG_SCF_FBW7_2	0.8227
p.T3198S	SIDM00655	Other Solid Cancers	GDSC	LTPLPE	DEG_SCF_FBW7_2	0.8227
p.T3198S	SIDM01217	Other Blood Cancers	GDSC	LTPLPE	DEG_SCF_FBW7_2	0.8227
p.T3198S	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	LTPLPE	DEG_SCF_FBW7_2	0.8227
p.T3198S	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	LTPLPE	DEG_SCF_FBW7_2	0.8227
p.T3198S	SIDM00996	Thyroid Gland Carcinoma	GDSC	LTPLPE	DEG_SCF_FBW7_2	0.8227
p.T3198S	SIDM00604	Oral Cavity Carcinoma	GDSC	LTPLPE	DEG_SCF_FBW7_2	0.8227
p.T3198S	SIDM01551	Gastric Carcinoma	GDSC	LTPLPE	DEG_SCF_FBW7_2	0.8227
p.T3198S	SIDM01622	Breast Carcinoma	GDSC	LTPLPE	DEG_SCF_FBW7_2	0.8227
p.T3198S	SIDM01391	Neuroblastoma	GDSC	LTPLPE	DEG_SCF_FBW7_2	0.8227

Drug responses associated with PRKDC mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM01030	ESCA\|oesophagus	p.L2692W (No)	GDSC	Voxtalisib	101.5919
SIDM01030	ESCA\|oesophagus	p.L2692W (No)	GDSC	NU7441	9.9122
SIDM00926	UNCLASSIFIED\|lung_NSCLC_not_specified	p.Q2300E (No)	GDSC	Voxtalisib	366.5599
SIDM00926	UNCLASSIFIED\|lung_NSCLC_not_specified	p.Q2300E (No)	GDSC	NU7441	17.9046
SIDM00554	UNCLASSIFIED\|ovary	p.D1575Y (No)	GDSC	Voxtalisib	104.428
SIDM00554	UNCLASSIFIED\|ovary	p.D1575Y (No)	GDSC	NU7441	10.6448
SIDM00720	MESO\|mesothelioma	p.I1413V (No)	GDSC	Voxtalisib	316.6117
SIDM00720	MESO\|mesothelioma	p.I1413V (No)	GDSC	NU7441	8.6079
SIDM00223	SCLC\|lung_small_cell_carcinoma	p.D1808G (No)	GDSC	Voxtalisib	50.7589
SIDM00223	SCLC\|lung_small_cell_carcinoma	p.D1808G (No)	GDSC	NU7441	6.1589
SIDM00130	PAAD\|pancreas	p.F649L (No)	GDSC	Voxtalisib	206.9135
SIDM00240	CESC\|cervix	p.R3268K (No)	GDSC	Voxtalisib	22.5683
SIDM00240	CESC\|cervix	p.R3268K (No)	GDSC	NU7441	16.1205
SIDM00578	NB\|neuroblastoma	p.R2752Q (No)	GDSC	Voxtalisib	13.7088
SIDM00578	NB\|neuroblastoma	p.R2752Q (No)	GDSC	NU7441	8.8847
SIDM00841	COREAD\|large_intestine	p.A1301G (No)	GDSC	Voxtalisib	170.9864
SIDM00841	COREAD\|large_intestine	p.A1301G (No)	GDSC	NU7441	27.5016
SIDM00190	SKCM\|melanoma	p.S2809N (No)	GDSC	Voxtalisib	84.7699
SIDM00190	SKCM\|melanoma	p.S2809N (No)	GDSC	NU7441	22.0149
SIDM00190	SKCM\|melanoma	p.G500S (No)	GDSC	Voxtalisib	84.7699
SIDM00190	SKCM\|melanoma	p.G500S (No)	GDSC	NU7441	22.0149
SIDM00931	THCA\|thyroid	p.G1598S (No)	GDSC	Voxtalisib	88.8189
SIDM00931	THCA\|thyroid	p.G1598S (No)	GDSC	NU7441	10.3605
SIDM00327	UNCLASSIFIED\|Hodgkin_lymphoma	p.L2401F (No)	GDSC	Voxtalisib	138.7875
SIDM00327	UNCLASSIFIED\|Hodgkin_lymphoma	p.L2401F (No)	GDSC	NU7441	12.9659
SIDM00941	KIRC\|kidney	p.T1539M (No)	GDSC	Voxtalisib	114.8877
SIDM00941	KIRC\|kidney	p.T1539M (No)	GDSC	NU7441	5.5622
SIDM01037	BRCA\|breast	p.K2499Q (No)	GDSC	NU7441	10.9466
SIDM01037	BRCA\|breast	p.K2499Q (No)	GDSC	NU7441	25.466
SIDM01029	ESCA\|oesophagus	p.K1359* (No)	GDSC	Voxtalisib	72.5951
SIDM01029	ESCA\|oesophagus	p.K1359* (No)	GDSC	NU7441	12.9657
SIDM00826	COREAD\|large_intestine	p.P3200S (Yes)	GDSC	Voxtalisib	137.4487
SIDM00826	COREAD\|large_intestine	p.P3200S (Yes)	GDSC	NU7441	18.9016
SIDM00315	GBM\|glioma	p.A895V (No)	GDSC	Voxtalisib	173.5417
SIDM00315	GBM\|glioma	p.A895V (No)	GDSC	NU7441	10.3773
SIDM00680	COREAD\|large_intestine	p.V291M (No)	GDSC	Voxtalisib	212.4715
SIDM00680	COREAD\|large_intestine	p.V291M (No)	GDSC	NU7441	5.1554
SIDM01045	UCEC\|endometrium	p.G2112delG (No)	GDSC	Voxtalisib	85.432
SIDM01045	UCEC\|endometrium	p.G2112delG (No)	GDSC	NU7441	73.183
SIDM00449	UNCLASSIFIED\|B_cell_leukemia	p.K3171T (No)	GDSC	Voxtalisib	10.4705
SIDM00449	UNCLASSIFIED\|B_cell_leukemia	p.K3171T (No)	GDSC	NU7441	1.7084
SIDM00449	UNCLASSIFIED\|B_cell_leukemia	p.R1821H (No)	GDSC	Voxtalisib	10.4705
SIDM00449	UNCLASSIFIED\|B_cell_leukemia	p.R1821H (No)	GDSC	NU7441	1.7084
SIDM00151	OV\|ovary	p.C1454Y (No)	GDSC	NU7441	5.7143
SIDM00145	ALL\|lymphoblastic_leukemia	p.R2728C (No)	GDSC	Voxtalisib	29.7542
SIDM00145	ALL\|lymphoblastic_leukemia	p.R2728C (No)	GDSC	NU7441	3.8267
SIDM00145	ALL\|lymphoblastic_leukemia	p.G1788C (No)	GDSC	Voxtalisib	29.7542
SIDM00145	ALL\|lymphoblastic_leukemia	p.G1788C (No)	GDSC	NU7441	3.8267
SIDM00121	ALL\|lymphoblastic_leukemia	p.G1512R (No)	GDSC	Voxtalisib	61.207
SIDM00121	ALL\|lymphoblastic_leukemia	p.G1512R (No)	GDSC	NU7441	4.7772
SIDM00121	ALL\|lymphoblastic_leukemia	p.S1511C (No)	GDSC	Voxtalisib	61.207
SIDM00121	ALL\|lymphoblastic_leukemia	p.S1511C (No)	GDSC	NU7441	4.7772
SIDM00494	LUAD\|lung_NSCLC_adenocarcinoma	p.T2152A (No)	GDSC	Voxtalisib	68.7291
SIDM00494	LUAD\|lung_NSCLC_adenocarcinoma	p.T2152A (No)	GDSC	NU7441	39.3921
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.R1734W (No)	GDSC	Voxtalisib	10.9668
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.R1734W (No)	GDSC	NU7441	7.3347
SIDM00661	DLBC\|B_cell_lymphoma	p.Y4038C (No)	GDSC	Voxtalisib	58.3139
SIDM00661	DLBC\|B_cell_lymphoma	p.Y4038C (No)	GDSC	NU7441	5.8392
SIDM00661	DLBC\|B_cell_lymphoma	p.Y3714C (No)	GDSC	Voxtalisib	58.3139
SIDM00661	DLBC\|B_cell_lymphoma	p.Y3714C (No)	GDSC	NU7441	5.8392
SIDM00081	SKCM\|melanoma	p.G3935S (No)	GDSC	Voxtalisib	20.729
SIDM00081	SKCM\|melanoma	p.G3935S (No)	GDSC	NU7441	4.1629
SIDM00208	LGG\|glioma	p.F3418I (No)	GDSC	Voxtalisib	150.0196
SIDM00208	LGG\|glioma	p.F3418I (No)	GDSC	NU7441	22.241
SIDM00108	SKCM\|melanoma	p.P2707S (No)	GDSC	Voxtalisib	133.9456
SIDM00901	UCEC\|endometrium	p.R3334M (No)	GDSC	Voxtalisib	21.5643
SIDM00901	UCEC\|endometrium	p.R3334M (No)	GDSC	NU7441	2.5771
SIDM00901	UCEC\|endometrium	p.R1136H (No)	GDSC	Voxtalisib	21.5643
SIDM00901	UCEC\|endometrium	p.R1136H (No)	GDSC	NU7441	2.5771
SIDM00214	COREAD\|large_intestine	p.S60fs*27 (No)	GDSC	Voxtalisib	67.3632
SIDM00214	COREAD\|large_intestine	p.S60fs*27 (No)	GDSC	NU7441	8.8588
SIDM00785	LAML\|acute_myeloid_leukaemia	p.F446L (No)	GDSC	Voxtalisib	114.4239
SIDM00785	LAML\|acute_myeloid_leukaemia	p.F446L (No)	GDSC	NU7441	4.3828
SIDM01034	UNCLASSIFIED\|B_cell_leukemia	p.R2726* (No)	GDSC	Voxtalisib	24.2435
SIDM01034	UNCLASSIFIED\|B_cell_leukemia	p.R2726* (No)	GDSC	NU7441	4.532
SIDM00045	STAD\|stomach	p.T3598S (No)	GDSC	Voxtalisib	16.1917
SIDM00045	STAD\|stomach	p.T3598S (No)	GDSC	NU7441	5.6683
SIDM00045	STAD\|stomach	p.P1733L (No)	GDSC	Voxtalisib	16.1917
SIDM00045	STAD\|stomach	p.P1733L (No)	GDSC	NU7441	5.6683
SIDM00250	ESCA\|oesophagus	p.K832E (No)	GDSC	Voxtalisib	85.1029
SIDM00250	ESCA\|oesophagus	p.K832E (No)	GDSC	NU7441	3.9196
SIDM01007	ALL\|lymphoblastic_leukemia	p.P3200S (Yes)	GDSC	Voxtalisib	41.4556
SIDM01007	ALL\|lymphoblastic_leukemia	p.P3200S (Yes)	GDSC	NU7441	1.5512
SIDM00781	COREAD\|large_intestine	p.R2597* (No)	GDSC	Voxtalisib	169.812
SIDM00781	COREAD\|large_intestine	p.R2597* (No)	GDSC	NU7441	27.4364
SIDM00974	SKCM\|melanoma	p.A378E (No)	GDSC	Voxtalisib	23.1191
SIDM00974	SKCM\|melanoma	p.A378E (No)	GDSC	NU7441	2.4664
SIDM00537	COREAD\|large_intestine	p.M96fs*11 (No)	GDSC	Voxtalisib	46.0663
SIDM00537	COREAD\|large_intestine	p.M96fs*11 (No)	GDSC	NU7441	14.8175
SIDM00235	KIRC\|kidney	p.Q1583R (No)	GDSC	Voxtalisib	180.5768
SIDM00235	KIRC\|kidney	p.Q1583R (No)	GDSC	NU7441	26.7072
SIDM01229	NB\|neuroblastoma	p.L2401I (No)	GDSC	Voxtalisib	39.8005
SIDM01229	NB\|neuroblastoma	p.L2401I (No)	GDSC	NU7441	11.2949
SIDM00381	CESC\|cervix	p.R3884W (No)	GDSC	Voxtalisib	537.3217
SIDM00381	CESC\|cervix	p.R3884W (No)	GDSC	NU7441	25.5961
SIDM00755	LUAD\|lung_NSCLC_adenocarcinoma	p.A1646T (No)	GDSC	Voxtalisib	89.44
SIDM00755	LUAD\|lung_NSCLC_adenocarcinoma	p.A1646T (No)	GDSC	NU7441	3.0324
SIDM00980	STAD\|stomach	p.L3899V (No)	GDSC	Voxtalisib	30.6098
SIDM00980	STAD\|stomach	p.L3899V (No)	GDSC	NU7441	8.0945
SIDM00565	HNSC\|head_and_neck	p.L3150V (No)	GDSC	Voxtalisib	59.0274
SIDM00565	HNSC\|head_and_neck	p.L3150V (No)	GDSC	NU7441	10.9074
SIDM01009	NB\|neuroblastoma	p.V1451L (No)	GDSC	Voxtalisib	20.9703
SIDM01009	NB\|neuroblastoma	p.V1451L (No)	GDSC	NU7441	3.0965
SIDM00100	MESO\|mesothelioma	p.L2336P (No)	GDSC	Voxtalisib	383.8589
SIDM00100	MESO\|mesothelioma	p.L2336P (No)	GDSC	NU7441	50.0438
SIDM00206	GBM\|glioma	p.R3900L (No)	GDSC	Voxtalisib	87.7285
SIDM00206	GBM\|glioma	p.R3900L (No)	GDSC	NU7441	6.1208
SIDM00214	COREAD\|large_intestine	p.V3936M (No)	GDSC	Voxtalisib	67.3632
SIDM00214	COREAD\|large_intestine	p.V3936M (No)	GDSC	NU7441	8.8588
SIDM00244	NB\|neuroblastoma	p.L3253R (No)	GDSC	Voxtalisib	12.8608
SIDM00244	NB\|neuroblastoma	p.L3253R (No)	GDSC	NU7441	3.0887
SIDM01088	UNCLASSIFIED\|endometrium	p.R1815C (No)	GDSC	Voxtalisib	6.3174
SIDM01088	UNCLASSIFIED\|endometrium	p.R1815C (No)	GDSC	NU7441	21.5196
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.R2403H (No)	GDSC	NU7441	5.3993
SIDM00718	LUAD\|lung_NSCLC_adenocarcinoma	p.D2072V (No)	GDSC	Voxtalisib	123.1723
SIDM00718	LUAD\|lung_NSCLC_adenocarcinoma	p.D2072V (No)	GDSC	NU7441	32.3155
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.E3638fs*14 (No)	GDSC	NU7441	5.3993
SIDM00220	OV\|ovary	p.L143P (No)	GDSC	Voxtalisib	163.5666
SIDM00220	OV\|ovary	p.L143P (No)	GDSC	NU7441	6.6559
SIDM00690	HNSC\|head_and_neck	p.D1747G (No)	GDSC	NU7441	29.1464
SIDM00415	UNCLASSIFIED\|B_cell_leukemia	p.R3424L (No)	GDSC	Voxtalisib	50.2447
SIDM00415	UNCLASSIFIED\|B_cell_leukemia	p.R3424L (No)	GDSC	NU7441	54.1206
SIDM01099	NB\|neuroblastoma	p.H1458Y (No)	GDSC	Voxtalisib	40.0538
SIDM01099	NB\|neuroblastoma	p.H1458Y (No)	GDSC	NU7441	10.0424
SIDM01090	COREAD\|large_intestine	p.L2891R (No)	GDSC	Voxtalisib	62.6047
SIDM01090	COREAD\|large_intestine	p.L2891R (No)	GDSC	NU7441	9.3592
SIDM01106	SKCM\|melanoma	p.P3200S (Yes)	GDSC	Voxtalisib	100.0847
SIDM01106	SKCM\|melanoma	p.P3200S (Yes)	GDSC	NU7441	16.6316
SIDM01106	SKCM\|melanoma	p.Q3132H (No)	GDSC	Voxtalisib	100.0847
SIDM01106	SKCM\|melanoma	p.Q3132H (No)	GDSC	NU7441	16.6316
SIDM00633	BRCA\|breast	p.T3634S (No)	GDSC	Voxtalisib	93.3149
SIDM00633	BRCA\|breast	p.T3634S (No)	GDSC	NU7441	38.7132
SIDM00633	BRCA\|breast	p.T3634S (No)	GDSC	NU7441	377.35
SIDM00516	SKCM\|melanoma	p.A1679V (No)	GDSC	Voxtalisib	32.0755
SIDM00516	SKCM\|melanoma	p.A1679V (No)	GDSC	NU7441	9.4607
SIDM00354	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.E1714Q (No)	GDSC	Voxtalisib	402.5801
SIDM00354	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.E1714Q (No)	GDSC	NU7441	5.2361
SIDM00184	SKCM\|melanoma	p.M333I (No)	GDSC	Voxtalisib	72.8191
SIDM00184	SKCM\|melanoma	p.M333I (No)	GDSC	NU7441	34.401
SIDM00945	COREAD\|large_intestine	p.G1512R (No)	GDSC	NU7441	38.777
SIDM00459	DLBC\|B_cell_lymphoma	p.Y788C (No)	GDSC	NU7441	1.2279
SIDM00629	BRCA\|breast	p.D723fs*8 (No)	GDSC	Voxtalisib	62.8655
SIDM00629	BRCA\|breast	p.D723fs*8 (No)	GDSC	NU7441	19.7443
SIDM00629	BRCA\|breast	p.D723fs*8 (No)	GDSC	NU7441	40.059
SIDM01129	SCLC\|lung_small_cell_carcinoma	p.S3114F (No)	GDSC	Voxtalisib	86.5572
SIDM01129	SCLC\|lung_small_cell_carcinoma	p.S3114F (No)	GDSC	NU7441	28.2108
SIDM00418	THCA\|thyroid	p.E596Q (No)	GDSC	Voxtalisib	36.3574
SIDM00418	THCA\|thyroid	p.E596Q (No)	GDSC	NU7441	9.0767
SIDM00434	MM\|myeloma	p.R2752Q (No)	GDSC	Voxtalisib	23.0677
SIDM00434	MM\|myeloma	p.R2752Q (No)	GDSC	NU7441	6.1274
SIDM00964	UNCLASSIFIED\|prostate	p.K1360delK (No)	GDSC	Voxtalisib	107.3583
SIDM00964	UNCLASSIFIED\|prostate	p.K1360delK (No)	GDSC	NU7441	5.3292
SIDM00711	SCLC\|lung_small_cell_carcinoma	p.V4003M (No)	GDSC	Voxtalisib	187.5287
SIDM00711	SCLC\|lung_small_cell_carcinoma	p.V4003M (No)	GDSC	NU7441	78.9279
SIDM01201	UNCLASSIFIED\|lymphoid_neoplasm_other	p.Q2300E (No)	GDSC	Voxtalisib	5.992
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.V1549I (No)	GDSC	Voxtalisib	31.6448
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.V1549I (No)	GDSC	NU7441	2.3441
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.T2644S (No)	GDSC	Voxtalisib	21.9483
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.T2644S (No)	GDSC	NU7441	8
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.F446L (No)	GDSC	Voxtalisib	49.2643
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.F446L (No)	GDSC	NU7441	34.5986
SIDM00294	SCLC\|lung_small_cell_carcinoma	p.R3424C (No)	GDSC	Voxtalisib	51.7675
SIDM00294	SCLC\|lung_small_cell_carcinoma	p.R3424C (No)	GDSC	NU7441	7.0859
SIDM00294	SCLC\|lung_small_cell_carcinoma	p.D2859Y (No)	GDSC	Voxtalisib	51.7675
SIDM00294	SCLC\|lung_small_cell_carcinoma	p.D2859Y (No)	GDSC	NU7441	7.0859
SIDM00294	SCLC\|lung_small_cell_carcinoma	p.E2577D (No)	GDSC	Voxtalisib	51.7675
SIDM00294	SCLC\|lung_small_cell_carcinoma	p.E2577D (No)	GDSC	NU7441	7.0859
SIDM00602	STAD\|stomach	p.A1947T (No)	GDSC	Voxtalisib	18.5663
SIDM00602	STAD\|stomach	p.A1947T (No)	GDSC	NU7441	13.8905
SIDM00251	STAD\|stomach	p.M2762fs*1 (No)	GDSC	Voxtalisib	39.1506
SIDM00251	STAD\|stomach	p.M2762fs*1 (No)	GDSC	NU7441	9.5343
SIDM00157	NB\|neuroblastoma	p.H1393Y (No)	GDSC	Voxtalisib	10.9642
SIDM00157	NB\|neuroblastoma	p.H1393Y (No)	GDSC	NU7441	0.5183
SIDM01148	MM\|myeloma	p.H1175Y (No)	GDSC	NU7441	1.0613
SIDM01186	BRCA\|breast	p.V3936M (No)	GDSC	Voxtalisib	414.024
SIDM01186	BRCA\|breast	p.V3936M (No)	GDSC	NU7441	41.2249
SIDM01186	BRCA\|breast	p.V3936M (No)	GDSC	NU7441	59.244
SIDM00441	LAML\|acute_myeloid_leukaemia	p.L1706Q (No)	GDSC	Voxtalisib	45.2878
SIDM00441	LAML\|acute_myeloid_leukaemia	p.L1706Q (No)	GDSC	NU7441	14.6745
SIDM00441	LAML\|acute_myeloid_leukaemia	p.V1478L (No)	GDSC	Voxtalisib	45.2878
SIDM00441	LAML\|acute_myeloid_leukaemia	p.V1478L (No)	GDSC	NU7441	14.6745
SIDM01045	UCEC\|endometrium	p.C1376R (No)	GDSC	Voxtalisib	85.432
SIDM01045	UCEC\|endometrium	p.C1376R (No)	GDSC	NU7441	73.183
SIDM01028	ESCA\|oesophagus	p.M3653R (No)	GDSC	Voxtalisib	281.1758
SIDM01028	ESCA\|oesophagus	p.M3653R (No)	GDSC	NU7441	4.5888
SIDM00946	ALL\|T_cell_leukemia	p.T1181I (No)	GDSC	Voxtalisib	122.0187
SIDM00946	ALL\|T_cell_leukemia	p.T1181I (No)	GDSC	NU7441	3.9482
SIDM01019	LAML\|acute_myeloid_leukaemia	p.R1936G (No)	GDSC	Voxtalisib	18.4223
SIDM01019	LAML\|acute_myeloid_leukaemia	p.R1936G (No)	GDSC	NU7441	2.769
SIDM00303	OV\|ovary	p.A3430S (No)	GDSC	Voxtalisib	41.6357
SIDM00303	OV\|ovary	p.A3430S (No)	GDSC	NU7441	38.0057
SIDM00313	UNCLASSIFIED\|Hodgkin_lymphoma	p.P3200S (Yes)	GDSC	Voxtalisib	58.2367
SIDM00313	UNCLASSIFIED\|Hodgkin_lymphoma	p.P3200S (Yes)	GDSC	NU7441	10.7614
SIDM00333	UCEC\|endometrium	p.L3694M (No)	GDSC	Voxtalisib	51.8381
SIDM00333	UCEC\|endometrium	p.L3694M (No)	GDSC	NU7441	11.4227
SIDM00333	UCEC\|endometrium	p.G3647S (No)	GDSC	Voxtalisib	51.8381
SIDM00333	UCEC\|endometrium	p.G3647S (No)	GDSC	NU7441	11.4227
SIDM01059	SKCM\|melanoma	p.S1162L (No)	GDSC	Voxtalisib	12.6913
SIDM01059	SKCM\|melanoma	p.S1162L (No)	GDSC	NU7441	8.0644
SIDM00401	SKCM\|melanoma	p.P1722L (No)	GDSC	Voxtalisib	29.3505
SIDM00401	SKCM\|melanoma	p.P1722L (No)	GDSC	NU7441	8.588
SIDM00442	THCA\|thyroid	p.P3200S (Yes)	GDSC	Voxtalisib	41.165
SIDM00442	THCA\|thyroid	p.P3200S (Yes)	GDSC	NU7441	5.7284
SIDM00077	HNSC\|head_and_neck	p.A3898V (No)	GDSC	Voxtalisib	262.7797
SIDM00077	HNSC\|head_and_neck	p.A3898V (No)	GDSC	NU7441	17.3663
SIDM00077	HNSC\|head_and_neck	p.L1706Q (No)	GDSC	Voxtalisib	262.7797
SIDM00077	HNSC\|head_and_neck	p.L1706Q (No)	GDSC	NU7441	17.3663
SIDM01126	SCLC\|lung_small_cell_carcinoma	p.G3644W (No)	GDSC	Voxtalisib	30.4301
SIDM01126	SCLC\|lung_small_cell_carcinoma	p.G3644W (No)	GDSC	NU7441	8.1806
SIDM01126	SCLC\|lung_small_cell_carcinoma	p.F3643L (No)	GDSC	Voxtalisib	30.4301
SIDM01126	SCLC\|lung_small_cell_carcinoma	p.F3643L (No)	GDSC	NU7441	8.1806
SIDM00129	SKCM\|melanoma	p.L2779F (No)	GDSC	Voxtalisib	7.8614
SIDM00129	SKCM\|melanoma	p.L2779F (No)	GDSC	NU7441	13.3525
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.V3489I (No)	GDSC	Voxtalisib	78.8765
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.V3489I (No)	GDSC	NU7441	36.6308
SIDM00590	HNSC\|head_and_neck	p.S2532* (No)	GDSC	Voxtalisib	172.1803
SIDM00590	HNSC\|head_and_neck	p.S2532* (No)	GDSC	NU7441	4.1409
SIDM00217	COREAD\|large_intestine	p.R3724W (No)	GDSC	Voxtalisib	169.1451
SIDM00217	COREAD\|large_intestine	p.S3588N (No)	GDSC	Voxtalisib	169.1451
SIDM00217	COREAD\|large_intestine	p.R3473Q (No)	GDSC	Voxtalisib	169.1451
SIDM00217	COREAD\|large_intestine	p.R2914H (No)	GDSC	Voxtalisib	169.1451
SIDM00217	COREAD\|large_intestine	p.R2728H (No)	GDSC	Voxtalisib	169.1451
SIDM00217	COREAD\|large_intestine	p.P2603L (No)	GDSC	Voxtalisib	169.1451
SIDM00217	COREAD\|large_intestine	p.V1772A (No)	GDSC	Voxtalisib	169.1451
SIDM00217	COREAD\|large_intestine	p.V1658I (No)	GDSC	Voxtalisib	169.1451
SIDM00217	COREAD\|large_intestine	p.A1067V (No)	GDSC	Voxtalisib	169.1451
SIDM00217	COREAD\|large_intestine	p.A362G (No)	GDSC	Voxtalisib	169.1451
SIDM00217	COREAD\|large_intestine	p.V252A (No)	GDSC	Voxtalisib	169.1451
SIDM00217	COREAD\|large_intestine	p.E77G (No)	GDSC	Voxtalisib	169.1451
SIDM00821	KIRC\|kidney	p.E889D (No)	GDSC	Voxtalisib	17.1213
SIDM00821	KIRC\|kidney	p.E889D (No)	GDSC	NU7441	5.8832
SIDM00140	SKCM\|melanoma	p.T1702A (No)	GDSC	Voxtalisib	130.0637
SIDM00140	SKCM\|melanoma	p.T1702A (No)	GDSC	NU7441	20.3079
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.L760P (No)	GDSC	Voxtalisib	153.5386
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.L760P (No)	GDSC	NU7441	5.2606
SIDM01120	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.M238V (No)	GDSC	Voxtalisib	36.7978
SIDM01120	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.M238V (No)	GDSC	NU7441	39.7015
SIDM00323	DLBC\|B_cell_lymphoma	p.K927E (No)	GDSC	Voxtalisib	73.9142
SIDM00323	DLBC\|B_cell_lymphoma	p.K927E (No)	GDSC	NU7441	18.5472
SIDM00084	GBM\|glioma	p.G3148D (No)	GDSC	Voxtalisib	135.161
SIDM00084	GBM\|glioma	p.G3148D (No)	GDSC	NU7441	10.0758
SIDM00280	UNCLASSIFIED\|stomach	p.L1080V (No)	GDSC	Voxtalisib	14.9591
SIDM00280	UNCLASSIFIED\|stomach	p.L1080V (No)	GDSC	NU7441	25.0605
SIDM00082	SKCM\|melanoma	p.R3473W (No)	GDSC	Voxtalisib	20.5561
SIDM00082	SKCM\|melanoma	p.R3473W (No)	GDSC	NU7441	12.3331
SIDM00299	UNCLASSIFIED\|soft_tissue_other	p.G2112delG (No)	GDSC	Voxtalisib	66.237
SIDM00299	UNCLASSIFIED\|soft_tissue_other	p.G2112delG (No)	GDSC	NU7441	5.942
SIDM00216	COREAD\|large_intestine	p.A3440V (No)	GDSC	Voxtalisib	21.2501
SIDM00216	COREAD\|large_intestine	p.T2722P (No)	GDSC	Voxtalisib	21.2501
SIDM00216	COREAD\|large_intestine	p.L2240I (No)	GDSC	Voxtalisib	21.2501
SIDM00053	PAAD\|pancreas	p.W1355C (No)	GDSC	Voxtalisib	75.8521
SIDM00053	PAAD\|pancreas	p.W1355C (No)	GDSC	NU7441	22.0862
SIDM00053	PAAD\|pancreas	p.W1355L (No)	GDSC	Voxtalisib	75.8521
SIDM00053	PAAD\|pancreas	p.W1355L (No)	GDSC	NU7441	22.0862
SIDM00053	PAAD\|pancreas	p.F1028V (No)	GDSC	Voxtalisib	75.8521
SIDM00053	PAAD\|pancreas	p.F1028V (No)	GDSC	NU7441	22.0862
SIDM00552	UNCLASSIFIED\|rhabdomyosarcoma	p.K2432I (No)	GDSC	Voxtalisib	43.6878
SIDM00552	UNCLASSIFIED\|rhabdomyosarcoma	p.K2432I (No)	GDSC	NU7441	4.6365
SIDM00492	GBM\|glioma	p.G3677V (No)	GDSC	Voxtalisib	54.2806
SIDM00492	GBM\|glioma	p.G3677V (No)	GDSC	NU7441	7.7913
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.P3200S (Yes)	GDSC	Voxtalisib	66.1257
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.P3200S (Yes)	GDSC	NU7441	27.8055
SIDM00596	UCEC\|endometrium	p.A2160V (No)	GDSC	Voxtalisib	39.396
SIDM00596	UCEC\|endometrium	p.A2160V (No)	GDSC	NU7441	5.2473
SIDM00467	LAML\|acute_myeloid_leukaemia	p.H1458Y (No)	GDSC	Voxtalisib	20.0488
SIDM00467	LAML\|acute_myeloid_leukaemia	p.H1458Y (No)	GDSC	NU7441	3.9345
SIDM00282	COREAD\|large_intestine	p.A4080S (No)	GDSC	Voxtalisib	116.8252
SIDM00282	COREAD\|large_intestine	p.A4080S (No)	GDSC	NU7441	15.7494
SIDM00282	COREAD\|large_intestine	p.V2117M (No)	GDSC	Voxtalisib	116.8252
SIDM00282	COREAD\|large_intestine	p.V2117M (No)	GDSC	NU7441	15.7494
SIDM01088	UNCLASSIFIED\|endometrium	p.N3604fs*3 (No)	GDSC	Voxtalisib	6.3174
SIDM01088	UNCLASSIFIED\|endometrium	p.N3604fs*3 (No)	GDSC	NU7441	21.5196
SIDM00220	OV\|ovary	p.N3604fs*3 (No)	GDSC	Voxtalisib	163.5666
SIDM00220	OV\|ovary	p.N3604fs*3 (No)	GDSC	NU7441	6.6559
SIDM00150	COREAD\|large_intestine	p.L919F (No)	GDSC	Voxtalisib	131.4537
SIDM00150	COREAD\|large_intestine	p.L919F (No)	GDSC	NU7441	9.574
SIDM00150	COREAD\|large_intestine	p.V306I (No)	GDSC	Voxtalisib	131.4537
SIDM00150	COREAD\|large_intestine	p.V306I (No)	GDSC	NU7441	9.574
SIDM00636	MM\|haematopoietic_neoplasm_other	p.R2721P (No)	GDSC	Voxtalisib	28.0345
SIDM00636	MM\|haematopoietic_neoplasm_other	p.R2721P (No)	GDSC	NU7441	2.7789
SIDM00763	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A199T (No)	GDSC	Voxtalisib	113.86
SIDM00763	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A199T (No)	GDSC	NU7441	10.0233
SIDM00474	OV\|ovary	p.P3200S (Yes)	GDSC	Voxtalisib	164.5988
SIDM00474	OV\|ovary	p.P3200S (Yes)	GDSC	NU7441	4.1202
SIDM01050	UNCLASSIFIED\|biliary_tract	p.L217P (No)	GDSC	Voxtalisib	358.2199
SIDM01050	UNCLASSIFIED\|biliary_tract	p.L217P (No)	GDSC	NU7441	6.8408
SIDM00783	COREAD\|large_intestine	p.Y2964C (No)	GDSC	Voxtalisib	108.289
SIDM00783	COREAD\|large_intestine	p.Y2964C (No)	GDSC	NU7441	18.3552
SIDM00925	LUAD\|lung_NSCLC_adenocarcinoma	p.A1594T (No)	GDSC	Voxtalisib	129.8822
SIDM00925	LUAD\|lung_NSCLC_adenocarcinoma	p.A1594T (No)	GDSC	NU7441	82.8787
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.G1227fs*49 (No)	GDSC	Voxtalisib	12.5998
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.G1227fs*49 (No)	GDSC	NU7441	2.262
SIDM00924	UNCLASSIFIED\|lung_NSCLC_not_specified	p.D2072E (No)	GDSC	Voxtalisib	202.5308
SIDM00924	UNCLASSIFIED\|lung_NSCLC_not_specified	p.D2072E (No)	GDSC	NU7441	21.1733
SIDM00954	BRCA\|breast	p.D2936G (No)	GDSC	Voxtalisib	144.7943
SIDM00954	BRCA\|breast	p.D2936G (No)	GDSC	NU7441	30.5052
SIDM00954	BRCA\|breast	p.D2936G (No)	GDSC	NU7441	15.279
SIDM00737	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G2940A (No)	GDSC	Voxtalisib	40.773
SIDM00297	LUAD\|lung_NSCLC_adenocarcinoma	p.S2787G (No)	GDSC	Voxtalisib	90.8606
SIDM00297	LUAD\|lung_NSCLC_adenocarcinoma	p.S2787G (No)	GDSC	NU7441	6.997
SIDM00125	KIRC\|kidney	p.S2882R (No)	GDSC	Voxtalisib	90.8168
SIDM00125	KIRC\|kidney	p.S2882R (No)	GDSC	NU7441	3.7946
SIDM01090	COREAD\|large_intestine	p.L535delL (No)	GDSC	Voxtalisib	62.6047
SIDM01090	COREAD\|large_intestine	p.L535delL (No)	GDSC	NU7441	9.3592
SIDM00658	LUAD\|lung_NSCLC_adenocarcinoma	p.D3813Y (No)	GDSC	Voxtalisib	23.089
SIDM00658	LUAD\|lung_NSCLC_adenocarcinoma	p.D3813Y (No)	GDSC	NU7441	9.7926
SIDM00658	LUAD\|lung_NSCLC_adenocarcinoma	p.D2723Y (No)	GDSC	Voxtalisib	23.089
SIDM00658	LUAD\|lung_NSCLC_adenocarcinoma	p.D2723Y (No)	GDSC	NU7441	9.7926
SIDM00789	COREAD\|large_intestine	p.A2748V (No)	GDSC	Voxtalisib	224.0793
SIDM00789	COREAD\|large_intestine	p.A2748V (No)	GDSC	NU7441	17.3046
SIDM00534	COREAD\|large_intestine	p.E3447D (No)	GDSC	Voxtalisib	109.0545
SIDM00534	COREAD\|large_intestine	p.E3447D (No)	GDSC	NU7441	28.91
SIDM00534	COREAD\|large_intestine	p.E2563K (No)	GDSC	Voxtalisib	109.0545
SIDM00534	COREAD\|large_intestine	p.E2563K (No)	GDSC	NU7441	28.91
SIDM01194	LIHC\|liver	p.G2112delG (No)	GDSC	Voxtalisib	56.7617
SIDM01194	LIHC\|liver	p.G2112delG (No)	GDSC	NU7441	8.817
SIDM00149	SKCM\|melanoma	p.P2603S (No)	GDSC	Voxtalisib	34.127
SIDM00149	SKCM\|melanoma	p.P2603S (No)	GDSC	NU7441	4.4566
SIDM00487	COREAD\|large_intestine	p.N2829fs*16 (No)	GDSC	Voxtalisib	34.8403
SIDM00487	COREAD\|large_intestine	p.N2829fs*16 (No)	GDSC	NU7441	24.2948
SIDM00487	COREAD\|large_intestine	p.Y651C (No)	GDSC	Voxtalisib	34.8403
SIDM00487	COREAD\|large_intestine	p.Y651C (No)	GDSC	NU7441	24.2948
SIDM00632	MM\|myeloma	p.V3513I (No)	GDSC	Voxtalisib	58.3258
SIDM00632	MM\|myeloma	p.V3513I (No)	GDSC	NU7441	10.2686
SIDM00741	SCLC\|lung_small_cell_carcinoma	p.C1918F (No)	GDSC	Voxtalisib	191.5234
SIDM00741	SCLC\|lung_small_cell_carcinoma	p.C1918F (No)	GDSC	NU7441	23.7925
SIDM01041	ESCA\|oesophagus	p.P3200S (Yes)	GDSC	Voxtalisib	82.8558
SIDM01041	ESCA\|oesophagus	p.P3200S (Yes)	GDSC	NU7441	6.7535
SIDM00480	OV\|ovary	p.F2643L (No)	GDSC	Voxtalisib	66.2834
SIDM00480	OV\|ovary	p.F2643L (No)	GDSC	NU7441	5.8513
SIDM00582	PAAD\|pancreas	p.G2261S (No)	GDSC	NU7441	8.3952
SIDM00356	LUAD\|lung_NSCLC_adenocarcinoma	p.G2112delG (No)	GDSC	Voxtalisib	288.8516
SIDM00356	LUAD\|lung_NSCLC_adenocarcinoma	p.G2112delG (No)	GDSC	NU7441	4.6843
SIDM00545	SKCM\|melanoma	p.P2547L (No)	GDSC	Voxtalisib	127.7178
SIDM00545	SKCM\|melanoma	p.P2547L (No)	GDSC	NU7441	49.0402
SIDM00545	SKCM\|melanoma	p.R2451* (No)	GDSC	Voxtalisib	127.7178
SIDM00545	SKCM\|melanoma	p.R2451* (No)	GDSC	NU7441	49.0402
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.M939V (No)	GDSC	Voxtalisib	122.2226
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.M939V (No)	GDSC	NU7441	32.711
SIDM00807	BLCA\|bladder	p.G2112delG (No)	GDSC	Voxtalisib	74.6053
SIDM00807	BLCA\|bladder	p.G2112delG (No)	GDSC	NU7441	8.9017
SIDM01093	CESC\|cervix	p.P3465fs*7 (No)	GDSC	Voxtalisib	81.3372
SIDM01093	CESC\|cervix	p.P3465fs*7 (No)	GDSC	NU7441	29.8311
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.I2325T (No)	GDSC	Voxtalisib	109.2779
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.I2325T (No)	GDSC	NU7441	5.1318
SIDM00659	GBM\|glioma	p.T1350fs*9 (No)	GDSC	Voxtalisib	106.3087
SIDM00659	GBM\|glioma	p.T1350fs*9 (No)	GDSC	NU7441	17.8073
SIDM00528	BRCA\|breast	p.H1303Y (No)	GDSC	Voxtalisib	48.8207
SIDM00528	BRCA\|breast	p.H1303Y (No)	GDSC	NU7441	9.7055
SIDM00528	BRCA\|breast	p.H1303Y (No)	GDSC	NU7441	9.0196
SIDM00078	HNSC\|head_and_neck	p.R1155* (No)	GDSC	Voxtalisib	69.4122
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.A1067V (No)	GDSC	Voxtalisib	72.4925
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.A1067V (No)	GDSC	NU7441	15.4973
SIDM01103	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.P3622S (No)	GDSC	Voxtalisib	106.0704
SIDM01103	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.P3622S (No)	GDSC	NU7441	9.7382
SIDM00980	STAD\|stomach	p.R2703fs*13 (No)	GDSC	Voxtalisib	30.6098
SIDM00980	STAD\|stomach	p.R2703fs*13 (No)	GDSC	NU7441	8.0945
SIDM00364	ALL\|lymphoblastic_leukemia	p.M2024I (No)	GDSC	Voxtalisib	22.1587
SIDM00364	ALL\|lymphoblastic_leukemia	p.M2024I (No)	GDSC	NU7441	3.5951
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.G2632V (No)	GDSC	Voxtalisib	12.5998
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.G2632V (No)	GDSC	NU7441	2.262
SIDM01182	BLCA\|bladder	p.P3200S (Yes)	GDSC	Voxtalisib	42.4548
SIDM01182	BLCA\|bladder	p.P3200S (Yes)	GDSC	NU7441	3.8157
SIDM00927	SCLC\|lung_small_cell_carcinoma	p.K2702E (No)	GDSC	Voxtalisib	31.1727
SIDM00927	SCLC\|lung_small_cell_carcinoma	p.K2702E (No)	GDSC	NU7441	8.9399
SIDM00697	SCLC\|lung_small_cell_carcinoma	p.M4019fs*2 (No)	GDSC	Voxtalisib	45.449
SIDM00697	SCLC\|lung_small_cell_carcinoma	p.M4019fs*2 (No)	GDSC	NU7441	41.2791
SIDM00921	LUAD\|lung_NSCLC_adenocarcinoma	p.A1067V (No)	GDSC	Voxtalisib	38.4959
SIDM00921	LUAD\|lung_NSCLC_adenocarcinoma	p.A1067V (No)	GDSC	NU7441	34.7569
SIDM01060	SKCM\|melanoma	p.H1476Y (No)	GDSC	Voxtalisib	12.4174
SIDM01060	SKCM\|melanoma	p.H1476Y (No)	GDSC	NU7441	9.3207
SIDM00419	UNCLASSIFIED\|ewings_sarcoma	p.P3200S (Yes)	GDSC	Voxtalisib	139.9004
SIDM00419	UNCLASSIFIED\|ewings_sarcoma	p.P3200S (Yes)	GDSC	NU7441	9.198
SIDM01070	UNCLASSIFIED\|lung_NSCLC_not_specified	p.E3610K (No)	GDSC	NU7441	11.9685
SIDM00525	UNCLASSIFIED\|osteosarcoma	p.A3440V (No)	GDSC	Voxtalisib	87.8221
SIDM00525	UNCLASSIFIED\|osteosarcoma	p.A3440V (No)	GDSC	NU7441	5.6084
SIDM00120	PRAD\|prostate	p.N3604fs*3 (No)	GDSC	Voxtalisib	162.6847
SIDM00120	PRAD\|prostate	p.N3604fs*3 (No)	GDSC	NU7441	31.1014
SIDM00203	UNCLASSIFIED\|ewings_sarcoma	p.Q539R (No)	GDSC	NU7441	22.2364
SIDM00654	SCLC\|lung_small_cell_carcinoma	p.R2157H (No)	GDSC	Voxtalisib	49.1849
SIDM00654	SCLC\|lung_small_cell_carcinoma	p.R2157H (No)	GDSC	NU7441	5.4497
SIDM00537	COREAD\|large_intestine	p.V830A (No)	GDSC	Voxtalisib	46.0663
SIDM00537	COREAD\|large_intestine	p.V830A (No)	GDSC	NU7441	14.8175
SIDM00328	ESCA\|oesophagus	p.G2112delG (No)	GDSC	Voxtalisib	41.2121
SIDM00328	ESCA\|oesophagus	p.G2112delG (No)	GDSC	NU7441	19.0965
SIDM00722	MESO\|mesothelioma	p.L1706Q (No)	GDSC	Voxtalisib	65.3784
SIDM00722	MESO\|mesothelioma	p.L1706Q (No)	GDSC	NU7441	11.7822
SIDM00722	MESO\|mesothelioma	p.V1478L (No)	GDSC	Voxtalisib	65.3784
SIDM00722	MESO\|mesothelioma	p.V1478L (No)	GDSC	NU7441	11.7822
SIDM01033	BLCA\|bladder	p.T3414fs*37 (No)	GDSC	Voxtalisib	158.4723
SIDM01033	BLCA\|bladder	p.T3414fs*37 (No)	GDSC	NU7441	1.9691
SIDM00837	COREAD\|large_intestine	p.S75N (No)	GDSC	Voxtalisib	130.301
SIDM00837	COREAD\|large_intestine	p.S75N (No)	GDSC	NU7441	20.0338
SIDM01150	LUAD\|lung_NSCLC_adenocarcinoma	p.P2058A (No)	GDSC	Voxtalisib	291.5656
SIDM01150	LUAD\|lung_NSCLC_adenocarcinoma	p.P2058A (No)	GDSC	NU7441	1.9578
SIDM00115	HNSC\|head_and_neck	p.G2047R (No)	GDSC	Voxtalisib	8.551
SIDM00115	HNSC\|head_and_neck	p.G2047R (No)	GDSC	NU7441	3.5759
SIDM00944	COREAD\|large_intestine	p.M2039V (No)	GDSC	Voxtalisib	209.539
SIDM00944	COREAD\|large_intestine	p.M2039V (No)	GDSC	NU7441	3.9543
SIDM01062	BRCA\|breast	p.M3931L (No)	GDSC	Voxtalisib	215.3854
SIDM01062	BRCA\|breast	p.M3931L (No)	GDSC	NU7441	23.7242
SIDM01062	BRCA\|breast	p.M3931L (No)	GDSC	NU7441	24.559
SIDM00888	MB\|medulloblastoma	p.E1050delE (No)	GDSC	Voxtalisib	22.2688
SIDM00888	MB\|medulloblastoma	p.E1050delE (No)	GDSC	NU7441	3.523
SIDM00878	BRCA\|breast	p.D3618G (No)	GDSC	Voxtalisib	105.6871
SIDM00878	BRCA\|breast	p.D3618G (No)	GDSC	NU7441	23.796
SIDM00878	BRCA\|breast	p.D3618G (No)	GDSC	NU7441	8.3538
SIDM00878	BRCA\|breast	p.A1379T (No)	GDSC	Voxtalisib	105.6871
SIDM00878	BRCA\|breast	p.A1379T (No)	GDSC	NU7441	23.796
SIDM00878	BRCA\|breast	p.A1379T (No)	GDSC	NU7441	8.3538
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.A2160T (No)	GDSC	Voxtalisib	45.8742
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.A2160T (No)	GDSC	NU7441	5.235
SIDM00043	HNSC\|head_and_neck	p.G2047R (No)	GDSC	Voxtalisib	10.0221
SIDM00043	HNSC\|head_and_neck	p.G2047R (No)	GDSC	NU7441	3.9311
SIDM00193	COREAD\|large_intestine	p.E2584K (No)	GDSC	Voxtalisib	56.6765
SIDM00193	COREAD\|large_intestine	p.E2584K (No)	GDSC	NU7441	5.4425
SIDM00193	COREAD\|large_intestine	p.S671Y (No)	GDSC	Voxtalisib	56.6765
SIDM00193	COREAD\|large_intestine	p.S671Y (No)	GDSC	NU7441	5.4425
SIDM00858	UNCLASSIFIED\|osteosarcoma	p.G2112delG (No)	GDSC	Voxtalisib	62.301
SIDM00858	UNCLASSIFIED\|osteosarcoma	p.G2112delG (No)	GDSC	NU7441	11.8797
SIDM00118	COREAD\|large_intestine	p.V3432G (No)	GDSC	Voxtalisib	100.3516
SIDM00118	COREAD\|large_intestine	p.V3432G (No)	GDSC	NU7441	5.3917
SIDM00118	COREAD\|large_intestine	p.L1168P (No)	GDSC	Voxtalisib	100.3516
SIDM00118	COREAD\|large_intestine	p.L1168P (No)	GDSC	NU7441	5.3917
SIDM00118	COREAD\|large_intestine	p.E850* (No)	GDSC	Voxtalisib	100.3516
SIDM00118	COREAD\|large_intestine	p.E850* (No)	GDSC	NU7441	5.3917
SIDM00118	COREAD\|large_intestine	p.L475I (No)	GDSC	Voxtalisib	100.3516
SIDM00118	COREAD\|large_intestine	p.L475I (No)	GDSC	NU7441	5.3917
SIDM00809	HNSC\|head_and_neck	p.P3200S (Yes)	GDSC	Voxtalisib	68.7126
SIDM00832	COREAD\|large_intestine	p.R1075fs*31 (No)	GDSC	Voxtalisib	686.3042
SIDM00832	COREAD\|large_intestine	p.R1075fs*31 (No)	GDSC	NU7441	72.1831

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LTPLPE

Degron related mutations and impact score

Drug responses associated with PRKDC mutations

All proteins holding degron of LTPLPE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P78527	DNA-dependent protein kinase catalytic subunit	DEG_SCF_FBW7_2	3197:3202	LTPLPE	FBXW7	0.7342	More...