DegronMD

Uniprot ID: Q96LX8

Source protein: Zinc finger protein 597

Source gene: ZNF597

Class: LIG_APCC_ABBA_1

Location: 86:91

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9205

ASA_SCORE: 100.1333

COIL: 0.8958

CONS_SCORE: 0.4988

DSS_SCORE: 0.4407

HELIX: 0.0242

FCONS_SCORE: 0.9218

RIG_SCORE: 0.7136

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A76T	TCGA-AA-A02E	COAD	TCGA	LVPYPE	LIG_APCC_ABBA_1	0.0556
p.E95D	TCGA-AX-A05Z	UCEC	TCGA	LVPYPE	LIG_APCC_ABBA_1	0.2222
p.E95D	DO40884	UCEC	ICGC	LVPYPE	LIG_APCC_ABBA_1	0.2222
p.I82M	TCGA-CM-4752	COAD	TCGA	LVPYPE	LIG_APCC_ABBA_1	0.2222
p.I82M	DO9322	COAD	ICGC	LVPYPE	LIG_APCC_ABBA_1	0.2222
p.P88S	TCGA-D9-A6EC	SKCM	TCGA	LVPYPE	LIG_APCC_ABBA_1	0.6752
p.P88S	DO50291	SKCM	ICGC	LVPYPE	LIG_APCC_ABBA_1	0.6752
p.S93F	TCGA-EE-A29D	SKCM	TCGA	LVPYPE	LIG_APCC_ABBA_1	0.2778
p.S93F	TCGA-WE-AAA0	SKCM	TCGA	LVPYPE	LIG_APCC_ABBA_1	0.2778
p.S93F	DO51294	SKCM	ICGC	LVPYPE	LIG_APCC_ABBA_1	0.2778
p.S93F	DO38123	SKCM	ICGC	LVPYPE	LIG_APCC_ABBA_1	0.2778
p.P90S	DO222638	MELA	ICGC	LVPYPE	LIG_APCC_ABBA_1	0.5641
p.P90A	SIDM00698	Small Cell Lung Carcinoma	GDSC	LVPYPE	LIG_APCC_ABBA_1	0.6392
p.P90A	SIDM01001	Breast Carcinoma	GDSC	LVPYPE	LIG_APCC_ABBA_1	0.6392

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96LX8	Zinc finger protein 597	LIG_APCC_ABBA_1	86:91	LVPYPE	APC,CDC20,FZR1	0.9205	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons