DegronMD

Uniprot ID: Q96RY5

Source protein: Protein cramped-like

Source gene: CRAMP1

Class: DEG_SCF_FBW7_1

Location: 1178:1185

E3 ligase: FBXW7

DEGRON score: 0.9683

ASA_SCORE: 82.625

COIL: 0.926

CONS_SCORE: 0.3633

DSS_SCORE: 0.5574

HELIX: 0.02

FCONS_SCORE: 0.9466

RIG_SCORE: 0.6795

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1194L	SIDM00477	Esophageal Carcinoma	GDSC	MLPTPIGT	DEG_SCF_FBW7_1	0.0833
p.P1194L	OE33	oesophagus	COSMIC	MLPTPIGT	DEG_SCF_FBW7_1	0.0833
p.M1178I	SIDM00443	B-Cell Non-Hodgkin's Lymphoma	GDSC	MLPTPIGT	DEG_SCF_FBW7_1	0.6507
p.M1178I	NU-DUL-1	haematopoietic_and_lymphoid_tissue	COSMIC	MLPTPIGT	DEG_SCF_FBW7_1	0.6507

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96RY5	Protein cramped-like	DEG_SCF_FBW7_1	1178:1185	MLPTPIGT	FBXW7	0.9683	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons