DegronMD

Uniprot ID: O60938

Source protein: Keratocan

Source gene: KERA

Class: LIG_APCC_ABBA_1

Location: 216:221

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5848

ASA_SCORE: 50.5167

COIL: 0.4617

CONS_SCORE: 0.8893

DSS_SCORE: 0.2731

HELIX: 0.0193

FCONS_SCORE: 1.0374

RIG_SCORE: 0.8297

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R210G	TCGA-05-5425	LUAD	TCGA	MQLFLD	LIG_APCC_ABBA_1	0.1667
p.R210G	DO26270	LUAD	ICGC	MQLFLD	LIG_APCC_ABBA_1	0.1667
p.S224F	TCGA-06-5416	GBM	TCGA	MQLFLD	LIG_APCC_ABBA_1	0.25
p.S224F	TCGA-EO-A22U	UCEC	TCGA	MQLFLD	LIG_APCC_ABBA_1	0.25
p.S224F	DO10880	GBM	ICGC	MQLFLD	LIG_APCC_ABBA_1	0.25
p.S224F	DO43755	UCEC	ICGC	MQLFLD	LIG_APCC_ABBA_1	0.25
p.S224F	SIDM01240	Melanoma	GDSC	MQLFLD	LIG_APCC_ABBA_1	0.25
p.S224F	ACH-001002	Skin Cancer	CCLE	MQLFLD	LIG_APCC_ABBA_1	0.25
p.S224F	451Lu	skin	COSMIC	MQLFLD	LIG_APCC_ABBA_1	0.25
p.N206K	TCGA-43-2576	LUSC	TCGA	MQLFLD	LIG_APCC_ABBA_1	0.0556
p.N206K	DO27005	LUSC	ICGC	MQLFLD	LIG_APCC_ABBA_1	0.0556
p.G227E	TCGA-4Z-AA7N	BLCA	TCGA	MQLFLD	LIG_APCC_ABBA_1	0.1667
p.G227E	DO218978	BLCA	ICGC	MQLFLD	LIG_APCC_ABBA_1	0.1667
p.N206D	TCGA-AA-3715	COAD	TCGA	MQLFLD	LIG_APCC_ABBA_1	0.0556
p.N206D	DO8018	COAD	ICGC	MQLFLD	LIG_APCC_ABBA_1	0.0556
p.R210S	TCGA-AR-A24Q	BRCA	TCGA	MQLFLD	LIG_APCC_ABBA_1	0.1667
p.R210S	DO3524	BRCA	ICGC	MQLFLD	LIG_APCC_ABBA_1	0.1667
p.N206I	TCGA-EE-A2MJ	SKCM	TCGA	MQLFLD	LIG_APCC_ABBA_1	0.0556
p.N206I	DO38099	SKCM	ICGC	MQLFLD	LIG_APCC_ABBA_1	0.0556
p.N222S	TCGA-EO-A22X	UCEC	TCGA	MQLFLD	LIG_APCC_ABBA_1	0.3056
p.N222S	DO43907	UCEC	ICGC	MQLFLD	LIG_APCC_ABBA_1	0.3056
p.Q217P	DO231127	LUSC	ICGC	MQLFLD	LIG_APCC_ABBA_1	0.5924
p.P209L	DO222880	MELA	ICGC	MQLFLD	LIG_APCC_ABBA_1	0.1389
p.A213S	SIDM00728	Non-Small Cell Lung Carcinoma	GDSC	MQLFLD	LIG_APCC_ABBA_1	0.25
p.A213S	ACH-000718	Lung Cancer	CCLE	MQLFLD	LIG_APCC_ABBA_1	0.25
p.A213S	NCI-H2291	lung	COSMIC	MQLFLD	LIG_APCC_ABBA_1	0.25
p.A213V	SIDM00889	Cervical Carcinoma	GDSC	MQLFLD	LIG_APCC_ABBA_1	0.25
p.A213V	C-33-A	cervix	COSMIC	MQLFLD	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60938	Keratocan	LIG_APCC_ABBA_1	216:221	MQLFLD	APC,CDC20,FZR1	0.5848	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MQLFLD

Degron related mutations and impact score

Drug responses associated with KERA mutations

All proteins holding degron of MQLFLD