DegronMD

Uniprot ID: O15370

Source protein: Transcription factor SOX-12

Source gene: SOX12

Class: DEG_SCF_FBW7_2

Location: 178:185

E3 ligase: FBXW7

DEGRON score: 0.8038

ASA_SCORE: 92.0875

COIL: 0.7796

CONS_SCORE: 0.3556

DSS_SCORE: 0.4446

HELIX: 0.1715

FCONS_SCORE: 1.0447

RIG_SCORE: 0.768

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G193V	DO228976	LICA	ICGC	LVETPGRE	DEG_SCF_FBW7_2	0.1111
p.A192V	DO229229	THCA	ICGC	LVETPGRE	DEG_SCF_FBW7_2	0.1389
p.V176L	DO231298	THCA	ICGC	LVETPGRE	DEG_SCF_FBW7_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15370	Transcription factor SOX-12	DEG_SCF_FBW7_2	178:185	LVETPGRE	FBXW7	0.8038	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons