DegronMD

Uniprot ID: P27037

Source protein: Activin receptor type-2A

Source gene: ACVR2A

Class: LIG_APCC_ABBA_1

Location: 412:417

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5582

ASA_SCORE: 72.3667

COIL: 0.5802

CONS_SCORE: 0.5503

DSS_SCORE: 0.4024

HELIX: 0.3575

FCONS_SCORE: 1.4765

RIG_SCORE: 0.8101

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M412I	TCGA-37-3792	LUSC	TCGA	MLPFEE	LIG_APCC_ABBA_1	0.6507
p.E418G	TCGA-EO-A22R	UCEC	TCGA	MLPFEE	LIG_APCC_ABBA_1	0.3056
p.P423Q	SIDM00014	Colorectal Carcinoma	GDSC	MLPFEE	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P27037	Activin receptor type-2A	LIG_APCC_ABBA_1	412:417	MLPFEE	APC,CDC20,FZR1	0.5582	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons