DegronMD

Uniprot ID: Q76KP1

Source protein: N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1

Source gene: B4GALNT4

Class: DEG_SCF_FBW7_2

Location: 328:333

E3 ligase: FBXW7

DEGRON score: 0.9752

ASA_SCORE: 47.7333

COIL: 0.7102

CONS_SCORE: 0.3952

DSS_SCORE: 0.4734

HELIX: 0.0442

FCONS_SCORE: 0.9012

RIG_SCORE: 0.7549

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N339S	TCGA-5M-AAT6	COAD	TCGA	LTPRME	DEG_SCF_FBW7_2	0.1667
p.N339S	DO223703	COAD	ICGC	LTPRME	DEG_SCF_FBW7_2	0.1667
p.N339S	DO218900	SKCA	ICGC	LTPRME	DEG_SCF_FBW7_2	0.1667
p.L341M	TCGA-AP-A059	UCEC	TCGA	LTPRME	DEG_SCF_FBW7_2	0.1111
p.L341M	DO41361	UCEC	ICGC	LTPRME	DEG_SCF_FBW7_2	0.1111
p.D324G	TCGA-BH-A18G	BRCA	TCGA	LTPRME	DEG_SCF_FBW7_2	0.2222
p.D324G	DO3686	BRCA	ICGC	LTPRME	DEG_SCF_FBW7_2	0.2222
p.E338D	TCGA-IB-7651	PAAD	TCGA	LTPRME	DEG_SCF_FBW7_2	0.1944
p.E338D	DO46657	PAAD	ICGC	LTPRME	DEG_SCF_FBW7_2	0.1944
p.L337Q	DO231992	LICA	ICGC	LTPRME	DEG_SCF_FBW7_2	0.2222
p.S334F	DO229177	LMS	ICGC	LTPRME	DEG_SCF_FBW7_2	0.3056
p.P322S	DO222653	MELA	ICGC	LTPRME	DEG_SCF_FBW7_2	0.1667
p.P322S	DO38129	SKCM	ICGC	LTPRME	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q76KP1	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1	DEG_SCF_FBW7_2	328:333	LTPRME	FBXW7	0.9752	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons