DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
MLTTPNHT
Uniprot ID:
Q9BTC8
Source protein:
Metastasis-associated protein MTA3
Source gene:
MTA3
Class:
DEG_SCF_FBW7_1
Location:
562:569
E3 ligase:
FBXW7
DEGRON score:
0.9964
ASA_SCORE:
84.775
COIL:
0.9204
CONS_SCORE:
0.4295
DSS_SCORE:
0.549
HELIX:
0.0331
FCONS_SCORE:
1.1695
RIG_SCORE:
0.7184
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R561W
SIDM01307
Colorectal Carcinoma
GDSC
MLTTPNHT
DEG_SCF_FBW7_1
0.3056
p.T558I
ACH-000753
Bladder Cancer
CCLE
MLTTPNHT
DEG_SCF_FBW7_1
0.2222
Drug responses associated with MTA3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of MLTTPNHT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9BTC8
Metastasis-associated protein MTA3
DEG_SCF_FBW7_1
562:569
MLTTPNHT
FBXW7
0.9964
More...