DegronMD

Uniprot ID: Q6DJT9

Source protein: Zinc finger protein PLAG1

Source gene: PLAG1

Class: DEG_SCF_FBW7_1

Location: 290:297

E3 ligase: FBXW7

DEGRON score: 0.9692

ASA_SCORE: 78.6875

COIL: 0.6806

CONS_SCORE: 0.9251

DSS_SCORE: 0.3322

HELIX: 0.0716

FCONS_SCORE: 1.0198

RIG_SCORE: 0.7856

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L286V	TCGA-EO-A22R	UCEC	TCGA	LYNTPFQS	DEG_SCF_FBW7_1	0.2222
p.L286V	DO42713	UCEC	ICGC	LYNTPFQS	DEG_SCF_FBW7_1	0.2222
p.L290F	TCGA-KB-A6F7	STAD	TCGA	LYNTPFQS	DEG_SCF_FBW7_1	0.6981
p.L290F	DO50129	STAD	ICGC	LYNTPFQS	DEG_SCF_FBW7_1	0.6981
p.Q296E	DO228272	BRCA	ICGC	LYNTPFQS	DEG_SCF_FBW7_1	0.5633
p.H305Y	DO228272	BRCA	ICGC	LYNTPFQS	DEG_SCF_FBW7_1	0.1111
p.S303C	DO228949	LICA	ICGC	LYNTPFQS	DEG_SCF_FBW7_1	0.1667
p.N289K	DO50784	LICA	ICGC	LYNTPFQS	DEG_SCF_FBW7_1	0.3056
p.P294L	DO222837	MELA	ICGC	LYNTPFQS	DEG_SCF_FBW7_1	0.7582
p.T285S	SIDM01775	B-Cell Non-Hodgkin's Lymphoma	GDSC	LYNTPFQS	DEG_SCF_FBW7_1	0.1944
p.S303Y	ACH-001548	Neuroblastoma	CCLE	LYNTPFQS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6DJT9	Zinc finger protein PLAG1	DEG_SCF_FBW7_1	290:297	LYNTPFQS	FBXW7	0.9692	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons