DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
MLR
Uniprot ID:
O75636
Source protein:
Ficolin-3
Source gene:
FCN3
Class:
DEG_APCC_TPR_1
Location:
297:299
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.7172
ASA_SCORE:
137.6667
COIL:
0.9813
CONS_SCORE:
0.8752
DSS_SCORE:
0.764
HELIX:
0.0033
FCONS_SCORE:
1.09
RIG_SCORE:
0.8118
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R299Q
TCGA-AP-A0LM
UCEC
TCGA
MLR
DEG_APCC_TPR_1
0.7329
p.R292H
SIDM00499
Prostate Carcinoma
GDSC
MLR
DEG_APCC_TPR_1
0.1944
p.R292H
22RV1
prostate
COSMIC
MLR
DEG_APCC_TPR_1
0.1944
p.R288Q
DO43306
UCEC
ICGC
MLR
DEG_APCC_TPR_1
0.0833
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Drug responses associated with FCN3 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of MLR
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O75636
Ficolin-3
DEG_APCC_TPR_1
297:299
MLR
APC,CDC20,FZR1
0.7172
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