DegronMD

Uniprot ID: Q96GY3

Source protein: Protein lin-37 homolog

Source gene: LIN37

Class: DEG_SCF_FBW7_2

Location: 188:195

E3 ligase: FBXW7

DEGRON score: 0.6959

ASA_SCORE: 86.25

COIL: 0.8953

CONS_SCORE: 0.3539

DSS_SCORE: 0.9064

HELIX: 0.066

FCONS_SCORE: 0.7554

RIG_SCORE: 0.5279

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M188I	TCGA-VS-A9UJ	CESC	TCGA	MQGTPDDE	DEG_SCF_FBW7_2	0.6507
p.M188I	DO219735	CESC	ICGC	MQGTPDDE	DEG_SCF_FBW7_2	0.6507
p.G190C	TCGA-FS-A1Z4	SKCM	TCGA	MQGTPDDE	DEG_SCF_FBW7_2	0.6489
p.G190C	DO37462	SKCM	ICGC	MQGTPDDE	DEG_SCF_FBW7_2	0.6489
p.D194N	TCGA-EO-A22U	UCEC	TCGA	MQGTPDDE	DEG_SCF_FBW7_2	0.5821
p.D194N	DO43755	UCEC	ICGC	MQGTPDDE	DEG_SCF_FBW7_2	0.5821
p.D194N	SIDM00630	Breast Carcinoma	GDSC	MQGTPDDE	DEG_SCF_FBW7_2	0.5821
p.D194N	MDA-MB-415	breast	COSMIC	MQGTPDDE	DEG_SCF_FBW7_2	0.5821
p.P196S	TCGA-D3-A8GB	SKCM	TCGA	MQGTPDDE	DEG_SCF_FBW7_2	0.3056
p.P196S	DO50280	SKCM	ICGC	MQGTPDDE	DEG_SCF_FBW7_2	0.3056
p.E187D	TCGA-OL-A5RZ	BRCA	TCGA	MQGTPDDE	DEG_SCF_FBW7_2	0.3056
p.E187D	DO44228	BRCA	ICGC	MQGTPDDE	DEG_SCF_FBW7_2	0.3056
p.S197C	DO218173	BRCA	ICGC	MQGTPDDE	DEG_SCF_FBW7_2	0.2778
p.E200K	TCGA-44-8119	LUAD	TCGA	MQGTPDDE	DEG_SCF_FBW7_2	0.1944
p.E200K	DO24399	LUAD	ICGC	MQGTPDDE	DEG_SCF_FBW7_2	0.1944
p.P183S	TCGA-CR-6473	HNSC	TCGA	MQGTPDDE	DEG_SCF_FBW7_2	0.1944
p.P183S	DO14228	HNSC	ICGC	MQGTPDDE	DEG_SCF_FBW7_2	0.1944
p.P183Q	TCGA-DA-A1I1	SKCM	TCGA	MQGTPDDE	DEG_SCF_FBW7_2	0.1944
p.P183Q	DO37966	SKCM	ICGC	MQGTPDDE	DEG_SCF_FBW7_2	0.1944
p.E200A	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	MQGTPDDE	DEG_SCF_FBW7_2	0.1944
p.E200A	ACH-000305	Esophageal Cancer	CCLE	MQGTPDDE	DEG_SCF_FBW7_2	0.1944
p.E200A	EC-GI-10	oesophagus	COSMIC	MQGTPDDE	DEG_SCF_FBW7_2	0.1944
p.P181S	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	MQGTPDDE	DEG_SCF_FBW7_2	0.1389
p.P181S	KYSE-220	oesophagus	COSMIC	MQGTPDDE	DEG_SCF_FBW7_2	0.1389
p.R179H	TCGA-BR-8680	STAD	TCGA	MQGTPDDE	DEG_SCF_FBW7_2	0.0833

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Drug responses associated with LIN37 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of MQGTPDDE

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96GY3	Protein lin-37 homolog	DEG_SCF_FBW7_2	188:195	MQGTPDDE	FBXW7	0.6959	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MQGTPDDE

Degron related mutations and impact score

Drug responses associated with LIN37 mutations

All proteins holding degron of MQGTPDDE