DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
MATPAVS
Uniprot ID:
Q7L3V2
Source protein:
Protein Bop
Source gene:
RTL10
Class:
DEG_SCF_FBW7_1
Location:
238:244
E3 ligase:
FBXW7
DEGRON score:
0.8781
ASA_SCORE:
53.7714
COIL:
0.7226
CONS_SCORE:
0.4892
DSS_SCORE:
0.4392
HELIX:
0.252
FCONS_SCORE:
1.0142
RIG_SCORE:
0.675
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A242V
SIDM00217
Colorectal Carcinoma
GDSC
MATPAVS
DEG_SCF_FBW7_1
0.5825
p.A242V
SNU-1040
large_intestine
COSMIC
MATPAVS
DEG_SCF_FBW7_1
0.5825
Drug responses associated with RTL10 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of MATPAVS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q7L3V2
Protein Bop
DEG_SCF_FBW7_1
238:244
MATPAVS
FBXW7
0.8781
More...