DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
MRLLLLLLV
Uniprot ID:
P62341
Source protein:
Thioredoxin reductase-like selenoprotein T
Source gene:
SELENOT
Class:
DEG_APCC_DBOX_1
Location:
1:9
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.5779
ASA_SCORE:
88.7222
COIL:
0.1934
CONS_SCORE:
0.2719
DSS_SCORE:
0.18
HELIX:
0.7863
FCONS_SCORE:
1.1656
RIG_SCORE:
0.9589
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A11S
SIDM00541
Colorectal Carcinoma
GDSC
MRLLLLLLV
DEG_APCC_DBOX_1
0.2778
p.A11S
HT55
large_intestine
COSMIC
MRLLLLLLV
DEG_APCC_DBOX_1
0.2778
Drug responses associated with SELENOT mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of MRLLLLLLV
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P62341
Thioredoxin reductase-like selenoprotein T
DEG_APCC_DBOX_1
1:9
MRLLLLLLV
APC,CDC20,FZR1
0.5779
More...