DegronMD

Uniprot ID: Q9UIG0

Source protein: Tyrosine-protein kinase BAZ1B

Source gene: BAZ1B

Class: DEG_SCF_FBW7_1

Location: 898:905

E3 ligase: FBXW7

DEGRON score: 0.5823

ASA_SCORE: 57.0125

COIL: 0.547

CONS_SCORE: 0.5283

DSS_SCORE: 0.3299

HELIX: 0.056

FCONS_SCORE: 1.0749

RIG_SCORE: 0.7697

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R899H	TCGA-61-2101	OV	TCGA	MRRTPIGT	DEG_SCF_FBW7_1	0.7133
p.R899H	DO28062	OV	ICGC	MRRTPIGT	DEG_SCF_FBW7_1	0.7133
p.F915L	TCGA-AP-A1DV	UCEC	TCGA	MRRTPIGT	DEG_SCF_FBW7_1	0.0556
p.F915L	DO43186	UCEC	ICGC	MRRTPIGT	DEG_SCF_FBW7_1	0.0556
p.R899C	TCGA-AX-A1CE	UCEC	TCGA	MRRTPIGT	DEG_SCF_FBW7_1	0.719
p.R899C	DO42280	UCEC	ICGC	MRRTPIGT	DEG_SCF_FBW7_1	0.719
p.A892V	TCGA-C5-A7UH	CESC	TCGA	MRRTPIGT	DEG_SCF_FBW7_1	0.1667
p.A892V	DO49891	CESC	ICGC	MRRTPIGT	DEG_SCF_FBW7_1	0.1667
p.L914F	DO225311	BRCA	ICGC	MRRTPIGT	DEG_SCF_FBW7_1	0.0833
p.M898V	SIDM00878	Breast Carcinoma	GDSC	MRRTPIGT	DEG_SCF_FBW7_1	0.6097
p.M898V	ACH-000930	Breast Cancer	CCLE	MRRTPIGT	DEG_SCF_FBW7_1	0.6097
p.M898V	HCC1569	breast	COSMIC	MRRTPIGT	DEG_SCF_FBW7_1	0.6097

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UIG0	Tyrosine-protein kinase BAZ1B	DEG_SCF_FBW7_1	898:905	MRRTPIGT	FBXW7	0.5823	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons