DegronMD

Uniprot ID: P27694

Source protein: Replication protein A 70 kDa DNA-binding subunit

Source gene: RPA1

Class: DEG_SCF_FBW7_1

Location: 190:195

E3 ligase: FBXW7

DEGRON score: 0.915

ASA_SCORE: 48.6333

COIL: 0.8303

CONS_SCORE: 0.5631

DSS_SCORE: 0.1974

HELIX: 0.0423

FCONS_SCORE: 1.0097

RIG_SCORE: 0.8161

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q181E	TCGA-DM-A1HB	COAD	TCGA	LTPYQS	DEG_SCF_FBW7_1	0.0833
p.A188T	DO228627	GACA	ICGC	LTPYQS	DEG_SCF_FBW7_1	0.2778
p.W197L	DO229041	LICA	ICGC	LTPYQS	DEG_SCF_FBW7_1	0.2778
p.P192L	DO45159	LIRI	ICGC	LTPYQS	DEG_SCF_FBW7_1	0.7582
p.T204S	SIDM01007	T-Lymphoblastic Leukemia	GDSC	LTPYQS	DEG_SCF_FBW7_1	0.0833
p.T204S	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	LTPYQS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P27694	Replication protein A 70 kDa DNA-binding subunit	DEG_SCF_FBW7_1	190:195	LTPYQS	FBXW7	0.915	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons