DegronMD

Uniprot ID: P55895

Source protein: V

Source gene: RAG2

Class: DEG_SCF_FBW7_1

Location: 302:308

E3 ligase: FBXW7

DEGRON score: 0.9767

ASA_SCORE: 76.9571

COIL: 0.9079

CONS_SCORE: 0.812

DSS_SCORE: 0.3866

HELIX: 0.0137

FCONS_SCORE: 1.0993

RIG_SCORE: 0.7865

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N295K	TCGA-67-3771	LUAD	TCGA	METPDWT	DEG_SCF_FBW7_1	0.1389
p.N295K	DO25797	LUAD	ICGC	METPDWT	DEG_SCF_FBW7_1	0.1389
p.D306H	TCGA-AX-A2IO	UCEC	TCGA	METPDWT	DEG_SCF_FBW7_1	0.6577
p.D306H	DO40800	UCEC	ICGC	METPDWT	DEG_SCF_FBW7_1	0.6577
p.F318C	TCGA-BK-A6W3	UCEC	TCGA	METPDWT	DEG_SCF_FBW7_1	0.0556
p.F318C	DO50076	UCEC	ICGC	METPDWT	DEG_SCF_FBW7_1	0.0556
p.E293K	TCGA-D3-A1Q6	SKCM	TCGA	METPDWT	DEG_SCF_FBW7_1	0.0833
p.E293K	TCGA-EE-A29B	SKCM	TCGA	METPDWT	DEG_SCF_FBW7_1	0.0833
p.E293K	DO47255	SKCM	ICGC	METPDWT	DEG_SCF_FBW7_1	0.0833
p.E293K	DO37450	SKCM	ICGC	METPDWT	DEG_SCF_FBW7_1	0.0833
p.E298K	TCGA-D3-A1Q7	SKCM	TCGA	METPDWT	DEG_SCF_FBW7_1	0.2222
p.E298K	DO220859	MELA	ICGC	METPDWT	DEG_SCF_FBW7_1	0.2222
p.E298K	DO37981	SKCM	ICGC	METPDWT	DEG_SCF_FBW7_1	0.2222
p.S314C	TCGA-D3-A5GL	SKCM	TCGA	METPDWT	DEG_SCF_FBW7_1	0.1667
p.S314C	DO47430	SKCM	ICGC	METPDWT	DEG_SCF_FBW7_1	0.1667
p.T308N	DO222608	BTCA	ICGC	METPDWT	DEG_SCF_FBW7_1	0.7055
p.D294E	DO50339	ESAD	ICGC	METPDWT	DEG_SCF_FBW7_1	0.1111
p.E301K	DO50786	LICA	ICGC	METPDWT	DEG_SCF_FBW7_1	0.3056
p.K296N	DO45203	LIRI	ICGC	METPDWT	DEG_SCF_FBW7_1	0.2778
p.R300P	SIDM01129	Small Cell Lung Carcinoma	GDSC	METPDWT	DEG_SCF_FBW7_1	0.2778
p.R300P	ACH-000816	Lung Cancer	CCLE	METPDWT	DEG_SCF_FBW7_1	0.2778
p.R300P	NCI-H524	lung	COSMIC	METPDWT	DEG_SCF_FBW7_1	0.2778
p.D310Y	SIDM01145	Gastric Carcinoma	GDSC	METPDWT	DEG_SCF_FBW7_1	0.2778
p.D310Y	NCI-SNU-16	stomach	COSMIC	METPDWT	DEG_SCF_FBW7_1	0.2778
p.R300H	SIDM01194	Hepatocellular Carcinoma	GDSC	METPDWT	DEG_SCF_FBW7_1	0.2778
p.R300H	SIDM00054	Pancreatic Carcinoma	GDSC	METPDWT	DEG_SCF_FBW7_1	0.2778
p.R300H	SIDM01335	Kidney Carcinoma	GDSC	METPDWT	DEG_SCF_FBW7_1	0.2778
p.K315N	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	METPDWT	DEG_SCF_FBW7_1	0.25
p.K315N	ACH-000875	Lung Cancer	CCLE	METPDWT	DEG_SCF_FBW7_1	0.25
p.K315N	NCI-H2347	lung	COSMIC	METPDWT	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P55895	V	DEG_SCF_FBW7_1	302:308	METPDWT	FBXW7	0.9767	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: METPDWT

Degron related mutations and impact score

Drug responses associated with RAG2 mutations

All proteins holding degron of METPDWT