DegronMD

Uniprot ID: Q8TAF7

Source protein: Zinc finger protein 461

Source gene: ZNF461

Class: LIG_APCC_ABBA_1

Location: 5:10

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8233

ASA_SCORE: 75.6667

COIL: 0.2838

CONS_SCORE: 0.4583

DSS_SCORE: 0.279

HELIX: 0.0042

FCONS_SCORE: 1.2424

RIG_SCORE: 0.8806

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D10Y	TCGA-18-3411	LUSC	TCGA	LVMFRD	LIG_APCC_ABBA_1	0.7325
p.D10Y	DO26758	LUSC	ICGC	LVMFRD	LIG_APCC_ABBA_1	0.7325
p.D10Y	SIDM00387	Neuroblastoma	GDSC	LVMFRD	LIG_APCC_ABBA_1	0.7325
p.D10Y	ACH-000078	Neuroblastoma	CCLE	LVMFRD	LIG_APCC_ABBA_1	0.7325
p.D10Y	MHH-NB-11	autonomic_ganglia	COSMIC	LVMFRD	LIG_APCC_ABBA_1	0.7325
p.M7L	TCGA-97-8175	LUAD	TCGA	LVMFRD	LIG_APCC_ABBA_1	0.5999
p.M7L	DO45376	LUAD	ICGC	LVMFRD	LIG_APCC_ABBA_1	0.5999
p.H3Y	TCGA-AP-A1DV	UCEC	TCGA	LVMFRD	LIG_APCC_ABBA_1	0.2778
p.H3Y	DO43186	UCEC	ICGC	LVMFRD	LIG_APCC_ABBA_1	0.2778
p.E4K	DO225072	BRCA	ICGC	LVMFRD	LIG_APCC_ABBA_1	0.3056
p.E4K	DO227701	BRCA	ICGC	LVMFRD	LIG_APCC_ABBA_1	0.3056
p.E19D	DO50406	ESAD	ICGC	LVMFRD	LIG_APCC_ABBA_1	0.0833
p.D10N	DO50329	ESAD	ICGC	LVMFRD	LIG_APCC_ABBA_1	0.6932
p.R9T	SIDM00676	Bladder Carcinoma	GDSC	LVMFRD	LIG_APCC_ABBA_1	0.6765
p.R9T	ACH-000547	Bladder Cancer	CCLE	LVMFRD	LIG_APCC_ABBA_1	0.6765
p.R9T	HT-1197	urinary_tract	COSMIC	LVMFRD	LIG_APCC_ABBA_1	0.6765
p.E19G	SIDM00516	Melanoma	GDSC	LVMFRD	LIG_APCC_ABBA_1	0.0833
p.E19G	ACH-002166	Skin Cancer	CCLE	LVMFRD	LIG_APCC_ABBA_1	0.0833
p.E19G	MZ7-mel	skin	COSMIC	LVMFRD	LIG_APCC_ABBA_1	0.0833
p.A2T	SIDM01612	Endometrial Carcinoma	GDSC	LVMFRD	LIG_APCC_ABBA_1	0.25
p.A2T	ACH-000946	Endometrial/Uterine Cancer	CCLE	LVMFRD	LIG_APCC_ABBA_1	0.25
p.A2V	ACH-001719	Ovarian Cancer	CCLE	LVMFRD	LIG_APCC_ABBA_1	0.25
p.E5K	BEN	lung	COSMIC	LVMFRD	LIG_APCC_ABBA_1	0.7022
p.E8K	ALL-PO	haematopoietic_and_lymphoid_tissue	COSMIC	LVMFRD	LIG_APCC_ABBA_1	0.7022
p.F13S	NAMALWA	haematopoietic_and_lymphoid_tissue	COSMIC	LVMFRD	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TAF7	Zinc finger protein 461	LIG_APCC_ABBA_1	5:10	LVMFRD	APC,CDC20,FZR1	0.8233	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons