DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
MGLYPD
Uniprot ID:
Q96JC1
Source protein:
Vam6/Vps39-like protein
Source gene:
VPS39
Class:
LIG_APCC_ABBA_1
Location:
380:385
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8417
ASA_SCORE:
32.8
COIL:
0.478
CONS_SCORE:
0.533
DSS_SCORE:
0.2971
HELIX:
0.5027
FCONS_SCORE:
1.6466
RIG_SCORE:
0.8016
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P373T
TCGA-GN-A26D
SKCM
TCGA
MGLYPD
LIG_APCC_ABBA_1
0.1389
p.P373T
DO37480
SKCM
ICGC
MGLYPD
LIG_APCC_ABBA_1
0.1389
Drug responses associated with VPS39 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of MGLYPD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96JC1
Vam6/Vps39-like protein
LIG_APCC_ABBA_1
380:385
MGLYPD
APC,CDC20,FZR1
0.8417
More...