DegronMD

Uniprot ID: Q99592

Source protein: Zinc finger and BTB domain-containing protein 18

Source gene: ZBTB18

Class: DEG_SCF_FBW7_2

Location: 337:343

E3 ligase: FBXW7

DEGRON score: 0.6861

ASA_SCORE: 104.4714

COIL: 0.7994

CONS_SCORE: 0.5368

DSS_SCORE: 0.6921

HELIX: 0.152

FCONS_SCORE: 0.9815

RIG_SCORE: 0.6948

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R337W	TCGA-33-4533	LUSC	TCGA	MMTPESE	DEG_SCF_FBW7_2	0.8634
p.R337W	DO27572	LUSC	ICGC	MMTPESE	DEG_SCF_FBW7_2	0.8634
p.D329Y	TCGA-B6-A0IB	BRCA	TCGA	MMTPESE	DEG_SCF_FBW7_2	0.1111
p.D329Y	DO5689	BRCA	ICGC	MMTPESE	DEG_SCF_FBW7_2	0.1111
p.R353C	TCGA-HU-8602	STAD	TCGA	MMTPESE	DEG_SCF_FBW7_2	0.0556
p.R353C	DO47829	STAD	ICGC	MMTPESE	DEG_SCF_FBW7_2	0.0556
p.M346I	DO225013	BRCA	ICGC	MMTPESE	DEG_SCF_FBW7_2	0.25
p.M346I	DO52557	BRCA	ICGC	MMTPESE	DEG_SCF_FBW7_2	0.25
p.R353H	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	MMTPESE	DEG_SCF_FBW7_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99592	Zinc finger and BTB domain-containing protein 18	DEG_SCF_FBW7_2	337:343	MMTPESE	FBXW7	0.6861	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons