DegronMD

Uniprot ID: P61247

Source protein: 40S ribosomal protein S3a

Source gene: RPS3A

Class: LIG_APCC_ABBA_1

Location: 229:234

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9812

ASA_SCORE: 87.0333

COIL: 0.5552

CONS_SCORE: 0.4205

DSS_SCORE: 0.4646

HELIX: 0.346

FCONS_SCORE: 1.1097

RIG_SCORE: 0.699

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S238F	DO232761	PBCA	ICGC	MELHGE	LIG_APCC_ABBA_1	0.6667
p.V227I	DO232224	PBCA	ICGC	MELHGE	LIG_APCC_ABBA_1	0.7222
p.K240T	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	MELHGE	LIG_APCC_ABBA_1	0.6111
p.K240T	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	MELHGE	LIG_APCC_ABBA_1	0.6111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P61247	40S ribosomal protein S3a	LIG_APCC_ABBA_1	229:234	MELHGE	APC,CDC20,FZR1	0.9812	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons