DegronMD

Uniprot ID: Q8TF40

Source protein: Folliculin-interacting protein 1

Source gene: FNIP1

Class: LIG_APCC_ABBA_1

Location: 912:917

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7978

ASA_SCORE: 65.15

COIL: 0.5855

CONS_SCORE: 0.262

DSS_SCORE: 0.5345

HELIX: 0.0275

FCONS_SCORE: 0.9871

RIG_SCORE: 0.7123

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I925F	TCGA-77-8148	LUSC	TCGA	LVPHGD	LIG_APCC_ABBA_1	0.1111
p.L912F	TCGA-AJ-A3EL	UCEC	TCGA	LVPHGD	LIG_APCC_ABBA_1	0.587
p.A926V	TCGA-CK-5916	COAD	TCGA	LVPHGD	LIG_APCC_ABBA_1	0.0833
p.I925N	TCGA-D3-A8GM	SKCM	TCGA	LVPHGD	LIG_APCC_ABBA_1	0.1111
p.I925N	SIDM00845	Burkitt's Lymphoma	GDSC	LVPHGD	LIG_APCC_ABBA_1	0.1111
p.I925N	SIDM00461	Acute Myeloid Leukemia	GDSC	LVPHGD	LIG_APCC_ABBA_1	0.1111
p.I925N	SIDM01519	Head and Neck Carcinoma	GDSC	LVPHGD	LIG_APCC_ABBA_1	0.1111
p.G916W	TCGA-EE-A29E	SKCM	TCGA	LVPHGD	LIG_APCC_ABBA_1	0.6714
p.K923N	TCGA-EO-A22U	UCEC	TCGA	LVPHGD	LIG_APCC_ABBA_1	0.2778
p.E919D	TCGA-FI-A2D5	UCEC	TCGA	LVPHGD	LIG_APCC_ABBA_1	0.2778
p.L915F	DO50330	ESAD	ICGC	LVPHGD	LIG_APCC_ABBA_1	0.6981
p.D917N	DO13863	GBM	ICGC	LVPHGD	LIG_APCC_ABBA_1	0.6932
p.T923I	DO45223	LIRI	ICGC	LVPHGD	LIG_APCC_ABBA_1	0.2778
p.S913N	DO220876	MELA	ICGC	LVPHGD	LIG_APCC_ABBA_1	0.7069
p.V927I	SIDM00608	Plasma Cell Myeloma	GDSC	LVPHGD	LIG_APCC_ABBA_1	0.0556
p.V927I	SIDM00157	Neuroblastoma	GDSC	LVPHGD	LIG_APCC_ABBA_1	0.0556
p.V927I	SIDM00556	Neuroblastoma	GDSC	LVPHGD	LIG_APCC_ABBA_1	0.0556
p.V927I	SIDM00240	Cervical Carcinoma	GDSC	LVPHGD	LIG_APCC_ABBA_1	0.0556
p.V927I	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	LVPHGD	LIG_APCC_ABBA_1	0.0556
p.V927I	SIDM01472	Hepatocellular Carcinoma	GDSC	LVPHGD	LIG_APCC_ABBA_1	0.0556
p.D904E	SIDM00391	Plasma Cell Myeloma	GDSC	LVPHGD	LIG_APCC_ABBA_1	0.1111
p.M927I	RO82-W-1	thyroid	COSMIC	LVPHGD	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TF40	Folliculin-interacting protein 1	LIG_APCC_ABBA_1	912:917	LVPHGD	APC,CDC20,FZR1	0.7978	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons