DegronMD

Uniprot ID: Q96DF8

Source protein: Splicing factor ESS-2 homolog

Source gene: ESS2

Class: DEG_SCF_FBW7_1

Location: 1:7

E3 ligase: FBXW7

DEGRON score: 0.9635

ASA_SCORE: 91.6429

COIL: 0.9546

CONS_SCORE: 0.2592

DSS_SCORE: 0.8708

HELIX: 0.0314

FCONS_SCORE: 0.9035

RIG_SCORE: 0.6527

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S9W	SIDM01006	Plasma Cell Myeloma	GDSC	METPGAS	DEG_SCF_FBW7_1	0.2778
p.S9W	KARPAS-620	haematopoietic_and_lymphoid_tissue	COSMIC	METPGAS	DEG_SCF_FBW7_1	0.2778
p.S7A	SIDM00621	Ewing's Sarcoma	GDSC	METPGAS	DEG_SCF_FBW7_1	0.7588
p.S7A	SIDM00720	Mesothelioma	GDSC	METPGAS	DEG_SCF_FBW7_1	0.7588
p.S7A	SIDM01640	Acute Myeloid Leukemia	GDSC	METPGAS	DEG_SCF_FBW7_1	0.7588

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96DF8	Splicing factor ESS-2 homolog	DEG_SCF_FBW7_1	1:7	METPGAS	FBXW7	0.9635	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons