DegronMD

Uniprot ID: Q9BQ95

Source protein: Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

Source gene: ECSIT

Class: LIG_APCC_ABBA_1

Location: 69:74

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9336

ASA_SCORE: 67

COIL: 0.479

CONS_SCORE: 0.4103

DSS_SCORE: 0.6161

HELIX: 0.4408

FCONS_SCORE: 1.1364

RIG_SCORE: 0.7726

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R64M	TCGA-B5-A11E	UCEC	TCGA	LVPFED	LIG_APCC_ABBA_1	0.1944
p.R64M	DO41644	UCEC	ICGC	LVPFED	LIG_APCC_ABBA_1	0.1944
p.R64M	ACH-000947	Ovarian Cancer	CCLE	LVPFED	LIG_APCC_ABBA_1	0.1944
p.A79V	TCGA-L5-A4OI	ESCA	TCGA	LVPFED	LIG_APCC_ABBA_1	0.1944
p.P80L	DO8858	COAD	ICGC	LVPFED	LIG_APCC_ABBA_1	0.1667
p.P65H	DO228974	LICA	ICGC	LVPFED	LIG_APCC_ABBA_1	0.2222
p.R69Q	TGBC24TKB	biliary_tract	COSMIC	LVPFED	LIG_APCC_ABBA_1	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BQ95	Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial	LIG_APCC_ABBA_1	69:74	LVPFED	APC,CDC20,FZR1	0.9336	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons