DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
MKIHLE
Uniprot ID:
Q9P2H0
Source protein:
Centrosomal protein of 126 kDa
Source gene:
CEP126
Class:
LIG_APCC_ABBA_1
Location:
45:50
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8019
ASA_SCORE:
78.3333
COIL:
0.2542
CONS_SCORE:
0.6178
DSS_SCORE:
0.4251
HELIX:
0.7227
FCONS_SCORE:
1.048
RIG_SCORE:
0.7901
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with CEP126 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of MKIHLE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9P2H0
Centrosomal protein of 126 kDa
LIG_APCC_ABBA_1
45:50
MKIHLE
APC,CDC20,FZR1
0.8019
More...