DegronMD

Uniprot ID: Q9BQA1

Source protein: Methylosome protein 50

Source gene: WDR77

Class: LIG_APCC_ABBA_1

Location: 58:63

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9806

ASA_SCORE: 48.0667

COIL: 0.3592

CONS_SCORE: 0.4173

DSS_SCORE: 0.0583

HELIX: 0.1023

FCONS_SCORE: 1.2815

RIG_SCORE: 0.9029

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G56A	TCGA-69-7979	LUAD	TCGA	LWLFKD	LIG_APCC_ABBA_1	0.2778
p.G56A	DO23874	LUAD	ICGC	LWLFKD	LIG_APCC_ABBA_1	0.2778
p.P64L	TCGA-CV-7242	HNSC	TCGA	LWLFKD	LIG_APCC_ABBA_1	0.3056
p.P64L	DO14974	HNSC	ICGC	LWLFKD	LIG_APCC_ABBA_1	0.3056
p.D63N	TCGA-EO-A22X	UCEC	TCGA	LWLFKD	LIG_APCC_ABBA_1	0.6932
p.D63N	DO43907	UCEC	ICGC	LWLFKD	LIG_APCC_ABBA_1	0.6932
p.F72L	TCGA-UY-A9PB	BLCA	TCGA	LWLFKD	LIG_APCC_ABBA_1	0.0833
p.F72L	DO219041	BLCA	ICGC	LWLFKD	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BQA1	Methylosome protein 50	LIG_APCC_ABBA_1	58:63	LWLFKD	APC,CDC20,FZR1	0.9806	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons