DegronMD

Uniprot ID: Q9Y2T4

Source protein: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform

Source gene: PPP2R2C

Class: LIG_APCC_ABBA_1

Location: 435:440

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6083

ASA_SCORE: 21.0167

COIL: 0.075

CONS_SCORE: 0.5498

DSS_SCORE: 0.1311

HELIX: 0.0012

FCONS_SCORE: 1.3234

RIG_SCORE: 0.9017

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M446V	TCGA-AD-5900	COAD	TCGA	LYIFQD	LIG_APCC_ABBA_1	0.1667
p.N433K	TCGA-EK-A2PL	CESC	TCGA	LYIFQD	LIG_APCC_ABBA_1	0.2778
p.A431T	TCGA-XF-A8HF	BLCA	TCGA	LYIFQD	LIG_APCC_ABBA_1	0.2222
p.N426K	DO48979	CESC	ICGC	LYIFQD	LIG_APCC_ABBA_1	0.0833
p.M439V	DO8514	COAD	ICGC	LYIFQD	LIG_APCC_ABBA_1	0.7208

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2T4	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform	LIG_APCC_ABBA_1	435:440	LYIFQD	APC,CDC20,FZR1	0.6083	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons