DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
LYPYGD
Uniprot ID:
A6NNT2
Source protein:
Uncharacterized protein C16orf96
Source gene:
C16orf96
Class:
LIG_APCC_ABBA_1
Location:
996:1001
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.7772
ASA_SCORE:
67.65
COIL:
0.8563
CONS_SCORE:
0.3664
DSS_SCORE:
0.071
HELIX:
0.0263
FCONS_SCORE:
1.0805
RIG_SCORE:
0.8083
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G1000R
TCGA-AG-A020
READ
TCGA
LYPYGD
LIG_APCC_ABBA_1
0.6457
p.G1000R
DO36451
READ
ICGC
LYPYGD
LIG_APCC_ABBA_1
0.6457
p.T995M
DO230323
COCA
ICGC
LYPYGD
LIG_APCC_ABBA_1
0.3056
p.T995M
ACH-000936
Ovarian Cancer
CCLE
LYPYGD
LIG_APCC_ABBA_1
0.3056
p.P1002S
DO23268
LINC
ICGC
LYPYGD
LIG_APCC_ABBA_1
0.3056
p.V1004M
DO41199
UCEC
ICGC
LYPYGD
LIG_APCC_ABBA_1
0.25
Drug responses associated with C16orf96 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LYPYGD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A6NNT2
Uncharacterized protein C16orf96
LIG_APCC_ABBA_1
996:1001
LYPYGD
APC,CDC20,FZR1
0.7772
More...