DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LYHTPPGS
Uniprot ID:
O95397
Source protein:
Putative protein PLEKHA9
Source gene:
PLEKHA8P1
Class:
DEG_SCF_FBW7_1
Location:
66:73
E3 ligase:
FBXW7
DEGRON score:
0.9646
ASA_SCORE:
73.1875
COIL:
0.8699
CONS_SCORE:
0.2838
DSS_SCORE:
0.3226
HELIX:
0.0799
FCONS_SCORE:
0.9137
RIG_SCORE:
0.7153
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with PLEKHA8P1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LYHTPPGS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O95397
Putative protein PLEKHA9
DEG_SCF_FBW7_1
66:73
LYHTPPGS
FBXW7
0.9646
More...