DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
MELFEE
Uniprot ID:
Q8NAN2
Source protein:
Mitoguardin 1
Source gene:
MIGA1
Class:
LIG_APCC_ABBA_1
Location:
214:219
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.5252
ASA_SCORE:
50.9167
COIL:
0.0163
CONS_SCORE:
0.5658
DSS_SCORE:
0.1427
HELIX:
0.9823
FCONS_SCORE:
1.3209
RIG_SCORE:
0.9097
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G213S
SIDM02016
Colorectal Carcinoma
GDSC
MELFEE
LIG_APCC_ABBA_1
0.3056
p.E207D
SIDM01611
Endometrial Carcinoma
GDSC
MELFEE
LIG_APCC_ABBA_1
0.1389
Drug responses associated with MIGA1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of MELFEE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NAN2
Mitoguardin 1
LIG_APCC_ABBA_1
214:219
MELFEE
APC,CDC20,FZR1
0.5252
More...