DegronMD

Uniprot ID: Q99743

Source protein: Neuronal PAS domain-containing protein 2

Source gene: NPAS2

Class: DEG_SCF_FBW7_1

Location: 647:653

E3 ligase: FBXW7

DEGRON score: 0.9976

ASA_SCORE: 78.8

COIL: 0.9479

CONS_SCORE: 0.27

DSS_SCORE: 0.6302

HELIX: 0.0237

FCONS_SCORE: 0.6841

RIG_SCORE: 0.6474

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N646S	TCGA-77-A5GH	LUSC	TCGA	LTTPAST	DEG_SCF_FBW7_1	0.3056
p.N646S	DO45452	LUSC	ICGC	LTTPAST	DEG_SCF_FBW7_1	0.3056
p.A639D	TCGA-BR-8360	STAD	TCGA	LTTPAST	DEG_SCF_FBW7_1	0.1111
p.A639D	DO47745	STAD	ICGC	LTTPAST	DEG_SCF_FBW7_1	0.1111
p.A640T	DO227802	COCA	ICGC	LTTPAST	DEG_SCF_FBW7_1	0.1389
p.Q655H	DO229035	LICA	ICGC	LTTPAST	DEG_SCF_FBW7_1	0.2778
p.A637S	DO229038	LICA	ICGC	LTTPAST	DEG_SCF_FBW7_1	0.0556
p.N646H	DO48746	LIRI	ICGC	LTTPAST	DEG_SCF_FBW7_1	0.3056
p.Q659H	DO51531	PACA	ICGC	LTTPAST	DEG_SCF_FBW7_1	0.1667
p.A640V	SIDM01611	Endometrial Carcinoma	GDSC	LTTPAST	DEG_SCF_FBW7_1	0.1389
p.A640V	ACH-000996	Endometrial/Uterine Cancer	CCLE	LTTPAST	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99743	Neuronal PAS domain-containing protein 2	DEG_SCF_FBW7_1	647:653	LTTPAST	FBXW7	0.9976	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons