DegronMD

Uniprot ID: Q6ZSG1

Source protein: E3 ubiquitin-protein ligase RNF165

Source gene: RNF165

Class: DEG_SCF_FBW7_1

Location: 82:87

E3 ligase: FBXW7

DEGRON score: 0.9369

ASA_SCORE: 51.9

COIL: 0.9147

CONS_SCORE: 0.4802

DSS_SCORE: 0.4403

HELIX: 0.0375

FCONS_SCORE: 1.0494

RIG_SCORE: 0.6961

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D92Y	TCGA-69-7978	LUAD	TCGA	LTPLPT	DEG_SCF_FBW7_1	0.1944
p.D92Y	DO24920	LUAD	ICGC	LTPLPT	DEG_SCF_FBW7_1	0.1944
p.V93I	TCGA-AZ-4615	COAD	TCGA	LTPLPT	DEG_SCF_FBW7_1	0.1667
p.V93I	DO222613	BTCA	ICGC	LTPLPT	DEG_SCF_FBW7_1	0.1667
p.V93I	DO7977	COAD	ICGC	LTPLPT	DEG_SCF_FBW7_1	0.1667
p.P84Q	TCGA-D6-6827	HNSC	TCGA	LTPLPT	DEG_SCF_FBW7_1	0.7035
p.P84Q	DO14169	HNSC	ICGC	LTPLPT	DEG_SCF_FBW7_1	0.7035
p.P84L	TCGA-D7-6526	STAD	TCGA	LTPLPT	DEG_SCF_FBW7_1	0.7582
p.P84L	DO38803	STAD	ICGC	LTPLPT	DEG_SCF_FBW7_1	0.7582
p.P96S	TCGA-EE-A29S	SKCM	TCGA	LTPLPT	DEG_SCF_FBW7_1	0.0833
p.P96S	DO37936	SKCM	ICGC	LTPLPT	DEG_SCF_FBW7_1	0.0833
p.P96S	SIDM00545	Melanoma	GDSC	LTPLPT	DEG_SCF_FBW7_1	0.0833
p.P96S	ACH-000987	Skin Cancer	CCLE	LTPLPT	DEG_SCF_FBW7_1	0.0833
p.P96S	Mewo	skin	COSMIC	LTPLPT	DEG_SCF_FBW7_1	0.0833
p.G95C	TCGA-VQ-A8P2	STAD	TCGA	LTPLPT	DEG_SCF_FBW7_1	0.1111
p.G95C	DO51761	STAD	ICGC	LTPLPT	DEG_SCF_FBW7_1	0.1111
p.A77T	DO233731	GACA	ICGC	LTPLPT	DEG_SCF_FBW7_1	0.1944
p.A77T	SIDM00845	Burkitt's Lymphoma	GDSC	LTPLPT	DEG_SCF_FBW7_1	0.1944
p.A77T	ACH-000786	Lymphoma	CCLE	LTPLPT	DEG_SCF_FBW7_1	0.1944
p.A77T	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	LTPLPT	DEG_SCF_FBW7_1	0.1944
p.G86V	DO229022	LICA	ICGC	LTPLPT	DEG_SCF_FBW7_1	0.7532
p.D85N	DO222363	MELA	ICGC	LTPLPT	DEG_SCF_FBW7_1	0.6932
p.P75T	DO37921	SKCM	ICGC	LTPLPT	DEG_SCF_FBW7_1	0.1389
p.S97P	DO229272	THCA	ICGC	LTPLPT	DEG_SCF_FBW7_1	0.0556
p.G88C	DO42568	UCEC	ICGC	LTPLPT	DEG_SCF_FBW7_1	0.3056
p.Q73K	SIDM02015	Colorectal Carcinoma	GDSC	LTPLPT	DEG_SCF_FBW7_1	0.0833
p.L78M	SIDM00781	Colorectal Carcinoma	GDSC	LTPLPT	DEG_SCF_FBW7_1	0.2222
p.L78M	ACH-001199	Colon/Colorectal Cancer	CCLE	LTPLPT	DEG_SCF_FBW7_1	0.2222
p.L78M	SNU-C2B	large_intestine	COSMIC	LTPLPT	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZSG1	E3 ubiquitin-protein ligase RNF165	DEG_SCF_FBW7_1	82:87	LTPLPT	FBXW7	0.9369	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LTPLPT

Degron related mutations and impact score

Drug responses associated with RNF165 mutations

All proteins holding degron of LTPLPT