DegronMD

Uniprot ID: P48454

Source protein: Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

Source gene: PPP3CC

Class: DEG_SCF_FBW7_1

Location: 420:425

E3 ligase: FBXW7

DEGRON score: 0.8405

ASA_SCORE: 65.5667

COIL: 0.8653

CONS_SCORE: 0.3333

DSS_SCORE: 0.2324

HELIX: 0.0468

FCONS_SCORE: 0.8019

RIG_SCORE: 0.752

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R417Q	TCGA-A5-A0G2	UCEC	TCGA	LTPTGT	DEG_SCF_FBW7_1	0.25
p.L435F	TCGA-AX-A2IN	UCEC	TCGA	LTPTGT	DEG_SCF_FBW7_1	0.1667
p.L426F	DO42328	UCEC	ICGC	LTPTGT	DEG_SCF_FBW7_1	0.3056
p.P427S	DO41903	UCEC	ICGC	LTPTGT	DEG_SCF_FBW7_1	0.2778
p.S414L	SIDM00025	Head and Neck Carcinoma	GDSC	LTPTGT	DEG_SCF_FBW7_1	0.1667
p.S414L	UDSCC2	upper_aerodigestive_tract	COSMIC	LTPTGT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48454	Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform	DEG_SCF_FBW7_1	420:425	LTPTGT	FBXW7	0.8405	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons