DegronMD

Uniprot ID: P07900

Source protein: Heat shock protein HSP 90-alpha

Source gene: HSP90AA1

Class: DEG_APCC_KENBOX_2

Location: 484:488

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7256

ASA_SCORE: 92.02

COIL: 0.7708

CONS_SCORE: 0.626

DSS_SCORE: 0.1922

HELIX: 0.219

FCONS_SCORE: 1.0421

RIG_SCORE: 0.7971

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R477K	TCGA-B5-A3FA	UCEC	TCGA	MKENQ	DEG_APCC_KENBOX_2	0.1389
p.V487I	TCGA-FI-A2D0	UCEC	TCGA	MKENQ	DEG_APCC_KENBOX_2	0.7076
p.C496Y	TCGA-VQ-A8P2	STAD	TCGA	MKENQ	DEG_APCC_KENBOX_2	0.1111
p.R489T	TCGA-ZF-AA4W	BLCA	TCGA	MKENQ	DEG_APCC_KENBOX_2	0.75
p.K485N	DO217864	BTCA	ICGC	MKENQ	DEG_APCC_KENBOX_2	0.6918
p.K485E	DO48676	KIRC	ICGC	MKENQ	DEG_APCC_KENBOX_2	0.7022
p.T495K	DO229026	LICA	ICGC	MKENQ	DEG_APCC_KENBOX_2	0.1389
p.Y480H	DO229213	THCA	ICGC	MKENQ	DEG_APCC_KENBOX_2	0.6667
p.G496C	DO41235	UCEC	ICGC	MKENQ	DEG_APCC_KENBOX_2	0.1111
p.I491T	ACH-000095	Brain Cancer	CCLE	MKENQ	DEG_APCC_KENBOX_2	0.25
p.E497D	ACH-000716	Thyroid Cancer	CCLE	MKENQ	DEG_APCC_KENBOX_2	0.0833
p.E497D	TT2609-C02	thyroid	COSMIC	MKENQ	DEG_APCC_KENBOX_2	0.0833
p.M484I	ACH-001961	Gallbladder Cancer	CCLE	MKENQ	DEG_APCC_KENBOX_2	0.6507
p.D479N	ACH-001961	Gallbladder Cancer	CCLE	MKENQ	DEG_APCC_KENBOX_2	0.1944
p.V475L	ACH-002710	Sarcoma	CCLE	MKENQ	DEG_APCC_KENBOX_2	0.0833
p.H490N	COLO-829	skin	COSMIC	MKENQ	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07900	Heat shock protein HSP 90-alpha	DEG_APCC_KENBOX_2	484:488	MKENQ	APC,CDC20,FZR1	0.7256	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons