DegronMD

Uniprot ID: Q13315

Source protein: Serine-protein kinase ATM

Source gene: ATM

Class: LIG_APCC_ABBA_1

Location: 855:860

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8801

ASA_SCORE: 83.6

COIL: 0.6553

CONS_SCORE: 0.2765

DSS_SCORE: 0.6178

HELIX: 0.2802

FCONS_SCORE: 1.0648

RIG_SCORE: 0.7028

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D868G	TCGA-AX-A1C9	UCEC	TCGA	MNLFND	LIG_APCC_ABBA_1	0.1111
p.D868G	DO43098	UCEC	ICGC	MNLFND	LIG_APCC_ABBA_1	0.1111
p.D863G	TCGA-BG-A222	UCEC	TCGA	MNLFND	LIG_APCC_ABBA_1	0.25
p.D863G	DO42977	UCEC	ICGC	MNLFND	LIG_APCC_ABBA_1	0.25
p.S867T	TCGA-CC-A3MB	LIHC	TCGA	MNLFND	LIG_APCC_ABBA_1	0.1389
p.S867T	DO23068	LIHC	ICGC	MNLFND	LIG_APCC_ABBA_1	0.1389
p.D863N	TCGA-XF-AAML	BLCA	TCGA	MNLFND	LIG_APCC_ABBA_1	0.25
p.D863N	DO51933	BLCA	ICGC	MNLFND	LIG_APCC_ABBA_1	0.25
p.A869V	DO230342	COCA	ICGC	MNLFND	LIG_APCC_ABBA_1	0.0833
p.E848D	DO223045	ESCA	ICGC	MNLFND	LIG_APCC_ABBA_1	0.1389
p.F858S	DO225438	LAML	ICGC	MNLFND	LIG_APCC_ABBA_1	0.7982
p.E850D	DO228948	LICA	ICGC	MNLFND	LIG_APCC_ABBA_1	0.1944
p.D860N	DO227684	PACA	ICGC	MNLFND	LIG_APCC_ABBA_1	0.6932
p.E848Q	SIDM00708	Non-Small Cell Lung Carcinoma	GDSC	MNLFND	LIG_APCC_ABBA_1	0.1389
p.E848Q	ACH-000841	Lung Cancer	CCLE	MNLFND	LIG_APCC_ABBA_1	0.1389
p.E848Q	NCI-H2087	lung	COSMIC	MNLFND	LIG_APCC_ABBA_1	0.1389
p.L857V	SIDM01569	Hepatocellular Carcinoma	GDSC	MNLFND	LIG_APCC_ABBA_1	0.5654
p.L857V	ACH-000734	Liver Cancer	CCLE	MNLFND	LIG_APCC_ABBA_1	0.5654

Drug responses associated with ATM mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00544	NB\|neuroblastoma	p.K31* (No)	GDSC	CP466722	23.2612
SIDM00544	NB\|neuroblastoma	p.K31* (No)	GDSC	KU-55933	16.9614
SIDM00544	NB\|neuroblastoma	p.K31* (No)	GDSC	KU-60019	15.4605
SIDM01045	UCEC\|endometrium	p.S2812fs*3 (No)	GDSC	CP466722	13.7861
SIDM01045	UCEC\|endometrium	p.S2812fs*3 (No)	GDSC	KU-55933	94.2462
SIDM01045	UCEC\|endometrium	p.S2812fs*3 (No)	GDSC	KU-60019	53.6084
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.K2811fs*46 (No)	GDSC	CP466722	9.0132
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.K2811fs*46 (No)	GDSC	KU-55933	17.1557
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.K2811fs*46 (No)	GDSC	KU-60019	7.1064
SIDM00683	PRAD\|prostate	p.Q912* (No)	GDSC	CP466722	6.4684
SIDM00683	PRAD\|prostate	p.Q912* (No)	GDSC	KU-55933	172.1495
SIDM00683	PRAD\|prostate	p.Q912* (No)	GDSC	KU-60019	18.9435
SIDM00997	THCA\|thyroid	p.Q2800* (No)	GDSC	CP466722	39.0117
SIDM00997	THCA\|thyroid	p.Q2800* (No)	GDSC	KU-55933	17.2674
SIDM00997	THCA\|thyroid	p.Q2800* (No)	GDSC	KU-60019	7.2544
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.K2811fs*46 (No)	GDSC	CP466722	5.8645
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.K2811fs*46 (No)	GDSC	KU-55933	9.8274
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.K2811fs*46 (No)	GDSC	KU-60019	5.5191
SIDM00251	STAD\|stomach	p.R23* (No)	GDSC	CP466722	24.1381
SIDM00251	STAD\|stomach	p.R23* (No)	GDSC	KU-55933	28.1082
SIDM00251	STAD\|stomach	p.R23* (No)	GDSC	KU-60019	33.9976
SIDM00220	OV\|ovary	p.R1618* (No)	GDSC	CP466722	5.4233
SIDM00220	OV\|ovary	p.R1618* (No)	GDSC	KU-55933	41.5991
SIDM00220	OV\|ovary	p.R1618* (No)	GDSC	KU-60019	9.9442
SIDM00498	COREAD\|large_intestine	p.Y2167* (No)	GDSC	CP466722	50.1237
SIDM00498	COREAD\|large_intestine	p.Y2167* (No)	GDSC	KU-55933	18.5202
SIDM00498	COREAD\|large_intestine	p.Y2167* (No)	GDSC	KU-60019	55.1873
SIDM01043	UNCLASSIFIED\|endometrium	p.R2849* (No)	GDSC	CP466722	10.9933
SIDM01043	UNCLASSIFIED\|endometrium	p.R2849* (No)	GDSC	KU-55933	29.616
SIDM01043	UNCLASSIFIED\|endometrium	p.R2849* (No)	GDSC	KU-60019	25.1955
SIDM01129	SCLC\|lung_small_cell_carcinoma	p.R337C (No)	GDSC	CP466722	14.3038
SIDM01129	SCLC\|lung_small_cell_carcinoma	p.R337C (No)	GDSC	KU-55933	53.7725
SIDM01129	SCLC\|lung_small_cell_carcinoma	p.R337C (No)	GDSC	KU-60019	30.9149
SIDM00769	LUAD\|lung_NSCLC_adenocarcinoma	p.W1279* (No)	GDSC	CP466722	69.9814
SIDM00769	LUAD\|lung_NSCLC_adenocarcinoma	p.W1279* (No)	GDSC	KU-55933	9.93
SIDM00769	LUAD\|lung_NSCLC_adenocarcinoma	p.W1279* (No)	GDSC	KU-60019	59.0591
SIDM01088	UNCLASSIFIED\|endometrium	p.K1773fs*3 (No)	GDSC	CP466722	25.4863
SIDM01088	UNCLASSIFIED\|endometrium	p.K1773fs*3 (No)	GDSC	KU-55933	72.7775
SIDM00879	BRCA\|breast	p.W2638* (No)	GDSC	CP466722	2.2643
SIDM00879	BRCA\|breast	p.W2638* (No)	GDSC	KU-55933	55.5164
SIDM00879	BRCA\|breast	p.W2638* (No)	GDSC	KU-60019	29.299
SIDM00879	BRCA\|breast	p.W2638* (No)	GDSC	KU-55933	146.03
SIDM00695	SKCM\|melanoma	p.W2845* (No)	GDSC	CP466722	8.2488
SIDM00695	SKCM\|melanoma	p.W2845* (No)	GDSC	KU-55933	65.0541
SIDM00695	SKCM\|melanoma	p.W2845* (No)	GDSC	KU-60019	16.099
SIDM00832	COREAD\|large_intestine	p.Q2210* (No)	GDSC	CP466722	53.8256
SIDM00832	COREAD\|large_intestine	p.Q2210* (No)	GDSC	KU-55933	360.9152
SIDM00832	COREAD\|large_intestine	p.Q2210* (No)	GDSC	KU-60019	234.6561
SIDM01146	STAD\|stomach	p.L1154fs*12 (No)	GDSC	CP466722	5.8956
SIDM01146	STAD\|stomach	p.L1154fs*12 (No)	GDSC	KU-55933	20.4001
SIDM01146	STAD\|stomach	p.L1154fs*12 (No)	GDSC	KU-60019	184.232
SIDM01106	SKCM\|melanoma	p.I1290fs*6 (No)	GDSC	CP466722	19.0681
SIDM01106	SKCM\|melanoma	p.I1290fs*6 (No)	GDSC	KU-55933	72.532
SIDM01106	SKCM\|melanoma	p.I1290fs*6 (No)	GDSC	KU-60019	22.3889
SIDM00282	COREAD\|large_intestine	p.Q628fs*7 (No)	GDSC	CP466722	83.8915
SIDM00282	COREAD\|large_intestine	p.Q628fs*7 (No)	GDSC	KU-55933	171.1443
SIDM00282	COREAD\|large_intestine	p.Q628fs*7 (No)	GDSC	KU-60019	12.7693
SIDM00282	COREAD\|large_intestine	p.I1581fs*5 (No)	GDSC	CP466722	83.8915
SIDM00282	COREAD\|large_intestine	p.I1581fs*5 (No)	GDSC	KU-55933	171.1443
SIDM00282	COREAD\|large_intestine	p.I1581fs*5 (No)	GDSC	KU-60019	12.7693
SIDM01182	BLCA\|bladder	p.Q2800fs*6 (No)	GDSC	CP466722	4.9488
SIDM01182	BLCA\|bladder	p.Q2800fs*6 (No)	GDSC	KU-55933	17.95
SIDM01182	BLCA\|bladder	p.Q2800fs*6 (No)	GDSC	KU-60019	13.0518
SIDM00679	CESC\|cervix	p.P1069fs*2 (No)	GDSC	CP466722	21.4798
SIDM00679	CESC\|cervix	p.P1069fs*2 (No)	GDSC	KU-55933	73.4611
SIDM00679	CESC\|cervix	p.P1069fs*2 (No)	GDSC	KU-60019	29.1927
SIDM00118	COREAD\|large_intestine	p.R250* (No)	GDSC	CP466722	13.3514
SIDM00118	COREAD\|large_intestine	p.R250* (No)	GDSC	KU-55933	95.2793
SIDM00118	COREAD\|large_intestine	p.R250* (No)	GDSC	KU-60019	50.0573
SIDM00118	COREAD\|large_intestine	p.E277* (No)	GDSC	CP466722	13.3514
SIDM00118	COREAD\|large_intestine	p.E277* (No)	GDSC	KU-55933	95.2793
SIDM00118	COREAD\|large_intestine	p.E277* (No)	GDSC	KU-60019	50.0573
SIDM00118	COREAD\|large_intestine	p.R337C (No)	GDSC	CP466722	13.3514
SIDM00118	COREAD\|large_intestine	p.R337C (No)	GDSC	KU-55933	95.2793
SIDM00118	COREAD\|large_intestine	p.R337C (No)	GDSC	KU-60019	50.0573
SIDM00926	UNCLASSIFIED\|lung_NSCLC_not_specified	p.M1210V (No)	GDSC	CP466722	60.275
SIDM00926	UNCLASSIFIED\|lung_NSCLC_not_specified	p.M1210V (No)	GDSC	KU-55933	156.1145
SIDM00926	UNCLASSIFIED\|lung_NSCLC_not_specified	p.M1210V (No)	GDSC	KU-60019	50.9491
SIDM00554	UNCLASSIFIED\|ovary	p.M1644T (No)	GDSC	CP466722	20.2707
SIDM00554	UNCLASSIFIED\|ovary	p.M1644T (No)	GDSC	KU-55933	65.3306
SIDM00554	UNCLASSIFIED\|ovary	p.M1644T (No)	GDSC	KU-60019	48.5616
SIDM00554	UNCLASSIFIED\|ovary	p.I2223M (No)	GDSC	CP466722	20.2707
SIDM00554	UNCLASSIFIED\|ovary	p.I2223M (No)	GDSC	KU-55933	65.3306
SIDM00554	UNCLASSIFIED\|ovary	p.I2223M (No)	GDSC	KU-60019	48.5616
SIDM00720	MESO\|mesothelioma	p.Q1361R (No)	GDSC	CP466722	65.4014
SIDM00720	MESO\|mesothelioma	p.Q1361R (No)	GDSC	KU-55933	46.3742
SIDM00720	MESO\|mesothelioma	p.Q1361R (No)	GDSC	KU-60019	5.8757
SIDM00223	SCLC\|lung_small_cell_carcinoma	p.A2688V (No)	GDSC	CP466722	5.2053
SIDM00223	SCLC\|lung_small_cell_carcinoma	p.A2688V (No)	GDSC	KU-55933	91.9469
SIDM00223	SCLC\|lung_small_cell_carcinoma	p.A2688V (No)	GDSC	KU-60019	35.5311
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.A1090T (No)	GDSC	CP466722	6.8527
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.A1090T (No)	GDSC	KU-55933	9.9166
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.A1090T (No)	GDSC	KU-60019	4.1492
SIDM00961	UNCLASSIFIED\|ewings_sarcoma	p.H1380Y (No)	GDSC	CP466722	1.9209
SIDM00961	UNCLASSIFIED\|ewings_sarcoma	p.H1380Y (No)	GDSC	KU-55933	32.3541
SIDM00961	UNCLASSIFIED\|ewings_sarcoma	p.H1380Y (No)	GDSC	KU-60019	70.5627
SIDM00345	UNCLASSIFIED\|lung_NSCLC_large_cell	p.N2826I (No)	GDSC	CP466722	8.8299
SIDM00345	UNCLASSIFIED\|lung_NSCLC_large_cell	p.N2826I (No)	GDSC	KU-55933	27.243
SIDM00345	UNCLASSIFIED\|lung_NSCLC_large_cell	p.N2826I (No)	GDSC	KU-60019	12.0711
SIDM00578	NB\|neuroblastoma	p.H1380Y (No)	GDSC	KU-55933	103.75
SIDM00578	NB\|neuroblastoma	p.H1380Y (No)	GDSC	KU-60019	76.886
SIDM00325	ESCA\|oesophagus	p.Q1128E (No)	GDSC	CP466722	74.4917
SIDM00325	ESCA\|oesophagus	p.Q1128E (No)	GDSC	KU-55933	74.2283
SIDM00325	ESCA\|oesophagus	p.Q1128E (No)	GDSC	KU-60019	12.3636
SIDM01031	ESCA\|oesophagus	p.A2635G (No)	GDSC	CP466722	20.3939
SIDM01031	ESCA\|oesophagus	p.A2635G (No)	GDSC	KU-55933	79.4025
SIDM01031	ESCA\|oesophagus	p.A2635G (No)	GDSC	KU-60019	19.8713
SIDM00778	COREAD\|large_intestine	p.Q2733P (No)	GDSC	CP466722	5.0025
SIDM00778	COREAD\|large_intestine	p.Q2733P (No)	GDSC	KU-55933	166.2685
SIDM00778	COREAD\|large_intestine	p.Q2733P (No)	GDSC	KU-60019	33.7853
SIDM00358	STAD\|stomach	p.H1380Y (No)	GDSC	CP466722	16.9957
SIDM00358	STAD\|stomach	p.H1380Y (No)	GDSC	KU-55933	153.4336
SIDM00358	STAD\|stomach	p.H1380Y (No)	GDSC	KU-60019	16.1755
SIDM00210	UNCLASSIFIED\|ovary	p.P604S (No)	GDSC	CP466722	3.9807
SIDM00210	UNCLASSIFIED\|ovary	p.P604S (No)	GDSC	KU-55933	104.4965
SIDM00210	UNCLASSIFIED\|ovary	p.P604S (No)	GDSC	KU-60019	11.2223
SIDM00688	DLBC\|B_cell_lymphoma	p.V551L (No)	GDSC	CP466722	2.6915
SIDM00688	DLBC\|B_cell_lymphoma	p.V551L (No)	GDSC	KU-55933	50.593
SIDM00688	DLBC\|B_cell_lymphoma	p.V551L (No)	GDSC	KU-60019	14.0401
SIDM00315	GBM\|glioma	p.H1380Y (No)	GDSC	CP466722	12.3224
SIDM00315	GBM\|glioma	p.H1380Y (No)	GDSC	KU-55933	26.3745
SIDM00315	GBM\|glioma	p.H1380Y (No)	GDSC	KU-60019	18.662
SIDM01135	PAAD\|pancreas	p.S49C (No)	GDSC	CP466722	6.9892
SIDM01135	PAAD\|pancreas	p.S49C (No)	GDSC	KU-55933	119.6564
SIDM01135	PAAD\|pancreas	p.S49C (No)	GDSC	KU-60019	31.8619
SIDM00929	UNCLASSIFIED\|chondrosarcoma	p.H1380Y (No)	GDSC	CP466722	143.7273
SIDM00929	UNCLASSIFIED\|chondrosarcoma	p.H1380Y (No)	GDSC	KU-55933	119.9762
SIDM00929	UNCLASSIFIED\|chondrosarcoma	p.H1380Y (No)	GDSC	KU-60019	42.532
SIDM00929	UNCLASSIFIED\|chondrosarcoma	p.R1618Q (No)	GDSC	CP466722	143.7273
SIDM00929	UNCLASSIFIED\|chondrosarcoma	p.R1618Q (No)	GDSC	KU-55933	119.9762
SIDM00929	UNCLASSIFIED\|chondrosarcoma	p.R1618Q (No)	GDSC	KU-60019	42.532
SIDM00151	OV\|ovary	p.R248Q (No)	GDSC	KU-55933	66.8037
SIDM00151	OV\|ovary	p.R248Q (No)	GDSC	KU-60019	12.2831
SIDM00499	PRAD\|prostate	p.K1101E (No)	GDSC	CP466722	8.5812
SIDM00499	PRAD\|prostate	p.K1101E (No)	GDSC	KU-55933	140.9066
SIDM00499	PRAD\|prostate	p.K1101E (No)	GDSC	KU-60019	88.945
SIDM00145	ALL\|lymphoblastic_leukemia	p.R32C (No)	GDSC	CP466722	2.2341
SIDM00145	ALL\|lymphoblastic_leukemia	p.R32C (No)	GDSC	KU-55933	16.8169
SIDM00145	ALL\|lymphoblastic_leukemia	p.R32C (No)	GDSC	KU-60019	13.2298
SIDM00145	ALL\|lymphoblastic_leukemia	p.S2165F (No)	GDSC	CP466722	2.2341
SIDM00145	ALL\|lymphoblastic_leukemia	p.S2165F (No)	GDSC	KU-55933	16.8169
SIDM00145	ALL\|lymphoblastic_leukemia	p.S2165F (No)	GDSC	KU-60019	13.2298
SIDM00348	ESCA\|oesophagus	p.L944V (No)	GDSC	CP466722	36.3101
SIDM00348	ESCA\|oesophagus	p.L944V (No)	GDSC	KU-55933	20.8972
SIDM00348	ESCA\|oesophagus	p.L944V (No)	GDSC	KU-60019	16.2533
SIDM00023	ESCA\|oesophagus	p.H1380Y (No)	GDSC	CP466722	3.4092
SIDM00023	ESCA\|oesophagus	p.H1380Y (No)	GDSC	KU-55933	73.512
SIDM00023	ESCA\|oesophagus	p.H1380Y (No)	GDSC	KU-60019	19.7672
SIDM01187	BRCA\|breast	p.P604S (No)	GDSC	CP466722	5.9219
SIDM01187	BRCA\|breast	p.R832C (No)	GDSC	CP466722	5.9219
SIDM00272	BRCA\|breast	p.E1856Q (No)	GDSC	CP466722	9.4173
SIDM00272	BRCA\|breast	p.E1856Q (No)	GDSC	KU-55933	96.8635
SIDM00272	BRCA\|breast	p.E1856Q (No)	GDSC	KU-60019	38.0495
SIDM00272	BRCA\|breast	p.E1856Q (No)	GDSC	KU-55933	131.92
SIDM00831	HNSC\|head_and_neck	p.S49C (No)	GDSC	CP466722	35.7322
SIDM00831	HNSC\|head_and_neck	p.S49C (No)	GDSC	KU-55933	63.7701
SIDM00831	HNSC\|head_and_neck	p.S49C (No)	GDSC	KU-60019	8.4487
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.G514D (No)	GDSC	CP466722	4.0878
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.G514D (No)	GDSC	KU-55933	63.2936
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.G514D (No)	GDSC	KU-60019	25.9304
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.H1380Y (No)	GDSC	CP466722	4.0878
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.H1380Y (No)	GDSC	KU-55933	63.2936
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.H1380Y (No)	GDSC	KU-60019	25.9304
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.Q1919P (No)	GDSC	CP466722	4.0878
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.Q1919P (No)	GDSC	KU-55933	63.2936
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.Q1919P (No)	GDSC	KU-60019	25.9304
SIDM00785	LAML\|acute_myeloid_leukaemia	p.L546V (No)	GDSC	CP466722	2.8989
SIDM00785	LAML\|acute_myeloid_leukaemia	p.L546V (No)	GDSC	KU-55933	20.1208
SIDM00785	LAML\|acute_myeloid_leukaemia	p.L546V (No)	GDSC	KU-60019	29.6788
SIDM00785	LAML\|acute_myeloid_leukaemia	p.P872S (No)	GDSC	CP466722	2.8989
SIDM00785	LAML\|acute_myeloid_leukaemia	p.P872S (No)	GDSC	KU-55933	20.1208
SIDM00785	LAML\|acute_myeloid_leukaemia	p.P872S (No)	GDSC	KU-60019	29.6788
SIDM00785	LAML\|acute_myeloid_leukaemia	p.L2332P (No)	GDSC	CP466722	2.8989
SIDM00785	LAML\|acute_myeloid_leukaemia	p.L2332P (No)	GDSC	KU-55933	20.1208
SIDM00785	LAML\|acute_myeloid_leukaemia	p.L2332P (No)	GDSC	KU-60019	29.6788
SIDM00617	LIHC\|liver	p.P960R (No)	GDSC	CP466722	12.0808
SIDM00617	LIHC\|liver	p.P960R (No)	GDSC	KU-55933	35.8281
SIDM00617	LIHC\|liver	p.P960R (No)	GDSC	KU-60019	19.0567
SIDM00956	ESCA\|oesophagus	p.H683R (No)	GDSC	CP466722	20.9057
SIDM00956	ESCA\|oesophagus	p.H683R (No)	GDSC	KU-55933	95.8907
SIDM00956	ESCA\|oesophagus	p.H683R (No)	GDSC	KU-60019	9.215
SIDM00045	STAD\|stomach	p.V2166A (No)	GDSC	CP466722	9.2212
SIDM00045	STAD\|stomach	p.V2166A (No)	GDSC	KU-55933	9.4587
SIDM00045	STAD\|stomach	p.V2166A (No)	GDSC	KU-60019	10.6026
SIDM00527	COREAD\|large_intestine	p.S49C (No)	GDSC	CP466722	90.3747
SIDM00527	COREAD\|large_intestine	p.S49C (No)	GDSC	KU-55933	67.7561
SIDM00527	COREAD\|large_intestine	p.S49C (No)	GDSC	KU-60019	18.2043
SIDM00519	MESO\|mesothelioma	p.S2058L (No)	GDSC	CP466722	7.1007
SIDM00519	MESO\|mesothelioma	p.S2058L (No)	GDSC	KU-55933	307.7319
SIDM00519	MESO\|mesothelioma	p.S2058L (No)	GDSC	KU-60019	45.5154
SIDM00566	HNSC\|head_and_neck	p.S2218N (No)	GDSC	CP466722	22.5379
SIDM00566	HNSC\|head_and_neck	p.S2218N (No)	GDSC	KU-55933	22.6375
SIDM00566	HNSC\|head_and_neck	p.S2218N (No)	GDSC	KU-60019	12.6094
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.T2335I (No)	GDSC	CP466722	15.335
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.T2335I (No)	GDSC	KU-55933	21.2999
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.T2335I (No)	GDSC	KU-60019	50.3738
SIDM01007	ALL\|lymphoblastic_leukemia	p.L787F (No)	GDSC	CP466722	0.7925
SIDM01007	ALL\|lymphoblastic_leukemia	p.L787F (No)	GDSC	KU-55933	6.5348
SIDM01007	ALL\|lymphoblastic_leukemia	p.L787F (No)	GDSC	KU-60019	7.198
SIDM01007	ALL\|lymphoblastic_leukemia	p.N1784S (No)	GDSC	CP466722	0.7925
SIDM01007	ALL\|lymphoblastic_leukemia	p.N1784S (No)	GDSC	KU-55933	6.5348
SIDM01007	ALL\|lymphoblastic_leukemia	p.N1784S (No)	GDSC	KU-60019	7.198
SIDM01007	ALL\|lymphoblastic_leukemia	p.L1809P (No)	GDSC	CP466722	0.7925
SIDM01007	ALL\|lymphoblastic_leukemia	p.L1809P (No)	GDSC	KU-55933	6.5348
SIDM01007	ALL\|lymphoblastic_leukemia	p.L1809P (No)	GDSC	KU-60019	7.198
SIDM00098	MESO\|mesothelioma	p.S49C (No)	GDSC	CP466722	11.1717
SIDM00098	MESO\|mesothelioma	p.S49C (No)	GDSC	KU-55933	41.3179
SIDM00098	MESO\|mesothelioma	p.S49C (No)	GDSC	KU-60019	17.0702
SIDM00781	COREAD\|large_intestine	p.S974F (No)	GDSC	CP466722	29.3367
SIDM00781	COREAD\|large_intestine	p.S974F (No)	GDSC	KU-55933	226.8119
SIDM00781	COREAD\|large_intestine	p.S974F (No)	GDSC	KU-60019	45.7816
SIDM00781	COREAD\|large_intestine	p.F1236Y (No)	GDSC	CP466722	29.3367
SIDM00781	COREAD\|large_intestine	p.F1236Y (No)	GDSC	KU-55933	226.8119
SIDM00781	COREAD\|large_intestine	p.F1236Y (No)	GDSC	KU-60019	45.7816
SIDM00146	BRCA\|breast	p.N1005I (No)	GDSC	CP466722	8.8939
SIDM00146	BRCA\|breast	p.N1005I (No)	GDSC	KU-55933	109.5715
SIDM00146	BRCA\|breast	p.N1005I (No)	GDSC	KU-60019	7.4566
SIDM00146	BRCA\|breast	p.N1005I (No)	GDSC	KU-55933	65.31
SIDM00943	PAAD\|pancreas	p.T2640I (No)	GDSC	CP466722	50.7295
SIDM00943	PAAD\|pancreas	p.T2640I (No)	GDSC	KU-55933	120.099
SIDM00943	PAAD\|pancreas	p.T2640I (No)	GDSC	KU-60019	210.7937
SIDM00466	OV\|ovary	p.T935R (No)	GDSC	CP466722	34.2482
SIDM00466	OV\|ovary	p.T935R (No)	GDSC	KU-55933	594.3349
SIDM00466	OV\|ovary	p.T935R (No)	GDSC	KU-60019	95.1468
SIDM00466	OV\|ovary	p.H1380Y (No)	GDSC	CP466722	34.2482
SIDM00466	OV\|ovary	p.H1380Y (No)	GDSC	KU-55933	594.3349
SIDM00466	OV\|ovary	p.H1380Y (No)	GDSC	KU-60019	95.1468
SIDM01058	DLBC\|B_cell_lymphoma	p.R2832C (No)	GDSC	CP466722	5.5195
SIDM01058	DLBC\|B_cell_lymphoma	p.R2832C (No)	GDSC	KU-55933	37.2853
SIDM01058	DLBC\|B_cell_lymphoma	p.R2832C (No)	GDSC	KU-60019	30.7493
SIDM01132	MB\|medulloblastoma	p.S707P (No)	GDSC	CP466722	6.7926
SIDM01132	MB\|medulloblastoma	p.S707P (No)	GDSC	KU-55933	49.3756
SIDM01132	MB\|medulloblastoma	p.S707P (No)	GDSC	KU-60019	44.9883
SIDM00251	STAD\|stomach	p.T935R (No)	GDSC	CP466722	24.1381
SIDM00251	STAD\|stomach	p.T935R (No)	GDSC	KU-55933	28.1082
SIDM00251	STAD\|stomach	p.T935R (No)	GDSC	KU-60019	33.9976
SIDM00251	STAD\|stomach	p.T1350M (No)	GDSC	CP466722	24.1381
SIDM00251	STAD\|stomach	p.T1350M (No)	GDSC	KU-55933	28.1082
SIDM00251	STAD\|stomach	p.T1350M (No)	GDSC	KU-60019	33.9976
SIDM00214	COREAD\|large_intestine	p.H1380Y (No)	GDSC	CP466722	9.9651
SIDM00214	COREAD\|large_intestine	p.H1380Y (No)	GDSC	KU-55933	85.1165
SIDM00214	COREAD\|large_intestine	p.H1380Y (No)	GDSC	KU-60019	81.4045
SIDM00844	UNCLASSIFIED\|Burkitt_lymphoma	p.L546V (No)	GDSC	CP466722	25.1532
SIDM00844	UNCLASSIFIED\|Burkitt_lymphoma	p.L546V (No)	GDSC	KU-55933	32.2639
SIDM00844	UNCLASSIFIED\|Burkitt_lymphoma	p.L546V (No)	GDSC	KU-60019	93.208
SIDM00844	UNCLASSIFIED\|Burkitt_lymphoma	p.P872S (No)	GDSC	CP466722	25.1532
SIDM00844	UNCLASSIFIED\|Burkitt_lymphoma	p.P872S (No)	GDSC	KU-55933	32.2639
SIDM00844	UNCLASSIFIED\|Burkitt_lymphoma	p.P872S (No)	GDSC	KU-60019	93.208
SIDM00844	UNCLASSIFIED\|Burkitt_lymphoma	p.L2332P (No)	GDSC	CP466722	25.1532
SIDM00844	UNCLASSIFIED\|Burkitt_lymphoma	p.L2332P (No)	GDSC	KU-55933	32.2639
SIDM00844	UNCLASSIFIED\|Burkitt_lymphoma	p.L2332P (No)	GDSC	KU-60019	93.208
SIDM00690	HNSC\|head_and_neck	p.A502G (No)	GDSC	KU-55933	166.7727
SIDM00690	HNSC\|head_and_neck	p.A502G (No)	GDSC	KU-60019	24.8056
SIDM00690	HNSC\|head_and_neck	p.Q1128R (No)	GDSC	KU-55933	166.7727
SIDM00690	HNSC\|head_and_neck	p.Q1128R (No)	GDSC	KU-60019	24.8056
SIDM01099	NB\|neuroblastoma	p.L546V (No)	GDSC	CP466722	9.972
SIDM01099	NB\|neuroblastoma	p.L546V (No)	GDSC	KU-55933	50.6314
SIDM01099	NB\|neuroblastoma	p.L546V (No)	GDSC	KU-60019	84.035
SIDM01099	NB\|neuroblastoma	p.P872S (No)	GDSC	CP466722	9.972
SIDM01099	NB\|neuroblastoma	p.P872S (No)	GDSC	KU-55933	50.6314
SIDM01099	NB\|neuroblastoma	p.P872S (No)	GDSC	KU-60019	84.035
SIDM01099	NB\|neuroblastoma	p.L2332P (No)	GDSC	CP466722	9.972
SIDM01099	NB\|neuroblastoma	p.L2332P (No)	GDSC	KU-55933	50.6314
SIDM01099	NB\|neuroblastoma	p.L2332P (No)	GDSC	KU-60019	84.035
SIDM01090	COREAD\|large_intestine	p.L546V (No)	GDSC	CP466722	6.9679
SIDM01090	COREAD\|large_intestine	p.L546V (No)	GDSC	KU-55933	46.2695
SIDM01090	COREAD\|large_intestine	p.L546V (No)	GDSC	KU-60019	10.9526
SIDM01090	COREAD\|large_intestine	p.P872S (No)	GDSC	CP466722	6.9679
SIDM01090	COREAD\|large_intestine	p.P872S (No)	GDSC	KU-55933	46.2695
SIDM01090	COREAD\|large_intestine	p.P872S (No)	GDSC	KU-60019	10.9526
SIDM01090	COREAD\|large_intestine	p.Q1128R (No)	GDSC	CP466722	6.9679
SIDM01090	COREAD\|large_intestine	p.Q1128R (No)	GDSC	KU-55933	46.2695
SIDM01090	COREAD\|large_intestine	p.Q1128R (No)	GDSC	KU-60019	10.9526
SIDM01090	COREAD\|large_intestine	p.L2332P (No)	GDSC	CP466722	6.9679
SIDM01090	COREAD\|large_intestine	p.L2332P (No)	GDSC	KU-55933	46.2695
SIDM01090	COREAD\|large_intestine	p.L2332P (No)	GDSC	KU-60019	10.9526
SIDM00945	COREAD\|large_intestine	p.E1533G (No)	GDSC	KU-55933	156.802
SIDM00945	COREAD\|large_intestine	p.E1533G (No)	GDSC	KU-60019	244.3718
SIDM01043	UNCLASSIFIED\|endometrium	p.E3015D (No)	GDSC	CP466722	10.9933
SIDM01043	UNCLASSIFIED\|endometrium	p.E3015D (No)	GDSC	KU-55933	29.616
SIDM01043	UNCLASSIFIED\|endometrium	p.E3015D (No)	GDSC	KU-60019	25.1955
SIDM00711	SCLC\|lung_small_cell_carcinoma	p.E2118V (No)	GDSC	KU-55933	274.5216
SIDM00711	SCLC\|lung_small_cell_carcinoma	p.E2118V (No)	GDSC	KU-60019	329.1979
SIDM01237	LIHC\|liver	p.V2906I (No)	GDSC	CP466722	226.1415
SIDM01237	LIHC\|liver	p.V2906I (No)	GDSC	KU-55933	86.2052
SIDM01237	LIHC\|liver	p.V2906I (No)	GDSC	KU-60019	20.9059
SIDM00518	MESO\|mesothelioma	p.D351N (No)	GDSC	CP466722	3.4178
SIDM00518	MESO\|mesothelioma	p.D351N (No)	GDSC	KU-55933	76.5315
SIDM00518	MESO\|mesothelioma	p.D351N (No)	GDSC	KU-60019	13.7676
SIDM01201	UNCLASSIFIED\|lymphoid_neoplasm_other	p.C1726F (No)	GDSC	CP466722	5.6915
SIDM00488	COREAD\|large_intestine	p.H1380Y (No)	GDSC	CP466722	21.3025
SIDM00488	COREAD\|large_intestine	p.H1380Y (No)	GDSC	KU-55933	57.2832
SIDM00488	COREAD\|large_intestine	p.H1380Y (No)	GDSC	KU-60019	48.6735
SIDM00194	COREAD\|large_intestine	p.I2920N (No)	GDSC	CP466722	15.3863
SIDM00194	COREAD\|large_intestine	p.I2920N (No)	GDSC	KU-55933	439.7375
SIDM00194	COREAD\|large_intestine	p.I2920N (No)	GDSC	KU-60019	353.7895
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.T1854I (No)	GDSC	CP466722	5.8645
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.T1854I (No)	GDSC	KU-55933	9.8274
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.T1854I (No)	GDSC	KU-60019	5.5191
SIDM00370	ALL\|lymphoblastic_T_cell_leukaemia	p.N1650S (No)	GDSC	CP466722	11.9526
SIDM01163	LUAD\|lung_NSCLC_adenocarcinoma	p.S49C (No)	GDSC	CP466722	24.7852
SIDM01163	LUAD\|lung_NSCLC_adenocarcinoma	p.S49C (No)	GDSC	KU-55933	112.674
SIDM01163	LUAD\|lung_NSCLC_adenocarcinoma	p.S49C (No)	GDSC	KU-60019	58.0053
SIDM00767	SCLC\|lung_small_cell_carcinoma	p.R2244T (No)	GDSC	CP466722	10.7258
SIDM00767	SCLC\|lung_small_cell_carcinoma	p.R2244T (No)	GDSC	KU-55933	102.4105
SIDM00767	SCLC\|lung_small_cell_carcinoma	p.R2244T (No)	GDSC	KU-60019	89.2847
SIDM01148	MM\|myeloma	p.E347K (No)	GDSC	KU-55933	9.7594
SIDM01148	MM\|myeloma	p.E347K (No)	GDSC	KU-60019	7.4471
SIDM00833	COREAD\|large_intestine	p.H448R (No)	GDSC	CP466722	8.6293
SIDM00833	COREAD\|large_intestine	p.H448R (No)	GDSC	KU-55933	274.0921
SIDM00833	COREAD\|large_intestine	p.H448R (No)	GDSC	KU-60019	37.8348
SIDM01028	ESCA\|oesophagus	p.M1I (No)	GDSC	CP466722	21.3838
SIDM01028	ESCA\|oesophagus	p.M1I (No)	GDSC	KU-55933	81.9141
SIDM01028	ESCA\|oesophagus	p.M1I (No)	GDSC	KU-60019	5.7178
SIDM01028	ESCA\|oesophagus	p.S2C (No)	GDSC	CP466722	21.3838
SIDM01028	ESCA\|oesophagus	p.S2C (No)	GDSC	KU-55933	81.9141
SIDM01028	ESCA\|oesophagus	p.S2C (No)	GDSC	KU-60019	5.7178
SIDM01028	ESCA\|oesophagus	p.D2661N (No)	GDSC	CP466722	21.3838
SIDM01028	ESCA\|oesophagus	p.D2661N (No)	GDSC	KU-55933	81.9141
SIDM01028	ESCA\|oesophagus	p.D2661N (No)	GDSC	KU-60019	5.7178
SIDM01121	SCLC\|lung_small_cell_carcinoma	p.M1064I (No)	GDSC	CP466722	7.7549
SIDM01121	SCLC\|lung_small_cell_carcinoma	p.M1064I (No)	GDSC	KU-55933	77.843
SIDM01121	SCLC\|lung_small_cell_carcinoma	p.M1064I (No)	GDSC	KU-60019	89.5544
SIDM00486	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.K2318Q (No)	GDSC	CP466722	15.4957
SIDM00486	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.K2318Q (No)	GDSC	KU-55933	37.9898
SIDM00486	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.K2318Q (No)	GDSC	KU-60019	2.4075
SIDM00689	DLBC\|B_cell_lymphoma	p.S707P (No)	GDSC	CP466722	3.1523
SIDM00689	DLBC\|B_cell_lymphoma	p.S707P (No)	GDSC	KU-55933	21.155
SIDM00689	DLBC\|B_cell_lymphoma	p.S707P (No)	GDSC	KU-60019	16.929
SIDM00303	OV\|ovary	p.T2674R (No)	GDSC	KU-55933	108.1405
SIDM00303	OV\|ovary	p.T2674R (No)	GDSC	KU-60019	33.198
SIDM01265	MM\|myeloma	p.H1380Y (No)	GDSC	KU-55933	23.1267
SIDM01265	MM\|myeloma	p.H1380Y (No)	GDSC	KU-60019	30.0764
SIDM00211	ALL\|lymphoblastic_leukemia	p.K1572T (No)	GDSC	CP466722	0.4695
SIDM00211	ALL\|lymphoblastic_leukemia	p.K1572T (No)	GDSC	KU-55933	6.7435
SIDM00211	ALL\|lymphoblastic_leukemia	p.K1572T (No)	GDSC	KU-60019	2.8429
SIDM00333	UCEC\|endometrium	p.F1896L (No)	GDSC	CP466722	3.3398
SIDM00333	UCEC\|endometrium	p.F1896L (No)	GDSC	KU-55933	16.5104
SIDM00333	UCEC\|endometrium	p.F1896L (No)	GDSC	KU-60019	9.1851
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.T935R (No)	GDSC	CP466722	6.9805
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.T935R (No)	GDSC	KU-55933	42.9438
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.T935R (No)	GDSC	KU-60019	11.6779
SIDM00687	STAD\|stomach	p.S2581I (No)	GDSC	KU-55933	44.5342
SIDM00687	STAD\|stomach	p.S2581I (No)	GDSC	KU-60019	20.9802
SIDM00256	NB\|neuroblastoma	p.M779I (No)	GDSC	CP466722	10.4572
SIDM00256	NB\|neuroblastoma	p.M779I (No)	GDSC	KU-55933	39.9902
SIDM00256	NB\|neuroblastoma	p.M779I (No)	GDSC	KU-60019	5.8728
SIDM00999	BLCA\|bladder	p.R2461C (No)	GDSC	CP466722	20.4465
SIDM00999	BLCA\|bladder	p.R2461C (No)	GDSC	KU-55933	9.9374
SIDM00999	BLCA\|bladder	p.R2461C (No)	GDSC	KU-60019	5.5367
SIDM00999	BLCA\|bladder	p.T2921M (No)	GDSC	CP466722	20.4465
SIDM00999	BLCA\|bladder	p.T2921M (No)	GDSC	KU-55933	9.9374
SIDM00999	BLCA\|bladder	p.T2921M (No)	GDSC	KU-60019	5.5367
SIDM00590	HNSC\|head_and_neck	p.L581V (No)	GDSC	CP466722	32.072
SIDM00590	HNSC\|head_and_neck	p.L581V (No)	GDSC	KU-55933	46.2253
SIDM00590	HNSC\|head_and_neck	p.L581V (No)	GDSC	KU-60019	18.3332
SIDM00590	HNSC\|head_and_neck	p.I2606V (No)	GDSC	CP466722	32.072
SIDM00590	HNSC\|head_and_neck	p.I2606V (No)	GDSC	KU-55933	46.2253
SIDM00590	HNSC\|head_and_neck	p.I2606V (No)	GDSC	KU-60019	18.3332
SIDM00217	COREAD\|large_intestine	p.V2587M (No)	GDSC	CP466722	5.7215
SIDM00599	UNCLASSIFIED\|osteosarcoma	p.H1380Y (No)	GDSC	CP466722	2.5855
SIDM00599	UNCLASSIFIED\|osteosarcoma	p.H1380Y (No)	GDSC	KU-55933	31.9066
SIDM00599	UNCLASSIFIED\|osteosarcoma	p.H1380Y (No)	GDSC	KU-60019	10.1242
SIDM00893	BRCA\|breast	p.K482Q (No)	GDSC	CP466722	7.9083
SIDM00893	BRCA\|breast	p.K482Q (No)	GDSC	KU-55933	189.479
SIDM00893	BRCA\|breast	p.K482Q (No)	GDSC	KU-60019	31.6296
SIDM00893	BRCA\|breast	p.K482Q (No)	GDSC	KU-55933	58.635
SIDM01003	ALL\|lymphoblastic_leukemia	p.S1383L (No)	GDSC	CP466722	0.7206
SIDM01003	ALL\|lymphoblastic_leukemia	p.S1383L (No)	GDSC	KU-55933	19.0543
SIDM01003	ALL\|lymphoblastic_leukemia	p.S1383L (No)	GDSC	KU-60019	10.3354
SIDM00807	BLCA\|bladder	p.H1876Q (No)	GDSC	CP466722	6.0513
SIDM00807	BLCA\|bladder	p.H1876Q (No)	GDSC	KU-55933	24.038
SIDM00807	BLCA\|bladder	p.H1876Q (No)	GDSC	KU-60019	7.8501
SIDM00631	BRCA\|breast	p.D1853V (No)	GDSC	CP466722	5.6566
SIDM00631	BRCA\|breast	p.D1853V (No)	GDSC	KU-55933	77.5426
SIDM00631	BRCA\|breast	p.D1853V (No)	GDSC	KU-55933	198.9
SIDM00435	LAML\|acute_myeloid_leukaemia	p.H1380Y (No)	GDSC	KU-55933	5.9184
SIDM00435	LAML\|acute_myeloid_leukaemia	p.H1380Y (No)	GDSC	KU-60019	4.3321
SIDM00993	MM\|haematopoietic_neoplasm_other	p.H291R (No)	GDSC	CP466722	5.5771
SIDM00993	MM\|haematopoietic_neoplasm_other	p.H291R (No)	GDSC	KU-55933	87.57
SIDM00993	MM\|haematopoietic_neoplasm_other	p.H291R (No)	GDSC	KU-60019	89.0979
SIDM01042	BRCA\|breast	p.L1472F (No)	GDSC	CP466722	23.5375
SIDM01042	BRCA\|breast	p.L1472F (No)	GDSC	KU-55933	10.6773
SIDM01042	BRCA\|breast	p.L1472F (No)	GDSC	KU-60019	39.0195
SIDM01042	BRCA\|breast	p.L1472F (No)	GDSC	KU-55933	21.593
SIDM00276	UNCLASSIFIED\|biliary_tract	p.H1380Y (No)	GDSC	CP466722	27.5462
SIDM00276	UNCLASSIFIED\|biliary_tract	p.H1380Y (No)	GDSC	KU-55933	53.4153
SIDM00276	UNCLASSIFIED\|biliary_tract	p.H1380Y (No)	GDSC	KU-60019	12.04
SIDM00552	UNCLASSIFIED\|rhabdomyosarcoma	p.H1380Y (No)	GDSC	CP466722	24.7221
SIDM00552	UNCLASSIFIED\|rhabdomyosarcoma	p.H1380Y (No)	GDSC	KU-55933	17.7192
SIDM00552	UNCLASSIFIED\|rhabdomyosarcoma	p.H1380Y (No)	GDSC	KU-60019	7.1847
SIDM00492	GBM\|glioma	p.P2974L (No)	GDSC	CP466722	4.3806
SIDM00492	GBM\|glioma	p.P2974L (No)	GDSC	KU-55933	50.7788
SIDM00492	GBM\|glioma	p.P2974L (No)	GDSC	KU-60019	14.8707
SIDM00596	UCEC\|endometrium	p.P2353H (No)	GDSC	CP466722	63.9709
SIDM00596	UCEC\|endometrium	p.P2353H (No)	GDSC	KU-55933	37.4178
SIDM00596	UCEC\|endometrium	p.P2353H (No)	GDSC	KU-60019	11.315
SIDM00282	COREAD\|large_intestine	p.A2843V (No)	GDSC	CP466722	83.8915
SIDM00282	COREAD\|large_intestine	p.A2843V (No)	GDSC	KU-55933	171.1443
SIDM00282	COREAD\|large_intestine	p.A2843V (No)	GDSC	KU-60019	12.7693
SIDM01057	LAML\|acute_myeloid_leukaemia	p.V410A (No)	GDSC	CP466722	1.7415
SIDM01057	LAML\|acute_myeloid_leukaemia	p.V410A (No)	GDSC	KU-55933	127.6806
SIDM01057	LAML\|acute_myeloid_leukaemia	p.V410A (No)	GDSC	KU-60019	145.3841
SIDM00150	COREAD\|large_intestine	p.Q2762R (No)	GDSC	CP466722	6.4536
SIDM00150	COREAD\|large_intestine	p.Q2762R (No)	GDSC	KU-55933	107.2444
SIDM00150	COREAD\|large_intestine	p.Q2762R (No)	GDSC	KU-60019	9.0626
SIDM00522	SCLC\|lung_small_cell_carcinoma	p.L345F (No)	GDSC	CP466722	4.7815
SIDM00522	SCLC\|lung_small_cell_carcinoma	p.L345F (No)	GDSC	KU-55933	23.5765
SIDM00522	SCLC\|lung_small_cell_carcinoma	p.L345F (No)	GDSC	KU-60019	23.8055
SIDM00543	SKCM\|melanoma	p.I1688T (No)	GDSC	CP466722	10.144
SIDM00543	SKCM\|melanoma	p.I1688T (No)	GDSC	KU-55933	62.2446
SIDM00543	SKCM\|melanoma	p.I1688T (No)	GDSC	KU-60019	15.2357
SIDM00760	SCLC\|lung_small_cell_carcinoma	p.G514D (No)	GDSC	KU-60019	75.8417
SIDM00760	SCLC\|lung_small_cell_carcinoma	p.H1380Y (No)	GDSC	KU-60019	75.8417
SIDM00197	UNCLASSIFIED\|ewings_sarcoma	p.S49C (No)	GDSC	CP466722	2.1727
SIDM00197	UNCLASSIFIED\|ewings_sarcoma	p.S49C (No)	GDSC	KU-55933	14.7631
SIDM00197	UNCLASSIFIED\|ewings_sarcoma	p.S49C (No)	GDSC	KU-60019	25.377
SIDM00740	UNCLASSIFIED\|lung_NSCLC_adenocarcinoma	p.V1521L (No)	GDSC	CP466722	3.658
SIDM00740	UNCLASSIFIED\|lung_NSCLC_adenocarcinoma	p.V1521L (No)	GDSC	KU-55933	117.0102
SIDM00740	UNCLASSIFIED\|lung_NSCLC_adenocarcinoma	p.V1521L (No)	GDSC	KU-60019	20.811
SIDM00740	UNCLASSIFIED\|lung_NSCLC_adenocarcinoma	p.G1998E (No)	GDSC	CP466722	3.658
SIDM00740	UNCLASSIFIED\|lung_NSCLC_adenocarcinoma	p.G1998E (No)	GDSC	KU-55933	117.0102
SIDM00740	UNCLASSIFIED\|lung_NSCLC_adenocarcinoma	p.G1998E (No)	GDSC	KU-60019	20.811
SIDM01147	STAD\|stomach	p.V2079I (No)	GDSC	KU-55933	284.2093
SIDM01147	STAD\|stomach	p.V2079I (No)	GDSC	KU-60019	28.228
SIDM01147	STAD\|stomach	p.S2146T (No)	GDSC	KU-55933	284.2093
SIDM01147	STAD\|stomach	p.S2146T (No)	GDSC	KU-60019	28.228
SIDM01050	UNCLASSIFIED\|biliary_tract	p.W57* (No)	GDSC	CP466722	9.8932
SIDM01050	UNCLASSIFIED\|biliary_tract	p.W57* (No)	GDSC	KU-55933	220.6556
SIDM01050	UNCLASSIFIED\|biliary_tract	p.W57* (No)	GDSC	KU-60019	22.7992
SIDM00783	COREAD\|large_intestine	p.A1127V (No)	GDSC	CP466722	4.4645
SIDM00783	COREAD\|large_intestine	p.A1127V (No)	GDSC	KU-55933	55.7742
SIDM00783	COREAD\|large_intestine	p.A1127V (No)	GDSC	KU-60019	6.6787
SIDM00973	SKCM\|melanoma	p.L2307F (No)	GDSC	CP466722	177.7518
SIDM00973	SKCM\|melanoma	p.L2307F (No)	GDSC	KU-55933	127.8154
SIDM00973	SKCM\|melanoma	p.L2307F (No)	GDSC	KU-60019	8.4099
SIDM00462	LAML\|acute_myeloid_leukaemia	p.S707P (No)	GDSC	CP466722	9.4258
SIDM00462	LAML\|acute_myeloid_leukaemia	p.S707P (No)	GDSC	KU-55933	53.0692
SIDM00462	LAML\|acute_myeloid_leukaemia	p.S707P (No)	GDSC	KU-60019	55.2705
SIDM00703	UNCLASSIFIED\|lung_NSCLC_not_specified	p.I1453T (No)	GDSC	CP466722	5.7921
SIDM00703	UNCLASSIFIED\|lung_NSCLC_not_specified	p.I1453T (No)	GDSC	KU-55933	48.8093
SIDM00703	UNCLASSIFIED\|lung_NSCLC_not_specified	p.I1453T (No)	GDSC	KU-60019	15.0147
SIDM00954	BRCA\|breast	p.G514D (No)	GDSC	CP466722	22.6685
SIDM00954	BRCA\|breast	p.G514D (No)	GDSC	KU-55933	99.4517
SIDM00954	BRCA\|breast	p.G514D (No)	GDSC	KU-60019	12.8525
SIDM00954	BRCA\|breast	p.G514D (No)	GDSC	KU-55933	73.515
SIDM00954	BRCA\|breast	p.H1380Y (No)	GDSC	CP466722	22.6685
SIDM00954	BRCA\|breast	p.H1380Y (No)	GDSC	KU-55933	99.4517
SIDM00954	BRCA\|breast	p.H1380Y (No)	GDSC	KU-60019	12.8525
SIDM00954	BRCA\|breast	p.H1380Y (No)	GDSC	KU-55933	73.515
SIDM00954	BRCA\|breast	p.P2518S (No)	GDSC	CP466722	22.6685
SIDM00954	BRCA\|breast	p.P2518S (No)	GDSC	KU-55933	99.4517
SIDM00954	BRCA\|breast	p.P2518S (No)	GDSC	KU-60019	12.8525
SIDM00954	BRCA\|breast	p.P2518S (No)	GDSC	KU-55933	73.515
SIDM00739	LUAD\|lung_NSCLC_adenocarcinoma	p.Q65P (No)	GDSC	CP466722	17.9067
SIDM00739	LUAD\|lung_NSCLC_adenocarcinoma	p.Q65P (No)	GDSC	KU-60019	9.1608
SIDM00297	LUAD\|lung_NSCLC_adenocarcinoma	p.H1380Y (No)	GDSC	CP466722	3.4757
SIDM00297	LUAD\|lung_NSCLC_adenocarcinoma	p.H1380Y (No)	GDSC	KU-55933	25.7827
SIDM00297	LUAD\|lung_NSCLC_adenocarcinoma	p.H1380Y (No)	GDSC	KU-60019	39.6456
SIDM00125	KIRC\|kidney	p.R2436S (No)	GDSC	CP466722	3.8458
SIDM00125	KIRC\|kidney	p.R2436S (No)	GDSC	KU-55933	32.4345
SIDM00125	KIRC\|kidney	p.R2436S (No)	GDSC	KU-60019	16.1054
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.G2022V (No)	GDSC	CP466722	39.6673
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.G2022V (No)	GDSC	KU-55933	32.7138
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.G2022V (No)	GDSC	KU-60019	50.1843
SIDM00987	THCA\|thyroid	p.D2721N (No)	GDSC	CP466722	6.7859
SIDM00987	THCA\|thyroid	p.D2721N (No)	GDSC	KU-55933	14.3555
SIDM00987	THCA\|thyroid	p.D2721N (No)	GDSC	KU-60019	14.91
SIDM00987	THCA\|thyroid	p.V2906A (No)	GDSC	CP466722	6.7859
SIDM00987	THCA\|thyroid	p.V2906A (No)	GDSC	KU-55933	14.3555
SIDM00987	THCA\|thyroid	p.V2906A (No)	GDSC	KU-60019	14.91
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.A1309T (No)	GDSC	CP466722	3.9058
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.A1309T (No)	GDSC	KU-55933	15.3452
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.A1309T (No)	GDSC	KU-60019	27.0041
SIDM00090	OV\|ovary	p.V613L (No)	GDSC	CP466722	6.9185
SIDM00090	OV\|ovary	p.V613L (No)	GDSC	KU-55933	31.8651
SIDM00090	OV\|ovary	p.V613L (No)	GDSC	KU-60019	26.3512
SIDM00789	COREAD\|large_intestine	p.E586D (No)	GDSC	CP466722	6.3092
SIDM00789	COREAD\|large_intestine	p.E586D (No)	GDSC	KU-55933	40.7105
SIDM00789	COREAD\|large_intestine	p.E586D (No)	GDSC	KU-60019	16.7674
SIDM00534	COREAD\|large_intestine	p.D130Y (No)	GDSC	CP466722	37.9906
SIDM00534	COREAD\|large_intestine	p.D130Y (No)	GDSC	KU-55933	67.3369
SIDM00534	COREAD\|large_intestine	p.D130Y (No)	GDSC	KU-60019	34.1273
SIDM01169	OV\|ovary	p.S707P (No)	GDSC	CP466722	7.3272
SIDM01169	OV\|ovary	p.S707P (No)	GDSC	KU-55933	52.5481
SIDM01169	OV\|ovary	p.S707P (No)	GDSC	KU-60019	11.1761
SIDM00414	BLCA\|bladder	p.L243W (No)	GDSC	CP466722	11.1837
SIDM00414	BLCA\|bladder	p.L243W (No)	GDSC	KU-55933	11.7223
SIDM00414	BLCA\|bladder	p.L243W (No)	GDSC	KU-60019	14.9655
SIDM00493	UNCLASSIFIED\|lung_NSCLC_adenocarcinoma	p.L546V (No)	GDSC	CP466722	4.0334
SIDM00493	UNCLASSIFIED\|lung_NSCLC_adenocarcinoma	p.L546V (No)	GDSC	KU-55933	95.652
SIDM00493	UNCLASSIFIED\|lung_NSCLC_adenocarcinoma	p.L546V (No)	GDSC	KU-60019	6.7766
SIDM00493	UNCLASSIFIED\|lung_NSCLC_adenocarcinoma	p.P872S (No)	GDSC	CP466722	4.0334
SIDM00493	UNCLASSIFIED\|lung_NSCLC_adenocarcinoma	p.P872S (No)	GDSC	KU-55933	95.652
SIDM00493	UNCLASSIFIED\|lung_NSCLC_adenocarcinoma	p.P872S (No)	GDSC	KU-60019	6.7766
SIDM00963	BRCA\|breast	p.E2468K (No)	GDSC	CP466722	9.1575
SIDM00963	BRCA\|breast	p.E2468K (No)	GDSC	KU-55933	209.0783
SIDM00963	BRCA\|breast	p.E2468K (No)	GDSC	KU-60019	62.3101
SIDM00963	BRCA\|breast	p.E2468K (No)	GDSC	KU-55933	467.34
SIDM00342	ALL\|lymphoblastic_T_cell_leukaemia	p.N1005S (No)	GDSC	CP466722	1.1451
SIDM00342	ALL\|lymphoblastic_T_cell_leukaemia	p.N1005S (No)	GDSC	KU-55933	10.1862
SIDM00342	ALL\|lymphoblastic_T_cell_leukaemia	p.N1005S (No)	GDSC	KU-60019	10.0103
SIDM00270	HNSC\|head_and_neck	p.S49C (No)	GDSC	CP466722	12.1114
SIDM00270	HNSC\|head_and_neck	p.S49C (No)	GDSC	KU-55933	2.5593
SIDM00270	HNSC\|head_and_neck	p.S49C (No)	GDSC	KU-60019	19.7755
SIDM01116	UNCLASSIFIED\|lung_NSCLC_large_cell	p.C1482R (No)	GDSC	CP466722	4.1255
SIDM01116	UNCLASSIFIED\|lung_NSCLC_large_cell	p.C1482R (No)	GDSC	KU-55933	82.8629
SIDM01116	UNCLASSIFIED\|lung_NSCLC_large_cell	p.C1482R (No)	GDSC	KU-60019	93.3002
SIDM00092	OV\|ovary	p.N230T (No)	GDSC	CP466722	10.0654
SIDM00092	OV\|ovary	p.N230T (No)	GDSC	KU-55933	48.8046
SIDM00092	OV\|ovary	p.N230T (No)	GDSC	KU-60019	25.723
SIDM00330	NB\|neuroblastoma	p.S2218R (No)	GDSC	CP466722	17.5511
SIDM00330	NB\|neuroblastoma	p.S2218R (No)	GDSC	KU-55933	201.1273
SIDM00330	NB\|neuroblastoma	p.S2218R (No)	GDSC	KU-60019	55.1851
SIDM00628	BRCA\|breast	p.G514D (No)	GDSC	CP466722	4.6893
SIDM00628	BRCA\|breast	p.G514D (No)	GDSC	KU-55933	15.3867
SIDM00628	BRCA\|breast	p.G514D (No)	GDSC	KU-60019	20.91
SIDM00628	BRCA\|breast	p.G514D (No)	GDSC	KU-55933	43.148
SIDM00628	BRCA\|breast	p.H1380Y (No)	GDSC	CP466722	4.6893
SIDM00628	BRCA\|breast	p.H1380Y (No)	GDSC	KU-55933	15.3867
SIDM00628	BRCA\|breast	p.H1380Y (No)	GDSC	KU-60019	20.91
SIDM00628	BRCA\|breast	p.H1380Y (No)	GDSC	KU-55933	43.148
SIDM01136	PAAD\|pancreas	p.F1234S (No)	GDSC	CP466722	15.7891
SIDM01136	PAAD\|pancreas	p.F1234S (No)	GDSC	KU-55933	12.1619
SIDM01136	PAAD\|pancreas	p.F1234S (No)	GDSC	KU-60019	23.4037
SIDM00114	MESO\|mesothelioma	p.D1725H (No)	GDSC	CP466722	73.7346
SIDM00114	MESO\|mesothelioma	p.D1725H (No)	GDSC	KU-55933	24.5058
SIDM00114	MESO\|mesothelioma	p.D1725H (No)	GDSC	KU-60019	193.3473
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.E848Q (Yes)	GDSC	CP466722	5.9923
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.E848Q (Yes)	GDSC	KU-55933	104.4979
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.E848Q (Yes)	GDSC	KU-60019	37.8725
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.L2965F (No)	GDSC	CP466722	5.9923
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.L2965F (No)	GDSC	KU-55933	104.4979
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.L2965F (No)	GDSC	KU-60019	37.8725
SIDM00290	STAD\|stomach	p.P2648S (No)	GDSC	CP466722	8.8153
SIDM00290	STAD\|stomach	p.P2648S (No)	GDSC	KU-55933	52.1136
SIDM00290	STAD\|stomach	p.P2648S (No)	GDSC	KU-60019	11.9999
SIDM00930	UNCLASSIFIED\|osteosarcoma	p.L546V (No)	GDSC	CP466722	451.0323
SIDM00930	UNCLASSIFIED\|osteosarcoma	p.L546V (No)	GDSC	KU-55933	18.885
SIDM00930	UNCLASSIFIED\|osteosarcoma	p.L546V (No)	GDSC	KU-60019	43.1158
SIDM00934	PAAD\|pancreas	p.R1585S (No)	GDSC	CP466722	10.5201
SIDM00934	PAAD\|pancreas	p.R1585S (No)	GDSC	KU-55933	50.6521
SIDM00934	PAAD\|pancreas	p.R1585S (No)	GDSC	KU-60019	172.5702
SIDM00855	UNCLASSIFIED\|soft_tissue_other	p.G514D (No)	GDSC	CP466722	4.3361
SIDM00855	UNCLASSIFIED\|soft_tissue_other	p.G514D (No)	GDSC	KU-55933	104.2294
SIDM00855	UNCLASSIFIED\|soft_tissue_other	p.G514D (No)	GDSC	KU-60019	13.3383
SIDM00855	UNCLASSIFIED\|soft_tissue_other	p.H1380Y (No)	GDSC	CP466722	4.3361
SIDM00855	UNCLASSIFIED\|soft_tissue_other	p.H1380Y (No)	GDSC	KU-55933	104.2294
SIDM00855	UNCLASSIFIED\|soft_tissue_other	p.H1380Y (No)	GDSC	KU-60019	13.3383
SIDM01173	UNCLASSIFIED\|rhabdomyosarcoma	p.V2079I (No)	GDSC	CP466722	8.1474
SIDM00750	LUAD\|lung_NSCLC_adenocarcinoma	p.G506C (No)	GDSC	CP466722	13.8211
SIDM00750	LUAD\|lung_NSCLC_adenocarcinoma	p.G506C (No)	GDSC	KU-55933	92.92
SIDM00750	LUAD\|lung_NSCLC_adenocarcinoma	p.G506C (No)	GDSC	KU-60019	13.7936
SIDM00750	LUAD\|lung_NSCLC_adenocarcinoma	p.G506V (No)	GDSC	CP466722	13.8211
SIDM00750	LUAD\|lung_NSCLC_adenocarcinoma	p.G506V (No)	GDSC	KU-55933	92.92
SIDM00750	LUAD\|lung_NSCLC_adenocarcinoma	p.G506V (No)	GDSC	KU-60019	13.7936
SIDM00895	DLBC\|B_cell_lymphoma	p.H1083Y (No)	GDSC	CP466722	3.6135
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.M1967V (No)	GDSC	CP466722	1.8575
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.M1967V (No)	GDSC	KU-55933	16.0779
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.M1967V (No)	GDSC	KU-60019	50.4093
SIDM00364	ALL\|lymphoblastic_leukemia	p.R1304G (No)	GDSC	CP466722	1.3961
SIDM00364	ALL\|lymphoblastic_leukemia	p.R1304G (No)	GDSC	KU-55933	16.0224
SIDM00364	ALL\|lymphoblastic_leukemia	p.R1304G (No)	GDSC	KU-60019	5.6438
SIDM00364	ALL\|lymphoblastic_leukemia	p.K2318Q (No)	GDSC	CP466722	1.3961
SIDM00364	ALL\|lymphoblastic_leukemia	p.K2318Q (No)	GDSC	KU-55933	16.0224
SIDM00364	ALL\|lymphoblastic_leukemia	p.K2318Q (No)	GDSC	KU-60019	5.6438
SIDM00360	UNCLASSIFIED\|pancreas	p.K2749I (No)	GDSC	CP466722	84.5354
SIDM00360	UNCLASSIFIED\|pancreas	p.K2749I (No)	GDSC	KU-55933	276.4638
SIDM00360	UNCLASSIFIED\|pancreas	p.K2749I (No)	GDSC	KU-60019	514.4827
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.R1086H (No)	GDSC	CP466722	19.6663
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.R1086H (No)	GDSC	KU-55933	20.4412
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.R1086H (No)	GDSC	KU-60019	14.3123
SIDM00803	KIRC\|kidney	p.S49C (No)	GDSC	CP466722	4.8782
SIDM00803	KIRC\|kidney	p.S49C (No)	GDSC	KU-55933	77.7822
SIDM00803	KIRC\|kidney	p.S49C (No)	GDSC	KU-60019	9.2848
SIDM00339	LUAD\|lung_NSCLC_adenocarcinoma	p.E632Q (No)	GDSC	CP466722	4.0758
SIDM00339	LUAD\|lung_NSCLC_adenocarcinoma	p.E632Q (No)	GDSC	KU-55933	12.4282
SIDM00339	LUAD\|lung_NSCLC_adenocarcinoma	p.E632Q (No)	GDSC	KU-60019	5.0563
SIDM01172	LAML\|acute_myeloid_leukaemia	p.T935R (No)	GDSC	CP466722	3.2736
SIDM01172	LAML\|acute_myeloid_leukaemia	p.T935R (No)	GDSC	KU-55933	41.9641
SIDM01172	LAML\|acute_myeloid_leukaemia	p.T935R (No)	GDSC	KU-60019	22.6005
SIDM00346	LCML\|chronic_myeloid_leukaemia	p.Q1128R (No)	GDSC	CP466722	1.7334
SIDM00346	LCML\|chronic_myeloid_leukaemia	p.Q1128R (No)	GDSC	KU-55933	9.9189
SIDM00346	LCML\|chronic_myeloid_leukaemia	p.Q1128R (No)	GDSC	KU-60019	10.5272
SIDM00222	MESO\|mesothelioma	p.V2079I (No)	GDSC	CP466722	30.5113
SIDM00222	MESO\|mesothelioma	p.V2079I (No)	GDSC	KU-55933	64.5144
SIDM00222	MESO\|mesothelioma	p.V2079I (No)	GDSC	KU-60019	16.748
SIDM01138	PAAD\|pancreas	p.E2351G (No)	GDSC	CP466722	9.846
SIDM01138	PAAD\|pancreas	p.E2351G (No)	GDSC	KU-55933	21.6896
SIDM01138	PAAD\|pancreas	p.E2351G (No)	GDSC	KU-60019	13.3787
SIDM01070	UNCLASSIFIED\|lung_NSCLC_not_specified	p.P534A (No)	GDSC	KU-55933	112.3626
SIDM01070	UNCLASSIFIED\|lung_NSCLC_not_specified	p.P534A (No)	GDSC	KU-60019	45.5759
SIDM01130	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.P383A (No)	GDSC	CP466722	6.9812
SIDM01130	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.P383A (No)	GDSC	KU-55933	46.5827
SIDM01130	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.P383A (No)	GDSC	KU-60019	59.1653
SIDM00815	OV\|ovary	p.D1853V (No)	GDSC	CP466722	29.7518
SIDM00815	OV\|ovary	p.D1853V (No)	GDSC	KU-55933	53.4559
SIDM00815	OV\|ovary	p.D1853V (No)	GDSC	KU-60019	66.8804
SIDM00203	UNCLASSIFIED\|ewings_sarcoma	p.P604S (No)	GDSC	CP466722	2.4164
SIDM00203	UNCLASSIFIED\|ewings_sarcoma	p.P604S (No)	GDSC	KU-55933	222.3341
SIDM00203	UNCLASSIFIED\|ewings_sarcoma	p.P604S (No)	GDSC	KU-60019	124.6587
SIDM00203	UNCLASSIFIED\|ewings_sarcoma	p.F1463C (No)	GDSC	CP466722	2.4164
SIDM00203	UNCLASSIFIED\|ewings_sarcoma	p.F1463C (No)	GDSC	KU-55933	222.3341
SIDM00203	UNCLASSIFIED\|ewings_sarcoma	p.F1463C (No)	GDSC	KU-60019	124.6587
SIDM00383	UNCLASSIFIED\|stomach	p.H1380Y (No)	GDSC	CP466722	121.8341
SIDM00383	UNCLASSIFIED\|stomach	p.H1380Y (No)	GDSC	KU-55933	83.9094
SIDM00383	UNCLASSIFIED\|stomach	p.H1380Y (No)	GDSC	KU-60019	71.3342
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.N1223S (No)	GDSC	CP466722	10.2346
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.N1223S (No)	GDSC	KU-55933	73.1659
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.N1223S (No)	GDSC	KU-60019	129.4098
SIDM01178	UNCLASSIFIED\|urogenital_system_other	p.G2917R (No)	GDSC	CP466722	26.9073
SIDM01178	UNCLASSIFIED\|urogenital_system_other	p.G2917R (No)	GDSC	KU-55933	31.4707
SIDM01178	UNCLASSIFIED\|urogenital_system_other	p.G2917R (No)	GDSC	KU-60019	23.7845
SIDM00694	UNCLASSIFIED\|digestive_system_other	p.G514D (No)	GDSC	CP466722	2.8315
SIDM00694	UNCLASSIFIED\|digestive_system_other	p.G514D (No)	GDSC	KU-55933	32.5724
SIDM00694	UNCLASSIFIED\|digestive_system_other	p.G514D (No)	GDSC	KU-60019	12.2124
SIDM00694	UNCLASSIFIED\|digestive_system_other	p.H1380Y (No)	GDSC	CP466722	2.8315
SIDM00694	UNCLASSIFIED\|digestive_system_other	p.H1380Y (No)	GDSC	KU-55933	32.5724
SIDM00694	UNCLASSIFIED\|digestive_system_other	p.H1380Y (No)	GDSC	KU-60019	12.2124
SIDM00423	DLBC\|B_cell_lymphoma	p.K1964E (No)	GDSC	CP466722	2.5191
SIDM00423	DLBC\|B_cell_lymphoma	p.K1964E (No)	GDSC	KU-55933	86.1171
SIDM00423	DLBC\|B_cell_lymphoma	p.K1964E (No)	GDSC	KU-60019	24.9065
SIDM00808	UNCLASSIFIED\|Burkitt_lymphoma	p.G514D (No)	GDSC	CP466722	25.908
SIDM00808	UNCLASSIFIED\|Burkitt_lymphoma	p.G514D (No)	GDSC	KU-55933	24.7171
SIDM00808	UNCLASSIFIED\|Burkitt_lymphoma	p.G514D (No)	GDSC	KU-60019	68.4192
SIDM00808	UNCLASSIFIED\|Burkitt_lymphoma	p.H1380Y (No)	GDSC	CP466722	25.908
SIDM00808	UNCLASSIFIED\|Burkitt_lymphoma	p.H1380Y (No)	GDSC	KU-55933	24.7171
SIDM00808	UNCLASSIFIED\|Burkitt_lymphoma	p.H1380Y (No)	GDSC	KU-60019	68.4192
SIDM00384	DLBC\|B_cell_lymphoma	p.H1380Y (No)	GDSC	CP466722	5.1665
SIDM00374	DLBC\|B_cell_lymphoma	p.H1380Y (No)	GDSC	CP466722	5.4241
SIDM00374	DLBC\|B_cell_lymphoma	p.H1380Y (No)	GDSC	KU-55933	66.6475
SIDM00374	DLBC\|B_cell_lymphoma	p.H1380Y (No)	GDSC	KU-60019	127.9272
SIDM00556	NB\|neuroblastoma	p.H1380Y (No)	GDSC	CP466722	124.1703
SIDM00556	NB\|neuroblastoma	p.H1380Y (No)	GDSC	KU-55933	56.6437
SIDM00556	NB\|neuroblastoma	p.H1380Y (No)	GDSC	KU-60019	53.5025
SIDM00878	BRCA\|breast	p.L1824F (No)	GDSC	CP466722	4.0464
SIDM00878	BRCA\|breast	p.L1824F (No)	GDSC	KU-55933	25.0224
SIDM00878	BRCA\|breast	p.L1824F (No)	GDSC	KU-60019	22.7822
SIDM00878	BRCA\|breast	p.L1824F (No)	GDSC	KU-55933	111.49
SIDM00043	HNSC\|head_and_neck	p.Q2825P (No)	GDSC	CP466722	5.8328
SIDM00043	HNSC\|head_and_neck	p.Q2825P (No)	GDSC	KU-55933	15.2105
SIDM00043	HNSC\|head_and_neck	p.Q2825P (No)	GDSC	KU-60019	8.2147
SIDM00571	UNCLASSIFIED\|pancreas	p.H1380Y (No)	GDSC	CP466722	7.258
SIDM00571	UNCLASSIFIED\|pancreas	p.H1380Y (No)	GDSC	KU-55933	229.2413
SIDM00571	UNCLASSIFIED\|pancreas	p.H1380Y (No)	GDSC	KU-60019	169.3082
SIDM00284	SKCM\|melanoma	p.A1670V (No)	GDSC	CP466722	15.5553
SIDM00284	SKCM\|melanoma	p.A1670V (No)	GDSC	KU-55933	114.9031
SIDM00284	SKCM\|melanoma	p.A1670V (No)	GDSC	KU-60019	12.6192
SIDM00579	NB\|neuroblastoma	p.R451H (No)	GDSC	CP466722	9.7698
SIDM00579	NB\|neuroblastoma	p.R451H (No)	GDSC	KU-55933	29.0691
SIDM00579	NB\|neuroblastoma	p.R451H (No)	GDSC	KU-60019	110.2653
SIDM00796	UNCLASSIFIED\|head_and_neck	p.S49C (No)	GDSC	CP466722	15.1489
SIDM00796	UNCLASSIFIED\|head_and_neck	p.S49C (No)	GDSC	KU-55933	87.7939
SIDM00796	UNCLASSIFIED\|head_and_neck	p.S49C (No)	GDSC	KU-60019	13.3624
SIDM00193	COREAD\|large_intestine	p.L1419I (No)	GDSC	CP466722	4.1034
SIDM00193	COREAD\|large_intestine	p.L1419I (No)	GDSC	KU-55933	25.2727
SIDM00193	COREAD\|large_intestine	p.L1419I (No)	GDSC	KU-60019	15.6242
SIDM00193	COREAD\|large_intestine	p.L1794M (No)	GDSC	CP466722	4.1034
SIDM00193	COREAD\|large_intestine	p.L1794M (No)	GDSC	KU-55933	25.2727
SIDM00193	COREAD\|large_intestine	p.L1794M (No)	GDSC	KU-60019	15.6242
SIDM00118	COREAD\|large_intestine	p.E1133K (No)	GDSC	CP466722	13.3514
SIDM00118	COREAD\|large_intestine	p.E1133K (No)	GDSC	KU-55933	95.2793
SIDM00118	COREAD\|large_intestine	p.E1133K (No)	GDSC	KU-60019	50.0573
SIDM00118	COREAD\|large_intestine	p.L1439I (No)	GDSC	CP466722	13.3514
SIDM00118	COREAD\|large_intestine	p.L1439I (No)	GDSC	KU-55933	95.2793
SIDM00118	COREAD\|large_intestine	p.L1439I (No)	GDSC	KU-60019	50.0573
SIDM00697	SCLC\|lung_small_cell_carcinoma	p.P604S (No)	GDSC	CP466722	45.2927
SIDM00697	SCLC\|lung_small_cell_carcinoma	p.P604S (No)	GDSC	KU-55933	122.2338
SIDM00697	SCLC\|lung_small_cell_carcinoma	p.P604S (No)	GDSC	KU-60019	156.157

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MNLFND

Degron related mutations and impact score

Drug responses associated with ATM mutations

All proteins holding degron of MNLFND

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13315	Serine-protein kinase ATM	LIG_APCC_ABBA_1	855:860	MNLFND	APC,CDC20,FZR1	0.8801	More...