DegronMD

Uniprot ID: Q4G1C9

Source protein: GLIPR1-like protein 2

Source gene: GLIPR1L2

Class: DEG_SCF_FBW7_1

Location: 287:294

E3 ligase: FBXW7

DEGRON score: 0.6011

ASA_SCORE: 80.925

COIL: 0.6634

CONS_SCORE: 0.1952

DSS_SCORE: 0.479

HELIX: 0.1431

FCONS_SCORE: 0.9679

RIG_SCORE: 0.7482

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E301D	TCGA-B5-A1MX	UCEC	TCGA	MIFTPEES	DEG_SCF_FBW7_1	0.1389
p.E304D	TCGA-EO-A3AV	UCEC	TCGA	MIFTPEES	DEG_SCF_FBW7_1	0.0556
p.Q277P	SIDM00549	B-Lymphoblastic Leukemia	GDSC	MIFTPEES	DEG_SCF_FBW7_1	0.0556
p.Q277P	ACH-002267	Leukemia	CCLE	MIFTPEES	DEG_SCF_FBW7_1	0.0556
p.Q277P	LC4-1	haematopoietic_and_lymphoid_tissue	COSMIC	MIFTPEES	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4G1C9	GLIPR1-like protein 2	DEG_SCF_FBW7_1	287:294	MIFTPEES	FBXW7	0.6011	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons