DegronMD

Uniprot ID: P17036

Source protein: Zinc finger protein 3

Source gene: ZNF3

Class: DEG_SCF_FBW7_2

Location: 164:169

E3 ligase: FBXW7

DEGRON score: 0.939

ASA_SCORE: 89.0167

COIL: 0.8373

CONS_SCORE: 0.475

DSS_SCORE: 0.5525

HELIX: 0.0208

FCONS_SCORE: 0.8425

RIG_SCORE: 0.7058

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P166S	TCGA-AA-3877	COAD	TCGA	LTPRGE	DEG_SCF_FBW7_2	0.6752
p.P166S	DO7855	COAD	ICGC	LTPRGE	DEG_SCF_FBW7_2	0.6752
p.K173R	TCGA-DF-A2KU	UCEC	TCGA	LTPRGE	DEG_SCF_FBW7_2	0.6667
p.K173R	DO223286	UCEC	ICGC	LTPRGE	DEG_SCF_FBW7_2	0.6667
p.V158A	TCGA-DU-6392	LGG	TCGA	LTPRGE	DEG_SCF_FBW7_2	0.1667
p.V158A	DO22237	LGG	ICGC	LTPRGE	DEG_SCF_FBW7_2	0.1667
p.E161K	TCGA-EK-A2IP	CESC	TCGA	LTPRGE	DEG_SCF_FBW7_2	0.25
p.E161K	DO48978	CESC	ICGC	LTPRGE	DEG_SCF_FBW7_2	0.25
p.E172K	TCGA-EO-A22X	UCEC	TCGA	LTPRGE	DEG_SCF_FBW7_2	0.25
p.E172K	DO43907	UCEC	ICGC	LTPRGE	DEG_SCF_FBW7_2	0.25
p.G178A	DO1125	BRCA	ICGC	LTPRGE	DEG_SCF_FBW7_2	0.0833
p.E162K	DO229140	THCA	ICGC	LTPRGE	DEG_SCF_FBW7_2	0.2778
p.T165I	SIDM00189	Melanoma	GDSC	LTPRGE	DEG_SCF_FBW7_2	0.8189
p.T165I	ACH-002098	Skin Cancer	CCLE	LTPRGE	DEG_SCF_FBW7_2	0.8189
p.T165I	CP67-MEL	skin	COSMIC	LTPRGE	DEG_SCF_FBW7_2	0.8189

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17036	Zinc finger protein 3	DEG_SCF_FBW7_2	164:169	LTPRGE	FBXW7	0.939	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons