DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
MKVFCE
Uniprot ID:
Q8NG48
Source protein:
Protein Lines homolog 1
Source gene:
LINS1
Class:
LIG_APCC_ABBA_1
Location:
1:6
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6519
ASA_SCORE:
77.4
COIL:
0.3275
CONS_SCORE:
0.3804
DSS_SCORE:
0.3463
HELIX:
0.6597
FCONS_SCORE:
0.762
RIG_SCORE:
0.9313
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with LINS1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of MKVFCE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NG48
Protein Lines homolog 1
LIG_APCC_ABBA_1
1:6
MKVFCE
APC,CDC20,FZR1
0.6519
More...