DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
MPTPLYS
Uniprot ID:
P63119
Source protein:
Endogenous retrovirus group K member 21 Pro protein
Source gene:
ERVK-21
Class:
DEG_SCF_FBW7_1
Location:
106:112
E3 ligase:
FBXW7
DEGRON score:
0.9922
ASA_SCORE:
64.1571
COIL:
0.8754
CONS_SCORE:
0.522
DSS_SCORE:
0.3825
HELIX:
0.0194
FCONS_SCORE:
0.8825
RIG_SCORE:
0.7764
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with ERVK-21 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of MPTPLYS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P63119
Endogenous retrovirus group K member 21 Pro protein
DEG_SCF_FBW7_1
106:112
MPTPLYS
FBXW7
0.9922
More...