DegronMD

Uniprot ID: Q96BA8

Source protein: Cyclic AMP-responsive element-binding protein 3-like protein 1

Source gene: CREB3L1

Class: DEG_SCF_FBW7_1

Location: 204:211

E3 ligase: FBXW7

DEGRON score: 0.9975

ASA_SCORE: 75.1875

COIL: 0.9511

CONS_SCORE: 0.5775

DSS_SCORE: 0.8072

HELIX: 0.0223

FCONS_SCORE: 1.5889

RIG_SCORE: 0.5269

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P206S	TCGA-D3-A8GM	SKCM	TCGA	MPPTPPSS	DEG_SCF_FBW7_1	0.5641
p.P206S	DO50288	SKCM	ICGC	MPPTPPSS	DEG_SCF_FBW7_1	0.5641
p.V202M	TCGA-AX-A06F	UCEC	TCGA	MPPTPPSS	DEG_SCF_FBW7_1	0.2778
p.V202M	DO41752	UCEC	ICGC	MPPTPPSS	DEG_SCF_FBW7_1	0.2778
p.V202L	DO224634	BRCA	ICGC	MPPTPPSS	DEG_SCF_FBW7_1	0.2778
p.V202L	DO1078	BRCA	ICGC	MPPTPPSS	DEG_SCF_FBW7_1	0.2778
p.D200V	SIDM00662	Melanoma	GDSC	MPPTPPSS	DEG_SCF_FBW7_1	0.2222
p.D200V	SIDM00831	Head and Neck Carcinoma	GDSC	MPPTPPSS	DEG_SCF_FBW7_1	0.2222
p.D200V	SIDM00107	Melanoma	GDSC	MPPTPPSS	DEG_SCF_FBW7_1	0.2222
p.D200V	SIDM01177	B-Lymphoblastic Leukemia	GDSC	MPPTPPSS	DEG_SCF_FBW7_1	0.2222
p.D200V	SIDM00716	Squamous Cell Lung Carcinoma	GDSC	MPPTPPSS	DEG_SCF_FBW7_1	0.2222
p.D200V	SIDM00098	Mesothelioma	GDSC	MPPTPPSS	DEG_SCF_FBW7_1	0.2222
p.D200V	SIDM00964	Non-Cancerous	GDSC	MPPTPPSS	DEG_SCF_FBW7_1	0.2222
p.D200V	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	MPPTPPSS	DEG_SCF_FBW7_1	0.2222
p.D200V	SIDM00674	Non-Cancerous	GDSC	MPPTPPSS	DEG_SCF_FBW7_1	0.2222
p.D200V	SIDM01190	Bladder Carcinoma	GDSC	MPPTPPSS	DEG_SCF_FBW7_1	0.2222
p.D200V	SIDM00675	Breast Carcinoma	GDSC	MPPTPPSS	DEG_SCF_FBW7_1	0.2222
p.G218S	TCGA-F7-A624	HNSC	TCGA	MPPTPPSS	DEG_SCF_FBW7_1	0.1389
p.G218S	DO44440	HNSC	ICGC	MPPTPPSS	DEG_SCF_FBW7_1	0.1389

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96BA8	Cyclic AMP-responsive element-binding protein 3-like protein 1	DEG_SCF_FBW7_1	204:211	MPPTPPSS	FBXW7	0.9975	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons