DegronMD

Uniprot ID: P08887

Source protein: Interleukin-6 receptor subunit alpha

Source gene: IL6R

Class: DEG_SCF_FBW7_2

Location: 311:317

E3 ligase: FBXW7

DEGRON score: 0.5937

ASA_SCORE: 70.0286

COIL: 0.47

CONS_SCORE: 0.5879

DSS_SCORE: 0.6801

HELIX: 0.0091

FCONS_SCORE: 1.0394

RIG_SCORE: 0.6429

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A323S	TCGA-12-1093	GBM	TCGA	MGTPWTE	DEG_SCF_FBW7_2	0.1667
p.A323S	DO14097	GBM	ICGC	MGTPWTE	DEG_SCF_FBW7_2	0.1667
p.A323S	DO229026	LICA	ICGC	MGTPWTE	DEG_SCF_FBW7_2	0.1667
p.E324Q	TCGA-64-1677	LUAD	TCGA	MGTPWTE	DEG_SCF_FBW7_2	0.1389
p.E324Q	DO23996	LUAD	ICGC	MGTPWTE	DEG_SCF_FBW7_2	0.1389
p.T313M	TCGA-DF-A2KU	UCEC	TCGA	MGTPWTE	DEG_SCF_FBW7_2	0.7423
p.T313M	TCGA-FI-A2F4	UCEC	TCGA	MGTPWTE	DEG_SCF_FBW7_2	0.7423
p.T313M	DO43434	UCEC	ICGC	MGTPWTE	DEG_SCF_FBW7_2	0.7423
p.T313M	DO223286	UCEC	ICGC	MGTPWTE	DEG_SCF_FBW7_2	0.7423
p.E326K	TCGA-GC-A3I6	BLCA	TCGA	MGTPWTE	DEG_SCF_FBW7_2	0.0833
p.E326K	DO844	BLCA	ICGC	MGTPWTE	DEG_SCF_FBW7_2	0.0833
p.T316I	SIDM01183	Other Solid Cancers	GDSC	MGTPWTE	DEG_SCF_FBW7_2	0.5966
p.T316I	ACH-001417	Lung Cancer	CCLE	MGTPWTE	DEG_SCF_FBW7_2	0.5966
p.T316I	UMC-11	lung	COSMIC	MGTPWTE	DEG_SCF_FBW7_2	0.5966
p.P308L	SIDM01161	Other Sarcomas	GDSC	MGTPWTE	DEG_SCF_FBW7_2	0.25
p.M311T	SIDM00302	Other Solid Cancers	GDSC	MGTPWTE	DEG_SCF_FBW7_2	0.7423
p.M311T	SIDM00163	Biliary Tract Carcinoma	GDSC	MGTPWTE	DEG_SCF_FBW7_2	0.7423
p.M311T	ACH-000461	Bile Duct Cancer	CCLE	MGTPWTE	DEG_SCF_FBW7_2	0.7423
p.M311T	ACH-002149	Ovarian Cancer	CCLE	MGTPWTE	DEG_SCF_FBW7_2	0.7423
p.M311T	KGN	ovary	COSMIC	MGTPWTE	DEG_SCF_FBW7_2	0.7423
p.E305Q	ACH-001347	Head and Neck Cancer	CCLE	MGTPWTE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P08887	Interleukin-6 receptor subunit alpha	DEG_SCF_FBW7_2	311:317	MGTPWTE	FBXW7	0.5937	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons