DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
MDPTPEAS
Uniprot ID:
Q6ZNG9
Source protein:
KRAB-A domain-containing protein 2
Source gene:
KRBA2
Class:
DEG_SCF_FBW7_1
Location:
471:478
E3 ligase:
FBXW7
DEGRON score:
0.9689
ASA_SCORE:
101.85
COIL:
0.9156
CONS_SCORE:
0.4497
DSS_SCORE:
0.8783
HELIX:
0.057
FCONS_SCORE:
1.1593
RIG_SCORE:
0.6196
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.D466Y
TCGA-DD-AACJ
LIHC
TCGA
MDPTPEAS
DEG_SCF_FBW7_1
0.1944
p.P475L
TCGA-IB-7651
PAAD
TCGA
MDPTPEAS
DEG_SCF_FBW7_1
0.7582
p.P475L
DO46657
PAAD
ICGC
MDPTPEAS
DEG_SCF_FBW7_1
0.7582
Drug responses associated with KRBA2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of MDPTPEAS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q6ZNG9
KRAB-A domain-containing protein 2
DEG_SCF_FBW7_1
471:478
MDPTPEAS
FBXW7
0.9689
More...