DegronMD

Uniprot ID: Q6NSJ2

Source protein: Pleckstrin homology-like domain family B member 3

Source gene: PHLDB3

Class: DEG_SCF_FBW7_1

Location: 80:87

E3 ligase: FBXW7

DEGRON score: 0.826

ASA_SCORE: 86.7625

COIL: 0.9036

CONS_SCORE: 0.516

DSS_SCORE: 0.764

HELIX: 0.0813

FCONS_SCORE: 0.9934

RIG_SCORE: 0.6167

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S90L	TCGA-BF-A5EO	SKCM	TCGA	MAATPPAS	DEG_SCF_FBW7_1	0.25
p.S90L	DO219450	SKCM	ICGC	MAATPPAS	DEG_SCF_FBW7_1	0.25
p.E73D	TCGA-D3-A2JB	SKCM	TCGA	MAATPPAS	DEG_SCF_FBW7_1	0.1389
p.E73D	DO47607	SKCM	ICGC	MAATPPAS	DEG_SCF_FBW7_1	0.1389
p.P77L	DO229326	BTCA	ICGC	MAATPPAS	DEG_SCF_FBW7_1	0.25
p.T83K	DO228974	LICA	ICGC	MAATPPAS	DEG_SCF_FBW7_1	0.8417
p.D70E	DO229006	LICA	ICGC	MAATPPAS	DEG_SCF_FBW7_1	0.0556
p.D70E	DO229008	LICA	ICGC	MAATPPAS	DEG_SCF_FBW7_1	0.0556
p.P72L	DO222546	MELA	ICGC	MAATPPAS	DEG_SCF_FBW7_1	0.1111
p.T75M	DO33091	PACA	ICGC	MAATPPAS	DEG_SCF_FBW7_1	0.1944
p.D70N	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	MAATPPAS	DEG_SCF_FBW7_1	0.0556
p.D70N	H513	pleura	COSMIC	MAATPPAS	DEG_SCF_FBW7_1	0.0556
p.A97V	ACH-000908	Gastric Cancer	CCLE	MAATPPAS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6NSJ2	Pleckstrin homology-like domain family B member 3	DEG_SCF_FBW7_1	80:87	MAATPPAS	FBXW7	0.826	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons