DegronMD

Uniprot ID: Q96RY7

Source protein: Intraflagellar transport protein 140 homolog

Source gene: IFT140

Class: LIG_APCC_ABBA_1

Location: 1:6

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9761

ASA_SCORE: 53.1

COIL: 0.349

CONS_SCORE: 0.426

DSS_SCORE: 0.5902

HELIX: 0.0013

FCONS_SCORE: 1.3724

RIG_SCORE: 0.8358

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q8H	TCGA-CQ-7068	HNSC	TCGA	MALYYD	LIG_APCC_ABBA_1	0.2778
p.Q8H	DO15551	HNSC	ICGC	MALYYD	LIG_APCC_ABBA_1	0.2778
p.A11T	TCGA-DI-A0WH	UCEC	TCGA	MALYYD	LIG_APCC_ABBA_1	0.1944
p.A11T	DO43843	UCEC	ICGC	MALYYD	LIG_APCC_ABBA_1	0.1944
p.M4I	DO472	BLCA	ICGC	MALYYD	LIG_APCC_ABBA_1	0.7618
p.M4I	DO228322	MALY	ICGC	MALYYD	LIG_APCC_ABBA_1	0.7618
p.R3C	DO10647	COAD	ICGC	MALYYD	LIG_APCC_ABBA_1	0.8301
p.R3H	DO8479	COAD	ICGC	MALYYD	LIG_APCC_ABBA_1	0.8244
p.A2V	DO227844	COCA	ICGC	MALYYD	LIG_APCC_ABBA_1	0.5825
p.A2V	ACH-000989	Colon/Colorectal Cancer	CCLE	MALYYD	LIG_APCC_ABBA_1	0.5825
p.A2V	SNU-175	large_intestine	COSMIC	MALYYD	LIG_APCC_ABBA_1	0.5825
p.A2E	DO228976	LICA	ICGC	MALYYD	LIG_APCC_ABBA_1	0.659
p.T8N	DO229028	LICA	ICGC	MALYYD	LIG_APCC_ABBA_1	0.2778
p.L3F	DO222702	MELA	ICGC	MALYYD	LIG_APCC_ABBA_1	0.6981
p.R10Q	DO50127	STAD	ICGC	MALYYD	LIG_APCC_ABBA_1	0.2222
p.V6A	DO229234	THCA	ICGC	MALYYD	LIG_APCC_ABBA_1	0.6936
p.P12R	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	MALYYD	LIG_APCC_ABBA_1	0.1667
p.P12R	ACH-000865	Esophageal Cancer	CCLE	MALYYD	LIG_APCC_ABBA_1	0.1667
p.P12R	KYSE-450	oesophagus	COSMIC	MALYYD	LIG_APCC_ABBA_1	0.1667
p.R3L	ACH-000780	Lung Cancer	CCLE	MALYYD	LIG_APCC_ABBA_1	0.8428
p.R3L	NCI-H1105	lung	COSMIC	MALYYD	LIG_APCC_ABBA_1	0.8428
p.R10W	NCCIT	testis	COSMIC	MALYYD	LIG_APCC_ABBA_1	0.2222
p.R10W	HUH-6-clone5	liver	COSMIC	MALYYD	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96RY7	Intraflagellar transport protein 140 homolog	LIG_APCC_ABBA_1	1:6	MALYYD	APC,CDC20,FZR1	0.9761	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons