DegronMD

Uniprot ID: O94868

Source protein: F-BAR and double SH3 domains protein 2

Source gene: FCHSD2

Class: LIG_APCC_ABBA_1

Location: 453:458

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7833

ASA_SCORE: 75.8667

COIL: 0.6097

CONS_SCORE: 0.3528

DSS_SCORE: 0.6329

HELIX: 0.211

FCONS_SCORE: 0.9877

RIG_SCORE: 0.7591

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E447K	TCGA-19-5956	GBM	TCGA	MDVFDD	LIG_APCC_ABBA_1	0.1667
p.E447K	SIDM00297	Non-Small Cell Lung Carcinoma	GDSC	MDVFDD	LIG_APCC_ABBA_1	0.1667
p.E447K	SIDM01611	Endometrial Carcinoma	GDSC	MDVFDD	LIG_APCC_ABBA_1	0.1667
p.E447K	LC-2-ad	lung	COSMIC	MDVFDD	LIG_APCC_ABBA_1	0.1667
p.D457N	TCGA-A5-A0G2	UCEC	TCGA	MDVFDD	LIG_APCC_ABBA_1	0.5821
p.D457N	TCGA-ER-A19W	SKCM	TCGA	MDVFDD	LIG_APCC_ABBA_1	0.5821
p.R468I	TCGA-AG-A002	READ	TCGA	MDVFDD	LIG_APCC_ABBA_1	0.0556
p.E445D	TCGA-BS-A0UV	UCEC	TCGA	MDVFDD	LIG_APCC_ABBA_1	0.1111
p.P450L	DO225236	BRCA	ICGC	MDVFDD	LIG_APCC_ABBA_1	0.25
p.T457A	DO46657	PAAD	ICGC	MDVFDD	LIG_APCC_ABBA_1	0.7139
p.G446V	SIDM00935	Other Solid Cancers	GDSC	MDVFDD	LIG_APCC_ABBA_1	0.1389
p.G446V	CAL-39	vulva	COSMIC	MDVFDD	LIG_APCC_ABBA_1	0.1389
p.P463R	SIDM00090	Ovarian Carcinoma	GDSC	MDVFDD	LIG_APCC_ABBA_1	0.1944
p.P463R	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	MDVFDD	LIG_APCC_ABBA_1	0.1944
p.P463R	SIDM00903	Non-Small Cell Lung Carcinoma	GDSC	MDVFDD	LIG_APCC_ABBA_1	0.1944
p.P463R	OVCAR-8	ovary	COSMIC	MDVFDD	LIG_APCC_ABBA_1	0.1944
p.P463R	A549	lung	COSMIC	MDVFDD	LIG_APCC_ABBA_1	0.1944
p.T466A	SIDM00333	Endometrial Carcinoma	GDSC	MDVFDD	LIG_APCC_ABBA_1	0.1111
p.T466A	MFE-319	endometrium	COSMIC	MDVFDD	LIG_APCC_ABBA_1	0.1111
p.I458L	ACH-000361	Liver Cancer	CCLE	MDVFDD	LIG_APCC_ABBA_1	0.7174
p.I458L	SK-HEP-1	liver	COSMIC	MDVFDD	LIG_APCC_ABBA_1	0.7174
p.V464M	CW-2	large_intestine	COSMIC	MDVFDD	LIG_APCC_ABBA_1	0.1667
p.G456D	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	MDVFDD	LIG_APCC_ABBA_1	0.7198

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94868	F-BAR and double SH3 domains protein 2	LIG_APCC_ABBA_1	453:458	MDVFDD	APC,CDC20,FZR1	0.7833	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons