DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
MQGTPDDE
Uniprot ID:
Q96GY3
Source protein:
Protein lin-37 homolog
Source gene:
LIN37
Class:
DEG_SCF_FBW7_2
Location:
188:195
E3 ligase:
FBXW7
DEGRON score:
0.6959
ASA_SCORE:
86.25
COIL:
0.8953
CONS_SCORE:
0.3539
DSS_SCORE:
0.9064
HELIX:
0.066
FCONS_SCORE:
0.7554
RIG_SCORE:
0.5279
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E200K
TCGA-44-8119
LUAD
TCGA
MQGTPDDE
DEG_SCF_FBW7_2
0.1944
p.E200K
DO24399
LUAD
ICGC
MQGTPDDE
DEG_SCF_FBW7_2
0.1944
p.R179H
TCGA-BR-8680
STAD
TCGA
MQGTPDDE
DEG_SCF_FBW7_2
0.0833
p.R179H
DO47769
STAD
ICGC
MQGTPDDE
DEG_SCF_FBW7_2
0.0833
p.P183S
TCGA-CR-6473
HNSC
TCGA
MQGTPDDE
DEG_SCF_FBW7_2
0.1944
p.P183S
DO14228
HNSC
ICGC
MQGTPDDE
DEG_SCF_FBW7_2
0.1944
p.P196S
TCGA-D3-A8GB
SKCM
TCGA
MQGTPDDE
DEG_SCF_FBW7_2
0.3056
p.P196S
DO50280
SKCM
ICGC
MQGTPDDE
DEG_SCF_FBW7_2
0.3056
p.P183Q
TCGA-DA-A1I1
SKCM
TCGA
MQGTPDDE
DEG_SCF_FBW7_2
0.1944
p.P183Q
DO37966
SKCM
ICGC
MQGTPDDE
DEG_SCF_FBW7_2
0.1944
p.D194N
TCGA-EO-A22U
UCEC
TCGA
MQGTPDDE
DEG_SCF_FBW7_2
0.5821
p.D194N
DO43755
UCEC
ICGC
MQGTPDDE
DEG_SCF_FBW7_2
0.5821
p.D194N
SIDM00630
Breast Carcinoma
GDSC
MQGTPDDE
DEG_SCF_FBW7_2
0.5821
p.D194N
MDA-MB-415
breast
COSMIC
MQGTPDDE
DEG_SCF_FBW7_2
0.5821
p.G190C
TCGA-FS-A1Z4
SKCM
TCGA
MQGTPDDE
DEG_SCF_FBW7_2
0.6489
p.G190C
DO37462
SKCM
ICGC
MQGTPDDE
DEG_SCF_FBW7_2
0.6489
p.E187D
TCGA-OL-A5RZ
BRCA
TCGA
MQGTPDDE
DEG_SCF_FBW7_2
0.3056
p.E187D
DO44228
BRCA
ICGC
MQGTPDDE
DEG_SCF_FBW7_2
0.3056
p.M188I
TCGA-VS-A9UJ
CESC
TCGA
MQGTPDDE
DEG_SCF_FBW7_2
0.6507
p.M188I
DO219735
CESC
ICGC
MQGTPDDE
DEG_SCF_FBW7_2
0.6507
p.S197C
DO218173
BRCA
ICGC
MQGTPDDE
DEG_SCF_FBW7_2
0.2778
p.P181S
SIDM00551
Esophageal Squamous Cell Carcinoma
GDSC
MQGTPDDE
DEG_SCF_FBW7_2
0.1389
p.P181S
KYSE-220
oesophagus
COSMIC
MQGTPDDE
DEG_SCF_FBW7_2
0.1389
p.E200A
SIDM00278
Esophageal Squamous Cell Carcinoma
GDSC
MQGTPDDE
DEG_SCF_FBW7_2
0.1944
p.E200A
ACH-000305
Esophageal Cancer
CCLE
MQGTPDDE
DEG_SCF_FBW7_2
0.1944
p.E200A
EC-GI-10
oesophagus
COSMIC
MQGTPDDE
DEG_SCF_FBW7_2
0.1944
Drug responses associated with LIN37 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of MQGTPDDE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96GY3
Protein lin-37 homolog
DEG_SCF_FBW7_2
188:195
MQGTPDDE
FBXW7
0.6959
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