DegronMD

Uniprot ID: Q9NX40

Source protein: OCIA domain-containing protein 1

Source gene: OCIAD1

Class: LIG_APCC_ABBA_1

Location: 155:160

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.792

ASA_SCORE: 88.9833

COIL: 0.8827

CONS_SCORE: 0.4507

DSS_SCORE: 0.4854

HELIX: 0.0702

FCONS_SCORE: 0.9236

RIG_SCORE: 0.7621

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M155I	TCGA-EA-A3HS	CESC	TCGA	MLPHYE	LIG_APCC_ABBA_1	0.6507
p.M155I	DO6260	CESC	ICGC	MLPHYE	LIG_APCC_ABBA_1	0.6507
p.A150T	DO233205	GACA	ICGC	MLPHYE	LIG_APCC_ABBA_1	0.1944
p.V145L	DO229036	LICA	ICGC	MLPHYE	LIG_APCC_ABBA_1	0.0556
p.P161S	DO232761	PBCA	ICGC	MLPHYE	LIG_APCC_ABBA_1	0.3056
p.P157L	SIDM00107	Melanoma	GDSC	MLPHYE	LIG_APCC_ABBA_1	0.6471
p.P157L	SIDM01519	Head and Neck Carcinoma	GDSC	MLPHYE	LIG_APCC_ABBA_1	0.6471
p.P157L	ACH-000425	Skin Cancer	CCLE	MLPHYE	LIG_APCC_ABBA_1	0.6471
p.P157L	ACH-000992	Head and Neck Cancer	CCLE	MLPHYE	LIG_APCC_ABBA_1	0.6471
p.P157L	ACH-002004	Skin Cancer	CCLE	MLPHYE	LIG_APCC_ABBA_1	0.6471
p.P157L	UACC-62	skin	COSMIC	MLPHYE	LIG_APCC_ABBA_1	0.6471
p.I153V	SIDM00503	Gastric Carcinoma	GDSC	MLPHYE	LIG_APCC_ABBA_1	0.2778
p.I153V	ACH-000633	Gastric Cancer	CCLE	MLPHYE	LIG_APCC_ABBA_1	0.2778
p.I153V	FU97	stomach	COSMIC	MLPHYE	LIG_APCC_ABBA_1	0.2778
p.M168V	SIDM01578	Bladder Carcinoma	GDSC	MLPHYE	LIG_APCC_ABBA_1	0.1111
p.M168V	ACH-000862	Bladder Cancer	CCLE	MLPHYE	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NX40	OCIA domain-containing protein 1	LIG_APCC_ABBA_1	155:160	MLPHYE	APC,CDC20,FZR1	0.792	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons