DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LTPVAE
Uniprot ID:
A8MYA2
Source protein:
Uncharacterized protein CXorf49
Source gene:
CXorf49; CXorf49B
Class:
DEG_SCF_FBW7_2
Location:
266:271
E3 ligase:
FBXW7
DEGRON score:
0.9998
ASA_SCORE:
73.7833
COIL:
0.7242
CONS_SCORE:
0.7049
DSS_SCORE:
0.5074
HELIX:
0.153
FCONS_SCORE:
1.3328
RIG_SCORE:
0.7181
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with CXorf49; CXorf49B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LTPVAE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A8MYA2
Uncharacterized protein CXorf49
DEG_SCF_FBW7_2
266:271
LTPVAE
FBXW7
0.9998
More...