DegronMD

Uniprot ID: Q96AP7

Source protein: Endothelial cell-selective adhesion molecule

Source gene: ESAM

Class: DEG_SCF_FBW7_1

Location: 331:338

E3 ligase: FBXW7

DEGRON score: 0.9968

ASA_SCORE: 82.05

COIL: 0.921

CONS_SCORE: 0.5523

DSS_SCORE: 0.8002

HELIX: 0.0353

FCONS_SCORE: 1.166

RIG_SCORE: 0.5839

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R346G	TCGA-CK-4951	COAD	TCGA	LTPTPSLS	DEG_SCF_FBW7_1	0.1111
p.R346G	DO10582	COAD	ICGC	LTPTPSLS	DEG_SCF_FBW7_1	0.1111
p.A341T	TCGA-E6-A1LX	UCEC	TCGA	LTPTPSLS	DEG_SCF_FBW7_1	0.25
p.A341T	DO41020	UCEC	ICGC	LTPTPSLS	DEG_SCF_FBW7_1	0.25
p.G329D	TCGA-EO-A22R	UCEC	TCGA	LTPTPSLS	DEG_SCF_FBW7_1	0.2778
p.G329D	DO42713	UCEC	ICGC	LTPTPSLS	DEG_SCF_FBW7_1	0.2778
p.G329D	SIDM02039	Colorectal Carcinoma	GDSC	LTPTPSLS	DEG_SCF_FBW7_1	0.2778
p.P348S	TCGA-FI-A2D0	UCEC	TCGA	LTPTPSLS	DEG_SCF_FBW7_1	0.0556
p.P348S	DO43891	UCEC	ICGC	LTPTPSLS	DEG_SCF_FBW7_1	0.0556
p.P325S	TCGA-FR-A729	SKCM	TCGA	LTPTPSLS	DEG_SCF_FBW7_1	0.1667
p.P325S	DO48618	SKCM	ICGC	LTPTPSLS	DEG_SCF_FBW7_1	0.1667
p.S338C	TCGA-ZF-A9RF	BLCA	TCGA	LTPTPSLS	DEG_SCF_FBW7_1	0.643
p.S338C	DO219074	BLCA	ICGC	LTPTPSLS	DEG_SCF_FBW7_1	0.643
p.T334M	DO229003	COCA	ICGC	LTPTPSLS	DEG_SCF_FBW7_1	0.7423
p.P328H	DO231965	LICA	ICGC	LTPTPSLS	DEG_SCF_FBW7_1	0.25
p.L337I	DO229009	LICA	ICGC	LTPTPSLS	DEG_SCF_FBW7_1	0.6063
p.G329S	SIDM00510	Small Cell Lung Carcinoma	GDSC	LTPTPSLS	DEG_SCF_FBW7_1	0.2778
p.G329S	ACH-002095	Lung Cancer	CCLE	LTPTPSLS	DEG_SCF_FBW7_1	0.2778
p.G329S	COR-L303	lung	COSMIC	LTPTPSLS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96AP7	Endothelial cell-selective adhesion molecule	DEG_SCF_FBW7_1	331:338	LTPTPSLS	FBXW7	0.9968	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons