DegronMD

Uniprot ID: P17480

Source protein: Nucleolar transcription factor 1

Source gene: UBTF

Class: LIG_APCC_ABBA_1

Location: 414:419

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6009

ASA_SCORE: 60.8333

COIL: 0.2317

CONS_SCORE: 0.6124

DSS_SCORE: 0.5523

HELIX: 0.693

FCONS_SCORE: 1.0371

RIG_SCORE: 0.7735

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R422Q	TCGA-A5-A1OF	UCEC	TCGA	MFIFSE	LIG_APCC_ABBA_1	0.25
p.R422Q	DO42568	UCEC	ICGC	MFIFSE	LIG_APCC_ABBA_1	0.25
p.A425V	IM-95	stomach	COSMIC	MFIFSE	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17480	Nucleolar transcription factor 1	LIG_APCC_ABBA_1	414:419	MFIFSE	APC,CDC20,FZR1	0.6009	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons