DegronMD

Uniprot ID: A6NNT2

Source protein: Uncharacterized protein C16orf96

Source gene: C16orf96

Class: LIG_APCC_ABBA_1

Location: 996:1001

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7772

ASA_SCORE: 67.65

COIL: 0.8563

CONS_SCORE: 0.3664

DSS_SCORE: 0.071

HELIX: 0.0263

FCONS_SCORE: 1.0805

RIG_SCORE: 0.8083

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1000R	TCGA-AG-A020	READ	TCGA	LYPYGD	LIG_APCC_ABBA_1	0.6457
p.G1000R	DO36451	READ	ICGC	LYPYGD	LIG_APCC_ABBA_1	0.6457
p.T995M	DO230323	COCA	ICGC	LYPYGD	LIG_APCC_ABBA_1	0.3056
p.T995M	ACH-000936	Ovarian Cancer	CCLE	LYPYGD	LIG_APCC_ABBA_1	0.3056
p.P1002S	DO23268	LINC	ICGC	LYPYGD	LIG_APCC_ABBA_1	0.3056
p.V1004M	DO41199	UCEC	ICGC	LYPYGD	LIG_APCC_ABBA_1	0.25

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NNT2	Uncharacterized protein C16orf96	LIG_APCC_ABBA_1	996:1001	LYPYGD	APC,CDC20,FZR1	0.7772	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons