DegronMD

Uniprot ID: Q8N7H5

Source protein: RNA polymerase II-associated factor 1 homolog

Source gene: PAF1

Class: LIG_APCC_ABBA_1

Location: 205:210

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7257

ASA_SCORE: 31.4333

COIL: 0.5858

CONS_SCORE: 0.7065

DSS_SCORE: 0.1913

HELIX: 0.0387

FCONS_SCORE: 1.2515

RIG_SCORE: 0.8594

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P201L	TCGA-D1-A17H	UCEC	TCGA	MPVFPD	LIG_APCC_ABBA_1	0.2222
p.P201L	DO41847	UCEC	ICGC	MPVFPD	LIG_APCC_ABBA_1	0.2222
p.A219V	TCGA-FI-A2D5	UCEC	TCGA	MPVFPD	LIG_APCC_ABBA_1	0.0833
p.A219V	DO41331	UCEC	ICGC	MPVFPD	LIG_APCC_ABBA_1	0.0833
p.F211L	TCGA-FR-A726	SKCM	TCGA	MPVFPD	LIG_APCC_ABBA_1	0.3056
p.F211L	DO48665	SKCM	ICGC	MPVFPD	LIG_APCC_ABBA_1	0.3056
p.E203D	TCGA-G4-6297	COAD	TCGA	MPVFPD	LIG_APCC_ABBA_1	0.2778
p.E203D	DO9418	COAD	ICGC	MPVFPD	LIG_APCC_ABBA_1	0.2778
p.R198Q	DO229342	BTCA	ICGC	MPVFPD	LIG_APCC_ABBA_1	0.1389
p.V199G	DO232224	PBCA	ICGC	MPVFPD	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N7H5	RNA polymerase II-associated factor 1 homolog	LIG_APCC_ABBA_1	205:210	MPVFPD	APC,CDC20,FZR1	0.7257	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons