DegronMD

Uniprot ID: O75636

Source protein: Ficolin-3

Source gene: FCN3

Class: DEG_APCC_TPR_1

Location: 297:299

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7172

ASA_SCORE: 137.6667

COIL: 0.9813

CONS_SCORE: 0.8752

DSS_SCORE: 0.764

HELIX: 0.0033

FCONS_SCORE: 1.09

RIG_SCORE: 0.8118

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R299Q	TCGA-AP-A0LM	UCEC	TCGA	MLR	DEG_APCC_TPR_1	0.7329
p.R288Q	DO43306	UCEC	ICGC	MLR	DEG_APCC_TPR_1	0.0833
p.R292H	SIDM00499	Prostate Carcinoma	GDSC	MLR	DEG_APCC_TPR_1	0.1944
p.R292H	22RV1	prostate	COSMIC	MLR	DEG_APCC_TPR_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75636	Ficolin-3	DEG_APCC_TPR_1	297:299	MLR	APC,CDC20,FZR1	0.7172	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons